ENKUR and CFAP45

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ENKUR	CFAP45
Description		enkurin, TRPC channel interacting protein	cilia and flagella associated protein 45
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Sperm Principal Piece 9+0 Motile Cilium 9+2 Motile Cilium Axonemal B Tubule Inner Sheath	Extracellular Region Nucleus Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection 9+0 Motile Cilium 9+2 Motile Cilium Polymeric Cytoskeletal Fiber Axonemal B Tubule Inner Sheath
	Molecular Function	Protein Binding Calmodulin Binding SH3 Domain Binding	Protein Binding AMP Binding
	Biological Process	Flagellated Sperm Motility Establishment Of Left/right Asymmetry	Flagellated Sperm Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Establishment Of Left/right Asymmetry Cerebrospinal Fluid Circulation
Pathways
Drugs
Diseases
GWAS
Interacting Genes		6 interacting genes: CFAP45 LRRK1 LRRK2 PIK3R1 PIK3R2 TRPC5	1 interacting genes: ENKUR
Entrez ID		219670	25790
HPRD ID		12583	05514
Ensembl ID		ENSG00000151023	ENSG00000213085
Uniprot IDs		A0A087WUX1 Q8TC29	Q9UL16
PDB IDs		7UNG 8J07	7UNG 8J07
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding Intracellular Chemical Homeostasis Homeostatic Process Cellular Homeostasis Clathrin Binding GTPase Activator Activity Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Phosphotyrosine Residue Binding Positive Regulation Of Transport Chemical Homeostasis Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Insulin Stimulus Regulation Of Stress Fiber Assembly Positive Regulation Of Intracellular Protein Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Localization To Nucleus Insulin Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion G Protein-coupled Glycine Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cellular Localization B Cell Differentiation Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Regulation Of Protein Localization To Plasma Membrane Regulation Of Nucleocytoplasmic Transport Kinase Regulator Activity Import Into Nucleus Perinuclear Endoplasmic Reticulum Membrane Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Protein Autoubiquitination	Establishment Of Left/right Asymmetry Axonemal B Tubule Inner Sheath 9+0 Motile Cilium 9+2 Motile Cilium Axonemal Microtubule Sperm Principal Piece Sperm Flagellum Determination Of Bilateral Symmetry Sperm Motility Flagellated Sperm Motility Acrosomal Vesicle Cilium Movement Involved In Cell Motility SH3 Domain Binding Determination Of Left/right Symmetry Cilium-dependent Cell Motility Cilium Movement Calmodulin Binding Motile Cilium Microtubule Cytoskeleton Pattern Specification Process Microtubule-based Movement Cilium
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