MEOX2 and HSPA2

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MEOX2	HSPA2
Gene Name		mesenchyme homeobox 2	heat shock 70kDa protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Nuclear Speck	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Mitochondrion Cytosol Cell Surface Membrane CatSper Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Protein Binding ATP Binding Enzyme Binding Unfolded Protein Binding Glycolipid Binding
	Biological Process	Angiogenesis Somite Specification Transcription, DNA-templated Multicellular Organismal Development Skeletal Muscle Tissue Development Blood Circulation Positive Regulation Of Transcription From RNA Polymerase II Promoter Palate Development Limb Development Neuron Death	Response To Unfolded Protein Male Meiosis Male Meiosis I Spermatid Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Protein Refolding Synaptonemal Complex Disassembly Negative Regulation Of Inclusion Body Assembly
Pathways			HSF1-dependent transactivation Attenuation phase Meiotic synapsis Cellular response to heat stress Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Blood trace element (Zn levels) ( 23720494)
Protein-Protein Interactions		207 interactors: ADAMTS12 AGPAT1 AHCYL1 AHSA2 ANP32B ARHGEF7 ARNT2 ATG5 ATXN1L BCL2L15 C19orf66 C1orf109 CARD9 CASP14 CCDC103 CCNC CDH9 CEP57L1 CHIC2 CHRD CIAPIN1 CIB3 CNTNAP2 COX1 CPNE6 CPSF4 CRCT1 CSDC2 CSF2 CTNNBL1 CXXC1 DGCR6 DGCR8 DOCK8 DYNLL2 EDF1 EFEMP2 EFNA3 EIF1AD EIF5A EPM2AIP1 ESR2 ESRRG FAM13C FAM3A FAM74A4 FBF1 FOXR1 FUCA2 FUT11 GABRB3 GAGE1 GLO1 GMCL1P1 GMPR2 GNG11 GOLGA8DP GOLGA8EP GOLGA8F GPATCH2L GPSM3 HAT1 HDHD2 HEXIM2 HGF HLA-A HNRNPD HP1BP3 HSPA2 HTR1E IGF2BP3 IGFN1 INPP1 IP6K2 ITM2A KAT5 KIZ KLC4 KLHL38 KRT80 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KTN1 LAMTOR5 LCE1B LCE2A LCE4A LOC153684 LSM2 MAGED1 MAPKBP1 MKRN3 MLLT6 MMP3 MORN3 MRFAP1L1 MSI2 MT1DP MTMR10 MUM1 MVP MYBPC1 NAA10 NALCN NCALD NCK2 ND1 NLGN3 NTF3 OIT3 OSGIN1 P4HA3 PACSIN2 PAGE2 PARK2 PARVG PAX1 PAX3 PCDH9 PCSK5 PGBD1 PIN1 PKIG POM121C PRKAB2 PRR19 PSMB10 PSMC1 PSMD14 PTGER3 RARB RCHY1 RECK RHOJ RMND5A RND2 RPL15 RUNX1T1 SAMM50 SCNM1 SEPP1 SET SIRPB1 SLC48A1 SMAD3 SMARCE1 SPATA1 SPP1 SPRY1 SPRY2 SSX3 STK16 STX11 STX16 SYT17 TBCEL TBX6 TCEA2 TCL6 TCTEX1D1 TDO2 TGFB1 TICAM2 TMEM100 TP53BP1 TRAF6 TRIM41 TRIM42 TTC25 TTC39B TTC9C TULP2 TXLNA UBE3A UBL4A UBL4B UNC45A USE1 VEZF1 VIP WFDC9 XRCC2 ZBED4 ZMAT2 ZNF124 ZNF329 ZNF404 ZNF417 ZNF483 ZNF564 ZNF572 ZNF587 ZNF695	9 interactors: APP CDK1 EWSR1 HSPBP1 MAP3K3 MEOX2 PARP1 SAE1 TRIM38
Entrez ID		4223	3306
HPRD ID		02760	07174
Ensembl ID		ENSG00000106511	ENSG00000126803
Uniprot IDs		P50222	P54652
PDB IDs			3I33 4FSV
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Death Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Epithelium Development Positive Regulation Of Gene Expression Developmental Process Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Cell Death Regulation Of RNA Biosynthetic Process Response To Organic Substance Positive Regulation Of Transcription, DNA-templated Death Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Process Positive Regulation Of DNA Binding RNA Metabolic Process System Development Regulation Of Protein Ubiquitination Programmed Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Binding Myeloid Dendritic Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Metabolic Process Multicellular Organismal Development Positive Regulation Of Protein Ubiquitination Myeloid Dendritic Cell Activation	Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Proteolysis Cellular Protein Metabolic Process Activation Of MAPKK Activity Neuron Death Cellular Protein Modification Process Pronuclear Fusion Regulation Of Mitotic Cell Cycle Response To Oxidative Stress Cellular Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Modification-dependent Protein Catabolic Process SMT3-dependent Protein Catabolic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Signal Transduction Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Poly-ADP-ribosylation Collateral Sprouting In Absence Of Injury Regulation Of Growth Rate Positive Regulation Of Protein Ubiquitination Activation Of MAPK Activity Regulation Of Growth Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Proteolysis Positive Regulation Of Catalytic Activity Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Import Into Nucleus Regulation Of Signal Transduction Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		activates angiogenic biphasic colocalization colocalizes constructs depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate modulates normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels	1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd
Tagcloud (Difference) ?		activates angiogenic biphasic colocalization colocalizes constructs depend ec ecs homeobox homeodomain homeoprotein hypothesize ikappabbeta immunofluorescence implicate ingrowth modulate modulates normally p65 proangiogenic promoters rela represses secrete stimulates transduced vessels	1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hist1h3a hist1h4e hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd
Tagcloud (Intersection) ?