FAH and ETFA

Data Source: HiPPIP (Novel)

		FAH	ETFA
Name		fumarylacetoacetate hydrolase	electron transfer flavoprotein subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Mitochondrion Mitochondrial Matrix Electron Transfer Flavoprotein Complex
	Molecular Function	Catalytic Activity Fumarylacetoacetase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Electron Transfer Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	L-arginine Catabolic Process L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Lipid Metabolic Process Aromatic Amino Acid Metabolic Process Homogentisate Catabolic Process	Amino Acid Catabolic Process Respiratory Electron Transport Chain Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase
Pathways		Tyrosine catabolism	Respiratory electron transport
Drugs		Fumaric acid Acetoacetic acid 4-[Hydroxy-[Methyl-Phosphinoyl]]-3-Oxo-Butanoic Acid	None
Diseases		Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria	Glutaric acidemia; Glutaric acidemia, type I (GA1); Glutaric acidemia, type II (GA2); Multiple acyl coenzyme A dehydrogenase deficiency
GWAS		Blood protein levels ( 30072576 )	Diverticular disease ( 30177863 ) Glioma ( 28346443 ) Heel bone mineral density ( 30598549 ) Non-glioblastoma glioma ( 26424050 28346443 ) Response to tocilizumab in rheumatoid arthritis ( 22491018 )
Novel Interactors		1 novel interactors: ETFA	10 novel interactors: BNC1 CHRNA3 COX7C CSK CYP11A1 FAH LINC00597 MOV10L1 TNFRSF11A VCAM1
Interacting Genes		9 interacting genes: ADAMTSL4 CHRDL2 EGFR KRTAP10-8 KRTAP13-3 KRTAP5-9 PLEKHF2 SERTAD1 TCF4	7 interacting genes: CDC42 CFTR ETFB FBXL17 HSPB2 PSEN1 VHL
Entrez ID		2184	2108
HPRD ID		02040	01979
Ensembl ID		ENSG00000103876	ENSG00000140374
Uniprot IDs		A0A384P5L6 P16930	A0A0S2Z3L0 P13804
PDB IDs		Not available	1EFV 1T9G 2A1T 2A1U
GO Terms Enriched among Interactors		Intermediate Filament	None