MEOX2 and TGFB1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MEOX2	TGFB1
Gene Name		mesenchyme homeobox 2	transforming growth factor, beta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Axon Platelet Alpha Granule Lumen Neuronal Cell Body Blood Microparticle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Glycoprotein Binding Antigen Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Angiogenesis Somite Specification Transcription, DNA-templated Multicellular Organismal Development Skeletal Muscle Tissue Development Blood Circulation Positive Regulation Of Transcription From RNA Polymerase II Promoter Palate Development Limb Development Neuron Death	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Ureteric Bud Development Response To Hypoxia Epithelial To Mesenchymal Transition Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Sodium Ion Transport Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Tolerance Induction To Self Antigen Platelet Degranulation Protein Phosphorylation Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly SMAD Protein Import Into Nucleus Negative Regulation Of Neuroblast Proliferation Salivary Gland Morphogenesis Endoderm Development Female Pregnancy Aging Blood Coagulation Negative Regulation Of DNA Replication Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Germ Cell Migration Response To Radiation Response To Wounding Response To Glucose Defense Response To Fungus, Incompatible Interaction Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Cell Growth Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Modulation By Virus Of Host Morphology Or Physiology Evasion Or Tolerance Of Host Defenses By Virus Viral Life Cycle Negative Regulation Of Cell-cell Adhesion Platelet Activation Extracellular Matrix Organization Hyaluronan Catabolic Process Negative Regulation Of Ossification Negative Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Histone Deacetylation Organ Regeneration Positive Regulation Of Protein Complex Assembly Positive Regulation Of Exit From Mitosis Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Response To Progesterone Positive Regulation Of Interleukin-17 Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Mononuclear Cell Proliferation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Response To Vitamin D Response To Laminar Fluid Shear Stress Positive Regulation Of Histone Acetylation Positive Regulation Of Protein Dephosphorylation Negative Regulation Of T Cell Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Odontogenesis Response To Drug Myelination Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation T Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Ossification Involved In Bone Remodeling Regulatory T Cell Differentiation Cell-cell Junction Organization Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Active Induction Of Host Immune Response By Virus Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Digestive Tract Development Negative Regulation Of Skeletal Muscle Tissue Development Inner Ear Development Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Negative Regulation Of Phagocytosis Positive Regulation Of Chemotaxis Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Binding Regulation Of DNA Binding Positive Regulation Of Smooth Muscle Cell Differentiation Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Blood Vessel Remodeling Face Morphogenesis Frontal Suture Morphogenesis Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of SMAD Protein Import Into Nucleus SMAD Protein Signal Transduction Mammary Gland Branching Involved In Thelarche Branch Elongation Involved In Mammary Gland Duct Branching Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cartilage Development Lens Fiber Cell Differentiation Response To Cholesterol Positive Regulation Of Cell Cycle Arrest Cellular Response To Organic Cyclic Compound Cellular Response To Dexamethasone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Extracellular Matrix Assembly Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Actin Cytoskeleton Reorganization Regulation Of MiRNA Metabolic Process Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Loss of Function of TGFBR2 in Cancer Elastic fibre formation Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Platelet degranulation TGF-beta receptor signaling activates SMADs Host Interactions with Influenza Factors TGFBR1 LBD Mutants in Cancer Influenza Virus Induced Apoptosis Molecules associated with elastic fibres ECM proteoglycans Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Non-integrin membrane-ECM interactions Influenza Infection Loss of Function of TGFBR1 in Cancer Syndecan interactions Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Platelet activation, signaling and aggregation SMAD4 MH2 Domain Mutants in Cancer
