ALDH2 and IGSF21

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ALDH2	IGSF21
Gene Name		aldehyde dehydrogenase 2 family (mitochondrial)	immunoglobin superfamily, member 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrial Matrix Extracellular Vesicular Exosome	Extracellular Region
	Molecular Function	Aldehyde Dehydrogenase (NAD) Activity Aldehyde Dehydrogenase [NAD(P)+] Activity Electron Carrier Activity
	Biological Process	Carbohydrate Metabolic Process Alcohol Metabolic Process Ethanol Catabolic Process Ethanol Oxidation Xenobiotic Metabolic Process Synaptic Transmission Neurotransmitter Biosynthetic Process Small Molecule Metabolic Process
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Ethanol oxidation Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Biological oxidations Serotonin clearance from the synaptic cleft Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Metabolism of serotonin Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Neurotransmitter Clearance In The Synaptic Cleft Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Transmission across Chemical Synapses
Drugs		NADH Guanidine Disulfiram Nicotinamide-Adenine-Dinucleotide Daidzin Crotonaldehyde
Diseases
GWAS		Alcohol consumption ( 21270382) Blood pressure ( 21572416) Coronary heart disease ( 23364394 21971053) Drinking behavior ( 23364009 21372407) Esophageal cancer ( 19698717) Hematological and biochemical traits ( 20139978) Intracranial aneurysm ( 22286173) mean corpuscular hemoglobin concentration ( 20139978) Renal function-related traits (sCR) ( 22797727) Stroke (ischemic) ( 23041239) Triglycerides ( 22171074) Upper aerodigestive tract cancers ( 21437268)	Diabetic retinopathy ( 21441570) Erectile dysfunction and prostate cancer treatment ( 20932654)
Protein-Protein Interactions		12 interactors: ALDH1A1 APP C14orf1 CRMP1 EIF6 FAM45B HSPD1 HSPE1 IGSF21 RPL13A SLC35F6 UNC119	32 interactors: ALDH2 ANXA3 ATF3 BCR BTBD2 CRCT1 DGKD EPB41L3 ERH ETHE1 GADD45A GIPC2 GSK3B GSTM4 HSPB1 KRAS MAD2L1BP NACA NREP PAEP PAFAH1B3 PCDHA4 PRMT1 PSMD11 RPP14 S100A8 SEPHS1 SERPINB9 SULT1E1 TMSB4X TRBV2 UBE2V2
Entrez ID		217	84966
HPRD ID		00003	11309
Ensembl ID		ENSG00000111275	ENSG00000117154
Uniprot IDs		P05091	Q96ID5
PDB IDs		1CW3 1NZW 1NZX 1NZZ 1O00 1O01 1O02 1O04 1O05 1ZUM 2ONM 2ONN 2ONO 2ONP 2VLE 3INJ 3INL 3N80 3N81 3N82 3N83 3SZ9 4FQF 4FR8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Peptidase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Proteolysis Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Formation Of Translation Preinitiation Complex B Cell Cytokine Production Isotype Switching To IgG Isotypes Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Hydrolase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cellular Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Caveolin-mediated Endocytosis Synaptic Growth At Neuromuscular Junction Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Collateral Sprouting In Absence Of Injury Cytokinesis, Completion Of Separation Sterol Metabolic Process Response To Unfolded Protein Positive Regulation Of Endopeptidase Activity Regulation Of Catalytic Activity Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Mature Ribosome Assembly Axon Choice Point Recognition Regulation Of Caveolin-mediated Endocytosis Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitotic Cytokinetic Process Pyrimidine Nucleobase Catabolic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune Response To Tumor Cell Ribosomal Subunit Export From Nucleus Neuron Remodeling Translational Initiation Protein Processing Steroid Metabolic Process	Response To Wounding Regulation Of Apoptotic Process Regulation Of Cell Death Wound Healing Positive Regulation Of Protein Metabolic Process Response To Stress Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Negative Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Response To Stimulus Developmental Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Xenobiotic Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Catabolic Process Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Nervous System Development ERBB Signaling Pathway Regulation Of Proteolysis Programmed Cell Death Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Death Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Death Cellular Response To Stimulus Blood Coagulation Platelet Activation Hemostasis Regulation Of Protein Kinase Activity Response To Biotic Stimulus Multicellular Organismal Development Positive Regulation Of Catalytic Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Kinase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Endothelial Cell Migration Regulation Of Neuronal Synaptic Plasticity Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Growth
Tagcloud ?		02e1 abnormality abuse acetaldehyde adh alcohol alcoholic alcoholism aldehyde c2 candidate cirrhosis dehydrogenase discouraged drawn favored helped inherited linkage makes metabolizing nonfibrotic pedigree polymorphisms predisposition prove virtue vulnerability
Tagcloud (Difference) ?		02e1 abnormality abuse acetaldehyde adh alcohol alcoholic alcoholism aldehyde c2 candidate cirrhosis dehydrogenase discouraged drawn favored helped inherited linkage makes metabolizing nonfibrotic pedigree polymorphisms predisposition prove virtue vulnerability
Tagcloud (Intersection) ?