PRMT3 and PABPN1

Number of citations of the paper that reports this interaction (PubMedID 10224081)
0

Data Source:
HPRD (in vitro)

		PRMT3	PABPN1
Description		protein arginine methyltransferase 3	poly(A) binding protein nuclear 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Nuclear Inclusion Body Ribonucleoprotein Complex
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Metal Ion Binding	Nucleic Acid Binding RNA Binding Protein Binding Poly(A) Binding RNA Polymerase Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Negative Regulation Of Protein Ubiquitination Methylation Positive Regulation Of Osteoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Retinoic Acid Biosynthetic Process	MAPK Cascade RNA Processing MRNA Processing Muscle Contraction Poly(A)+ MRNA Export From Nucleus Cellular Response To Lipopolysaccharide Positive Regulation Of Polynucleotide Adenylyltransferase Activity
Pathways		RMTs methylate histone arginines Protein methylation	Inhibition of Host mRNA Processing and RNA Silencing mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Z-decay: degradation of maternal mRNAs by zygotically expressed factors Nuclear RNA decay
Drugs		S-adenosyl-L-homocysteine
Diseases			Oculopharyngeal muscular dystrophy (OPMD)
GWAS		Carotid intima media thickness (maximum) ( 31801372) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906) Pursuit maintenance gain ( 29064472) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762)	Appendicular lean mass ( 33097823) Body mass index ( 26865924) Lymphocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		11 interacting genes: BEND7 FBL HNRNPA1 MEOX2 PABPN1 PIH1D2 PPARD RASSF2 STAT1 TMEM132D TSC22D2	15 interacting genes: CARM1 DNAJB4 HNRNPA1 HSP90AA1 IL7R LATS1 LINC00839 MYCBP2 OGT PRMT3 SMARCA4 SNW1 STAU1 TNPO1 YWHAQ
Entrez ID		10196	8106
HPRD ID		11934	03787
Ensembl ID		ENSG00000185238	ENSG00000100836
Uniprot IDs		O60678 Q8WUV3	G3V4T2 Q86U42
PDB IDs		2FYT 3SMQ 4HSG 4QQN 4RYL 8G2F 8G2G 8SHB 8SHR 8SIO	3B4D 3B4M 3UCG
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex	Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Ubiquitination Protein-containing Complex Regulation Of Post-translational Protein Modification Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Regulation Of Gene Expression Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Regulation Of Developmental Process Regulation Of Macromolecule Biosynthetic Process Host-mediated Activation Of Viral Transcription Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Polymerase Binding Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Protein Modification Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Transmembrane Transporter Binding Nuclear Androgen Receptor Binding Host-mediated Perturbation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Cytosol Regulation Of Synapse Assembly Histone Methyltransferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Host-mediated Activation Of Viral Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase I Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization Nucleoplasm Positive Regulation Of DNA Biosynthetic Process Regulation Of DNA Metabolic Process CTP Binding DATP Binding Positive Regulation Of Stem Cell Population Maintenance Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Macromolecule Biosynthetic Process
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