Drugs			Hyaluronidase
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		207 interactors: ADAMTS12 AGPAT1 AHCYL1 AHSA2 ANP32B ARHGEF7 ARNT2 ATG5 ATXN1L BCL2L15 C19orf66 C1orf109 CARD9 CASP14 CCDC103 CCNC CDH9 CEP57L1 CHIC2 CHRD CIAPIN1 CIB3 CNTNAP2 COX1 CPNE6 CPSF4 CRCT1 CSDC2 CSF2 CTNNBL1 CXXC1 DGCR6 DGCR8 DOCK8 DYNLL2 EDF1 EFEMP2 EFNA3 EIF1AD EIF5A EPM2AIP1 ESR2 ESRRG FAM13C FAM3A FAM74A4 FBF1 FOXR1 FUCA2 FUT11 GABRB3 GAGE1 GLO1 GMCL1P1 GMPR2 GNG11 GOLGA8DP GOLGA8EP GOLGA8F GPATCH2L GPSM3 HAT1 HDHD2 HEXIM2 HGF HLA-A HNRNPD HP1BP3 HSPA2 HTR1E IGF2BP3 IGFN1 INPP1 IP6K2 ITM2A KAT5 KIZ KLC4 KLHL38 KRT80 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KTN1 LAMTOR5 LCE1B LCE2A LCE4A LOC153684 LSM2 MAGED1 MAPKBP1 MKRN3 MLLT6 MMP3 MORN3 MRFAP1L1 MSI2 MT1DP MTMR10 MUM1 MVP MYBPC1 NAA10 NALCN NCALD NCK2 ND1 NLGN3 NTF3 OIT3 OSGIN1 P4HA3 PACSIN2 PAGE2 PARK2 PARVG PAX1 PAX3 PCDH9 PCSK5 PGBD1 PIN1 PKIG POM121C PRKAB2 PRR19 PSMB10 PSMC1 PSMD14 PTGER3 RARB RCHY1 RECK RHOJ RMND5A RND2 RPL15 RUNX1T1 SAMM50 SCNM1 SEPP1 SET SIRPB1 SLC48A1 SMAD3 SMARCE1 SPATA1 SPP1 SPRY1 SPRY2 SSX3 STK16 STX11 STX16 SYT17 TBCEL TBX6 TCEA2 TCL6 TCTEX1D1 TDO2 TGFB1 TICAM2 TMEM100 TP53BP1 TRAF6 TRIM41 TRIM42 TTC25 TTC39B TTC9C TULP2 TXLNA UBE3A UBL4A UBL4B UNC45A USE1 VEZF1 VIP WFDC9 XRCC2 ZBED4 ZMAT2 ZNF124 ZNF329 ZNF404 ZNF417 ZNF483 ZNF564 ZNF572 ZNF587 ZNF695	39 interactors: ACVRL1 APP BGN BMP2 BMP3 CCDC33 CCL3 COL2A1 CTGF DAXX DCN DPT EIF3I ENG FCN1 FKBP1A FMOD FNTA ITGAV ITGB6 ITGB8 LAMB1 LTBP1 LTBP3 LTBP4 MEOX2 MMP2 MMP9 PZP SDC2 SPARC TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 VASN VTN YWHAE
Entrez ID		4223	7040
HPRD ID		02760	01821
Ensembl ID		ENSG00000106511
Uniprot IDs		P50222	P01137
PDB IDs			1KLA 1KLC 1KLD 3KFD
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Death Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Epithelium Development Positive Regulation Of Gene Expression Developmental Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Cell Death Regulation Of RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Death Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of DNA Binding RNA Metabolic Process System Development Regulation Of Protein Ubiquitination Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Binding Myeloid Dendritic Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Ubiquitination Myeloid Dendritic Cell Activation	Extracellular Matrix Organization Extracellular Structure Organization Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cell Surface Receptor Signaling Pathway Skeletal System Development Cardiovascular System Development Tissue Development Regulation Of Locomotion Multicellular Organismal Development Regulation Of Cellular Component Movement Anatomical Structure Formation Involved In Morphogenesis Locomotion Regulation Of Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Anatomical Structure Morphogenesis Cellular Response To Organic Substance Regulation Of Cell Motility Regulation Of Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Blood Vessel Development Response To Organic Substance Vasculature Development Response To Stimulus Response To Abiotic Stimulus Organ Development Developmental Process System Development Cellular Response To Stimulus Angiogenesis Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Metabolic Process Signal Transduction Positive Regulation Of Locomotion Organ Morphogenesis Anatomical Structure Development Movement Of Cell Or Subcellular Component Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Wounding
Tagcloud ?		activates angiogenic biphasic colocalization colocalizes constructs depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate modulates normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		activates angiogenic biphasic colocalization colocalizes constructs depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate modulates normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?