ENKUR and LRRK1

Number of citations: 77 (PubMedID 29513927)
Data Source: BioGRID (pull down)

		ENKUR	LRRK1
Name		enkurin, TRPC channel interacting protein	leucine rich repeat kinase 1
Structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Sperm Principal Piece 9+0 Motile Cilium 9+2 Motile Cilium Axonemal B Tubule Inner Sheath	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Calmodulin Binding SH3 Domain Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Flagellated Sperm Motility Establishment Of Left/right Asymmetry	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
GWAS		No GWAS studies recorded	Central corneal thickness ( 28171582 29760442 31798171 32528159 ) Corneal structure ( 23291589 ) Height ( 28552196 ) Systemic lupus erythematosus ( 33272962 )
Novel Interactors		1 novel interactors: GPR158	2 novel interactors: SELENOS TM2D3
Interacting Genes		6 interacting genes: CFAP45 LRRK1 LRRK2 PIK3R1 PIK3R2 TRPC5	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4
Entrez ID		219670	79705
HPRD ID		12583	14319
Ensembl ID		ENSG00000151023	ENSG00000154237
Uniprot IDs		A0A087WUX1 Q8TC29	Q38SD2
PDB IDs		7UNG 8J07	8E04 8E05 8E06 8FAC
GO Terms Enriched among Interactors		Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding Intracellular Chemical Homeostasis Homeostatic Process Cellular Homeostasis Clathrin Binding GTPase Activator Activity Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Phosphotyrosine Residue Binding Positive Regulation Of Transport Chemical Homeostasis Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Insulin Stimulus Regulation Of Stress Fiber Assembly Positive Regulation Of Intracellular Protein Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Localization To Nucleus Insulin Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion G Protein-coupled Glycine Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cellular Localization B Cell Differentiation Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Regulation Of Protein Localization To Plasma Membrane Regulation Of Nucleocytoplasmic Transport Kinase Regulator Activity Import Into Nucleus Perinuclear Endoplasmic Reticulum Membrane Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Protein Autoubiquitination	Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy