HIST1H3A and KDM6B

Number of citations of the paper that reports this interaction (PMID 17713478)
212

Data Source:
BioGRID (enzymatic study)

		HIST1H3A	KDM6B
Gene Name		histone cluster 1, H3a	lysine (K)-specific demethylase 6B
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Protein Binding Beta-catenin Binding Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Chromatin Silencing At RDNA Chromatin Organization DNA Replication-dependent Nucleosome Assembly Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing	Chromatin Organization Inflammatory Response Endothelial Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesodermal Cell Differentiation Cardiac Muscle Cell Differentiation Oxidation-reduction Process Cellular Response To Hydrogen Peroxide Histone H3-K27 Demethylation
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes	Chromatin modifying enzymes Chromatin organization Oxidative Stress Induced Senescence HDMs demethylate histones Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		117 interactors: AIRE AKT2 ALL1 ANP32A ASH1L ASH2L ATRX ATXN1 ATXN7 AURKB AURKC BAZ1B CALCOCO1 CARM1 CBX1 CBX3 CHD4 COPS2 CREBBP CTCFL CUL4A DDB1 DNMT3A DPF2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FBLIM1 GATAD2A GATAD2B GRIP1 GSG2 HDAC2 HDAC8 HIST1H4A HIST2H2AC HIST2H4A HNF1B ING4 KAT2A KAT2B KAT5 KAT6A KAT7 KDM1A KDM2B KDM4A KDM4C KDM6A KDM6B KMT2A KMT2B KMT2C L3MBTL2 LBR LOXL2 MEN1 MSL3 MYOD1 NCOR1 NPM1 NR1H4 PAF1 PAK1 PARP10 PAXIP1 PBRM1 PHF1 PHF20 PHF8 PRDM2 PRKCA PRKCB PRMT1 PRMT5 PRMT7 RAD51B RAG1 RCC1 RPS6KA3 SET SETD1A SETD1B SETD2 SETD7 SETDB1 SIRT1 SIRT2 SIRT7 SMARCA2 SMARCA4 SMARCA5 SNAI1 SSRP1 SUV39H1 TAF1 TAF15 TAF1A TAF1B THAP7 TRIM24 TRIM33 TSSK6 UHRF1 UHRF2 VPRBP WHSC1 WWC1 YWHAB YWHAG YWHAZ	3 interactors: CSNK2B HIST1H3A TK1
Entrez ID		8350	23135
HPRD ID		04155	18983
Ensembl ID		ENSG00000198366	ENSG00000132510
Uniprot IDs		P68431	O15054
PDB IDs		1CS9 1CT6 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2KWJ 2KWK 2L75 2LBM 2M0O 2RI7 2UXN 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3KMT 3KQI 3LQI 3LQJ 3O34 3O35 3O37 3RIG 3RIY 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4F4U 4F56 4FWF 4HON 4I51	2XUE 2XXZ 4ASK
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Histone Modification Chromosome Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Biosynthetic Process Organelle Organization Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Macromolecule Biosynthetic Process Peptidyl-lysine Modification Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Protein Modification Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Peptidyl-amino Acid Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Histone Methylation Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Protein Methylation Cellular Metabolic Process Methylation Regulation Of Cellular Process Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic Histone Lysine Methylation Peptidyl-lysine Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression	Protein Complex Assembly Fetal Process Involved In Parturition Skeletal Muscle Cell Proliferation Cellular Component Assembly Thymidine Metabolic Process Response To Cortisol Positive Regulation Of Activin Receptor Signaling Pathway Deoxyribonucleoside Monophosphate Biosynthetic Process Adiponectin-activated Signaling Pathway DNA Replication-dependent Nucleosome Assembly Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Endothelial Tube Morphogenesis DNA Methylation On Cytosine Chromatin Silencing At RDNA Cellular Macromolecular Complex Assembly Parturition Negative Regulation Of Blood Vessel Endothelial Cell Migration Tube Development Regulation Of Gene Silencing Regulation Of Activin Receptor Signaling Pathway Response To Copper Ion Chromatin Silencing Negative Regulation Of Endothelial Cell Migration Response To Hormone Pyrimidine Nucleobase Metabolic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Blood Vessel Endothelial Cell Migration DNA Metabolic Process Negative Regulation Of Epithelial Cell Migration Pyrimidine Nucleoside Biosynthetic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation DNA Methylation Protein Homotetramerization Pyrimidine Nucleoside Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of DNA Binding DNA Modification Endothelium Development
Tagcloud ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd	1alpha 2alpha catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm3a kdm4b kdm4c lysine mesylate mimic modestly o2 rnai tri
Tagcloud (Difference) ?		1st affymetrix barcoding capn6 comprehensively corneal corneas dystrophies dystrophy fecd fecd4 fuchs genechip hcenc hspa2 hybridized itgbl1 nalcn partek polymorphous ppcd ppcd1 prex2 scientists suite tac1 tmod1 xecd	1alpha 2alpha catalyzes cocl2 demethylase demethylases demethylation desferrioxamine dimethylation elongation experiment h3k27 h3k27me3 hif hypoxia immunoprecipitation implies indicates kdm3a kdm4b kdm4c lysine mesylate mimic modestly o2 rnai tri
Tagcloud (Intersection) ?