ENKUR and PIK3R2

Number of citations of the paper that reports this interaction (PubMedID 15385169)
0

Data Source:
BioGRID (pull down)

		ENKUR	PIK3R2
Description		enkurin, TRPC channel interacting protein	phosphoinositide-3-kinase regulatory subunit 2
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Sperm Flagellum Cell Projection Sperm Principal Piece 9+0 Motile Cilium 9+2 Motile Cilium Axonemal B Tubule Inner Sheath	Nucleus Cytosol Focal Adhesion Phosphatidylinositol 3-kinase Complex, Class IA
	Molecular Function	Protein Binding Calmodulin Binding SH3 Domain Binding	Phosphotyrosine Residue Binding GTPase Activator Activity Protein Binding Protein Phosphatase Binding Receptor Tyrosine Kinase Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding 1-phosphatidylinositol-3-kinase Regulator Activity Protein Heterodimerization Activity
	Biological Process	Flagellated Sperm Motility Establishment Of Left/right Asymmetry	Intracellular Glucose Homeostasis Immune Response Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Autophagy Protein Transport B Cell Differentiation T Cell Differentiation Regulation Of Actin Filament Polymerization Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of MAPK Cascade Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Stress Fiber Assembly Regulation Of Protein Localization To Plasma Membrane
Pathways			PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Signaling by ALK Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions CD28 dependent PI3K/Akt signaling G alpha (q) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle Signaling by ALK fusions and activated point mutants Signaling by LTK in cancer Signaling by LTK High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Co-stimulation by ICOS
Drugs			SF1126
Diseases
GWAS			Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Mental health study participation (completed survey) ( 31263887)
Interacting Genes		6 interacting genes: CFAP45 LRRK1 LRRK2 PIK3R1 PIK3R2 TRPC5	60 interacting genes: APP APPL1 AR ARRB1 AXL CBL CD28 CRK CRKL CSF1R DYDC1 EGF EGFR ENKUR EPHA2 ERBB2 ERBB3 ERBB4 FBXL2 FGFR1 FYN GAB1 GHR GOLGA2 GRB2 GRN HCK IGF1R IKZF3 IRS1 IRS2 KIT KRAS KRT15 KRT20 KRT38 LAMB2 LMNA LTBP3 MET MRFAP1L1 PDGFRB PIK3CB PIK3CD RINT1 SEPTIN2 SHC1 SOCS1 SOCS6 SOCS7 SOS1 STAB1 STAT3 SYK TEC TGFBR1 TGFBR2 TRIM23 WASF3 YWHAB
Entrez ID		219670	5296
HPRD ID		12583	04404
Ensembl ID		ENSG00000151023	ENSG00000105647
Uniprot IDs		A0A087WUX1 Q8TC29	O00459
PDB IDs		7UNG 8J07	2KT1 2XS6 3MTT 3O5Z 6OX7 6U28 7RCH 7RNU
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Regulatory Subunit Binding Intracellular Chemical Homeostasis Homeostatic Process Cellular Homeostasis Clathrin Binding GTPase Activator Activity Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Phosphotyrosine Residue Binding Positive Regulation Of Transport Chemical Homeostasis Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Insulin Stimulus Regulation Of Stress Fiber Assembly Positive Regulation Of Intracellular Protein Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Localization To Nucleus Insulin Receptor Signaling Pathway Regulation Of Neurotransmitter Secretion G Protein-coupled Glycine Receptor Activity Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Curcumin Caveola Neck Negative Regulation Of Late Endosome To Lysosome Transport Amphisome Peroxidase Inhibitor Activity Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion GTP-dependent Protein Kinase Activity Beta-catenin Destruction Complex Binding Wnt Signalosome Assembly Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Cellular Localization B Cell Differentiation Regulation Of Establishment Of Protein Localization Regulation Of Cellular Component Organization Protein Import Into Nucleus Regulation Of Protein Localization To Plasma Membrane Regulation Of Nucleocytoplasmic Transport Kinase Regulator Activity Import Into Nucleus Perinuclear Endoplasmic Reticulum Membrane Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Protein Autoubiquitination	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Tyrosine Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Receptor Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of Cell Population Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Cell Migration Regulation Of Cell Population Proliferation Regulation Of Developmental Process Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Locomotion Kinase Activity Positive Regulation Of MAPK Cascade Protein Kinase Activity Developmental Process Peptidyl-tyrosine Phosphorylation Response To Growth Factor Positive Regulation Of Multicellular Organismal Process Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Cellular Response To Growth Factor Stimulus Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Development Cell Population Proliferation Growth Factor Binding Positive Regulation Of Epithelial Cell Proliferation Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Morphogenesis Of An Epithelium ERBB Signaling Pathway Tissue Morphogenesis
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