FABP4 and TNFAIP3

Number of citations of the paper that reports this interaction (PubMedID 34839354)
50

Data Source:
BioGRID (two hybrid)

		FABP4	TNFAIP3
Description		fatty acid binding protein 4	TNF alpha induced protein 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Extracellular Exosome	Nucleus Cytoplasm Lysosome Cytosol Extracellular Exosome
	Molecular Function	Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Binding Lipid Binding Long-chain Fatty Acid Binding Hormone Receptor Binding	Protease Binding DNA Binding Catalytic Activity Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Enzyme Binding Kinase Binding Identical Protein Binding Ubiquitin Binding Metal Ion Binding K63-linked Deubiquitinase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Response To Bacterium Fatty Acid Transport Long-chain Fatty Acid Transport Cholesterol Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Inflammatory Response White Fat Cell Differentiation Brown Fat Cell Differentiation Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Positive Regulation Of Cold-induced Thermogenesis	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Immune System Process Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Cytoskeleton Organization Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Protein Deubiquitination Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Protein Ubiquitination Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Population Proliferation Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Triglyceride catabolism Triglyceride catabolism Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ovarian tumor domain proteases Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Metabolite levels ( 23823483) Ovarian cancer ( 23535730) Visceral fat ( 22589738)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Autoimmune traits (pleiotropy) ( 30572963) Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cutaneous psoriasis ( 26626624) Hodgkin's lymphoma ( 30194254) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Malaria ( 31844061) Multiple sclerosis ( 24076602) Phosphatidylcholine-ether levels ( 31551469) Primary biliary cholangitis ( 26394269) Psoriasis ( 25574825 19169254 25903422 20953190 23143594) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 24449572 24390342 23143596 20453841 32723749 30423114 17982456) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sjögren's syndrome ( 24097066 24097067) Systemic lupus erythematosus ( 19165918 28714469 27399966 26663301 26502338 23273568 19838195 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic sclerosis ( 28314753) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Tonsillectomy ( 28928442 27182965) Type 1 diabetes ( 34127860)
Interacting Genes		9 interacting genes: ACP1 ACTB CHD3 INSR LIPE PRKCI TNFAIP3 VIM ZBED1	61 interacting genes: ANKRD13D ARRDC3 ATP2A2 CALCOCO2 CCDC50 CCDC90B CHUK CLEC4G COL1A1 DRC4 FABP4 GIT2 GNAI2 IKBKB IKBKG LAPTM5 LNX1 MAP3K5 OCLN PCBP1 PFKL PIBF1 PSMA7 RAD23A RBCK1 RIPK1 RLIM RNF11 RNF14 RNF168 RNF216 RNF5 RPS15 RPS20 SNAI1 TAX1BP1 TICAM1 TIFA TNIP1 TNIP2 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N UBQLN1 UBXN6 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5 ZNF251
Entrez ID		2167	7128
HPRD ID		02698	01857
Ensembl ID		ENSG00000170323	ENSG00000118503
Uniprot IDs		E7DVW4 P15090	P21580
