PRMT3 and BEND7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRMT3	BEND7
Description		protein arginine methyltransferase 3	BEN domain containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Extracellular Exosome
	Molecular Function	Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Histone H4R3 Methyltransferase Activity Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of DNA-templated Transcription Negative Regulation Of Protein Ubiquitination Methylation Positive Regulation Of Osteoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Negative Regulation Of Retinoic Acid Biosynthetic Process
Pathways		RMTs methylate histone arginines Protein methylation
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Carotid intima media thickness (maximum) ( 31801372) Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906) Pursuit maintenance gain ( 29064472) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Diastolic blood pressure ( 30224653) Free thyroxine concentration ( 30367059) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900) Schizophrenia x sex interaction ( 34099189) Skin pigmentation ( 28300201) Smoking status (ever vs never smokers) ( 30643258) White blood cell count ( 32888494)
Interacting Genes		11 interacting genes: BEND7 FBL HNRNPA1 MEOX2 PABPN1 PIH1D2 PPARD RASSF2 STAT1 TMEM132D TSC22D2	75 interacting genes: ANP32B BANF2 BYSL C14orf119 CDC37 CDCA7L CEP44 CHD2 CIB3 CSNK2A1 DDX6 DVL2 DVL3 EAF1 EAF2 EIF1AD EMD FAM124A FAM133A GADD45G GEMIN2 GTPBP3 GYS1 HMBOX1 HSF2BP KANK2 L3MBTL2 LMO3 LNX1 LYAR MAGOHB MBD2 MFAP1 MLX MORF4L1 MORF4L2 MYO15B NAP1L3 NEK6 NIF3L1 NKAPD1 NOL12 NUTF2 OGT OSGIN1 PBLD PIM1 PLEKHF2 POLR3GL PPIG PPP1R37 PRMT3 PRPF40A PSMB1 PSMF1 RAB29 RBM10 RIPPLY1 RPL22 SCNM1 SDCBP SDCBP2 SMARCA2 SPANXN2 THAP1 TLK1 TNPO2 TRIM26 U2AF2 UBL5 USP20 VCX2 WHRN ZCCHC10 ZNF622
Entrez ID		10196	222389
HPRD ID		11934	12570
Ensembl ID		ENSG00000185238	ENSG00000165626
Uniprot IDs		O60678 Q8WUV3	A0AAK2PQJ4 Q8N7W2
PDB IDs		2FYT 3SMQ 4HSG 4QQN 4RYL 8G2F 8G2G 8SHB 8SHR 8SIO
Enriched GO Terms of Interacting Partners?		Ribonucleoprotein Complex	Nucleoplasm Nucleus Protein Binding RNA Splicing, Via Transesterification Reactions Nuclear Speck MRNA Splicing, Via Spliceosome RNA Splicing RNA Metabolic Process Positive Regulation Of JNK Cascade Sin3-type Complex RNA Processing Nucleic Acid Metabolic Process Non-canonical Inflammasome Complex Assembly Super Elongation Complex Identical Protein Binding Positive Regulation Of Neuron Projection Arborization Frizzled Binding Regulation Of JNK Cascade Transcription Elongation Factor Activity MRNA Processing
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