JAM3

Description		junctional adhesion molecule 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Plasma Membrane Microvillus Cell-cell Junction Bicellular Tight Junction Membrane Desmosome Filamentous Actin Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone Tight Junction Anchoring Junction Protein Complex Involved In Cell Adhesion
	Molecular Function	Integrin Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell-cell Adhesion Mediator Activity
	Biological Process	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Cell-matrix Adhesion Spermatogenesis Spermatid Development Cell Migration Transmission Of Nerve Impulse Establishment Of Cell Polarity Cell Differentiation Negative Regulation Of Integrin Activation Negative Regulation Of Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Myelination Apical Protein Localization System Development Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Hematopoietic Stem Cell Migration To Bone Marrow Granulocyte Migration Cell-cell Adhesion Protein Localization To Cell Junction Positive Regulation Of Membrane Permeability Positive Regulation Of Monocyte Extravasation
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Neutrophil count ( 32888494)
Interacting Genes		8 interacting genes: F2RL2 ITGAM ITGAX JAM2 MEOX2 PICK1 RHOU TJP1
Entrez ID		83700
HPRD ID		06042
Ensembl ID		ENSG00000166086
Uniprot IDs		Q9BX67
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Establishment Of Protein Localization Cell-cell Adhesion Integrin Binding Integrin Complex Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Tight Junction Podosome Regulation Of Myelination Positive Regulation Of Establishment Of Protein Localization Cell Adhesion Tertiary Granule Membrane Regulation Of Protein Localization Cellular Component Maintenance Plasma Membrane Regulation Of Cell Migration Anchoring Junction Proteinase-activated Receptor Activity Integrin AlphaM-beta2 Complex Integrin-mediated Signaling Pathway Regulation Of Cell Motility Integrin AlphaX-beta2 Complex Regulation Of Locomotion Positive Regulation Of Endothelial Tube Morphogenesis Cell-matrix Adhesion Regulation Of Secretion By Cell Thrombin-activated Receptor Activity Regulation Of Secretion Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Neutrophil Degranulation Response To Curcumin Complement-mediated Synapse Pruning Negative Regulation Of Catecholamine Metabolic Process Vertebrate Eye-specific Patterning Cell-substrate Adhesion Ectodermal Cell Differentiation Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Regulation Of Nervous System Process Positive Regulation Of Cell Motility Somite Specification Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Bicellular Tight Junction Membrane Curvature Sensor Activity Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion
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