PDB IDs		1TOU 1TOW 2HNX 2NNQ 3FR2 3FR4 3FR5 3P6C 3P6D 3P6E 3P6F 3P6G 3P6H 3Q6L 3RZY 4NNS 4NNT 5D45 5D47 5D48 5D4A 5EDB 5EDC 5HZ6 5HZ8 5Y0F 5Y0G 5Y0X 5Y12 5Y13 6AYL 6LJS 6LJT 6LJU 6LJV 6LJW 6LJX 7FVU 7FVV 7FVW 7FVX 7FVY 7FVZ 7FW0 7FW1 7FW2 7FW3 7FW4 7FW5 7FW6 7FW7 7FW8 7FW9 7FWA 7FWB 7FWC 7FWD 7FWE 7FWF 7FWG 7FWH 7FWJ 7FWK 7FWL 7FWM 7FWN 7FWO 7FWP 7FWQ 7FWR 7FWS 7FWU 7FWV 7FWW 7FWX 7FWY 7FWZ 7FX0 7FX1 7FX2 7FX3 7FX4 7FX5 7FX6 7FX7 7FX8 7FX9 7FXA 7FXB 7FXC 7FXE 7FXF 7FXG 7FXH 7FXI 7FXJ 7FXK 7FXL 7FXM 7FXN 7FXP 7FXQ 7FXR 7FXS 7FXT 7FXU 7FXV 7FXW 7FXX 7FXY 7FXZ 7FY2 7FY3 7FY4 7FY5 7FY6 7FY7 7FY9 7FYB 7FYC 7FYE 7FYF 7FYG 7FYH 7FYI 7FYJ 7FYK 7FYL 7FYM 7FYO 7FYP 7FYQ 7FYR 7FYS 7FYT 7FYU 7FYV 7FYX 7FYY 7FYZ 7FZ0 7FZ1 7FZ2 7FZ3 7FZ4 7FZ5 7FZ6 7FZ7 7FZ8 7FZ9 7FZA 7FZB 7FZC 7FZD 7FZE 7FZF 7FZH 7FZI 7FZJ 7FZK 7FZL 7FZM 7FZN 7FZO 7FZP 7FZR 7FZS 7FZT 7FZU 7FZV 7FZW 7FZX 7FZY 7FZZ 7G02 7G03 7G05 7G06 7G07 7G08 7G09 7G0A 7G0C 7G0F 7G0G 7G0H 7G0I 7G0J 7G0K 7G0L 7G0M 7G0N 7G0O 7G0P 7G0Q 7G0R 7G0S 7G0T 7G0U 7G0V 7G0X 7G0Y 7G0Z 7G10 7G11 7G12 7G13 7G14 7G15 7G16 7G17 7G18 7G19 7G1A 7G1B 7G1C 7G1D 7G1E 7G1F 7G1G 7G1H 7G1I 7G1J 7G1K 7G1L 7G1M 7G1N 7G1O 7G1P 7G1R 7G1S 7G1T 7G1U 7G1V 7G1W 7G1Y 7G1Z 7G20 7G21 7WC3 8S1K 8WDX 8WE3	2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG 5LRX 5V3B 5V3P
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Cellular Response To Oxygen-containing Compound Response To Muramyl Dipeptide Extracellular Exosome Tight Junction Positive Regulation Of D-glucose Import Brush Border Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Positive Regulation Of D-glucose Transmembrane Transport Regulation Of D-glucose Import Regulation Of Endothelial Cell Apoptotic Process Cell Leading Edge Tolerance Induction To Lipopolysaccharide Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Protein Autosumoylation Hydrolase Activity Protein Modification Process Protein Phosphorylation Caveola Regulation Of D-glucose Transmembrane Transport Positive Regulation Of Cell Population Proliferation Phosphorylation Axon Regulation Of Norepinephrine Uptake Identical Protein Binding Diacylglycerol Lipase Activity Negative Regulation Of CD40 Signaling Pathway Schaffer Collateral - CA1 Synapse Structural Constituent Of Cytoskeleton Cellular Response To Insulin Stimulus Transporter Regulator Activity PML Body PTB Domain Binding Insulin Receptor Activity All-trans-retinyl-palmitate Hydrolase, All-trans-retinol Forming Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization To Plasma Membrane Regulation Of Transepithelial Transport Nuclear Matrix Insulin Receptor Complex Sterol Ester Esterase Activity Golgi Vesicle Budding Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway B-1 B Cell Homeostasis	Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Canonical NF-kappaB Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Regulation Of Intracellular Signal Transduction Ubiquitin-protein Transferase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Involved In Protein Catabolic Process Regulation Of Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin-dependent Protein Catabolic Process Cytoplasm Positive Regulation Of Intracellular Signal Transduction Macromolecule Catabolic Process Regulation Of Immune Response Protein Modification Process Cytosol Activation Of Innate Immune Response Activation Of Immune Response Protein K63-linked Ubiquitination Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Signaling Adaptor Activity Protein Metabolic Process Positive Regulation Of Signal Transduction Identical Protein Binding Catabolic Process Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Immune Response Positive Regulation Of Metabolic Process Tumor Necrosis Factor-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Defense Response Protein Sequestering Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Surface Toll-like Receptor Signaling Pathway
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