H3C1 and NR1H4

Number of citations of the paper that reports this interaction (PubMedID 15471871)
0

Data Source:
BioGRID (enzymatic study)

		H3C1	NR1H4
Description		H3 clustered histone 1	nuclear receptor subfamily 1 group H member 4
Image
GO Annotations	Cellular Component	Nucleosome Extracellular Region Nucleus Nucleoplasm Chromosome Membrane Protein-containing Complex Extracellular Exosome	Chromatin Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Speck Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Cadherin Binding Protein Heterodimerization Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Bile Acid Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Chenodeoxycholic Acid Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Gene Expression Telomere Organization Epigenetic Regulation Of Gene Expression	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Cell-cell Junction Assembly Notch Signaling Pathway Bile Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Low-density Lipoprotein Particle Clearance Bile Acid And Bile Salt Transport Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-17 Production Toll-like Receptor 9 Signaling Pathway Regulation Of Urea Metabolic Process Intracellular Triglyceride Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Nuclear Receptor-mediated Bile Acid Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Fatty Acid Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Triglyceride Homeostasis Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Fatty Acid Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Cholesterol Metabolic Process Cellular Response To Bile Acid Positive Regulation Of Adipose Tissue Development Positive Regulation Of Phosphatidic Acid Biosynthetic Process Positive Regulation Of Glutamate Metabolic Process Positive Regulation Of Ammonia Assimilation Cycle
Pathways		Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Factors involved in megakaryocyte development and platelet production MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription	Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols
Drugs			alpha-Linolenic acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic acid Taurocholic acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh Nidufexor Tropifexor
Diseases
GWAS			Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Squamous cell carcinoma ( 23341777)
Interacting Genes		176 interacting genes: AIRE AKT2 ANAPC11 ANP32A ANP32B ASH1L ASH2L ATXN1 AURKA AURKB AURKC BARD1 BCAS3 BRCA1 CARM1 CBX1 CBX2 CBX3 CBX4 CBX5 CBX6 CBX7 CBX8 CDC20 CDYL CDYL2 CENPM CENPT CENPW CHD4 CHUK COPS2 CREBBP CTCFL CUL4A DCAF1 DDB1 DIDO1 DNMT3B DPF2 DTX2 DYRK1A EED EHMT1 EHMT2 EID1 EP300 ERCC6 ESCO1 EZH2 FANCD2 FBLIM1 GATAD2A GATAD2B GLYR1 GRIP1 H1-2 H4C14 HASPIN HAT1 HDAC1 HDAC2 HDAC3 HDAC5 HDAC8 HDGFL3 HNF1B HNRNPA1 HNRNPAB HPF1 HSPA8 ING4 JMJD6 KAT14 KAT2A KAT2B KAT5 KAT6A KAT6B KAT7 KAT8 KDM1A KDM2B KDM4A KDM4C KDM5A KDM6A KDM6B KDM8 KMT2A KMT2B KMT2C KMT2D L3MBTL2 L3MBTL3 MAD2L1 MBD5 MLLT3 MORF4L1 MPHOSPH8 MSL3 MYB NCOR1 NR1H4 NR3C1 NSD1 NSD2 NSD3 PAF1 PAK1 PALB2 PARP10 PARP2 PAXIP1 PBRM1 PHF1 PHF19 PHF20 PHF8 PIAS1 PIKFYVE PPM1D PPP1CA PPP1CB PRDM2 PRKCA PRKCB PRMT1 PRMT7 PWWP3B RAD51B RAG1 RBBP4 RBBP7 RCC1 RNF138 RPS6KA3 SETD1A SETD1B SETD2 SETD7 SETDB1 SF3B1 SHPRH SIRT1 SIRT2 SIRT3 SIRT6 SIRT7 SMARCA2 SMARCA5 SMYD5 SUPT16H SUV39H1 SUV39H2 TAF15 TAF1A TAF1B TAF3 THAP7 TLE3 TMEM132D TRIM24 TRIM33 TSPYL2 TSPYL5 TSSK6 UBR7 UHRF1 UHRF2 USP7 WDR5 WWC1 YEATS4 YWHAB YWHAG	15 interacting genes: CASP8 EP300 ESR1 GAPDH GRIN1 H3C1 NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRG SIRT1 SMARCD1 SMARCD3
Entrez ID		8350	9971
HPRD ID		04155	04827
Ensembl ID		ENSG00000275714	ENSG00000012504
Uniprot IDs		P68431	B6ZGS9 F1DAL1 Q96RI1
PDB IDs		1CS9 1CT6 1O9S 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CO0 2CV5 2FSA 2KWJ 2KWK 2L75 2LBM 2LGG 2M0O 2NDF 2NDG 2OQ6 2OT7 2OX0 2RI7 2RR4 2UXN 2V85 2V89 2VNF 2VPG 2X0L 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3FDT 3KMT 3KQI 3LQI 3LQJ 3MP1 3O34 3O35 3O37 3QJ6 3RIG 3RIY 3SOU 3SOW 3U31 3U3D 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3X1S 3X1T 3X1U 3X1V 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4C1Q 4F4U 4F56 4FWF 4HON 4I51 4L7X 4LK9 4LKA 4LLB 4LXL 4N4H 4QBQ 4QBR 4QBS 4TN7 4U68 4UP0 4UY4 4X3K 4Y6L 4YHP 4YHZ 4YM5 4YM6 4Z0R 4Z2M 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5B24 5B2I 5B2J 5B31 5C11 5C13 5C3I 5CPI 5CPJ 5CPK 5D6Y 5DAH 5FB0 5FB1 5FFV 5GH9 5GSE 5GSU 5GT0 5GT3 5GTC 5H6Q 5H6R 5HJB 5HJC 5HJD 5HYN 5IQL 5J3V 5J9S 5JHN 5JIN 5JIY 5JJ0 5JRG 5KJH 5KJI 5KKL 5LUG 5M5G 5MR8 5NNC 5NND 5OY3 5SVX 5SVY 5SZB 5SZC 5T0K 5T0M 5T1G 5T1I 5T8R 5TBN 5TDR 5TDW 5U2J 5V21 5V22 5VA6 5VAB 5VGE 5VNB 5WFC 5WLE 5WVO 5WXG 5WXH 5WYI 5X60 5XF3 5XF4 5XF5 5XFQ 5XFR 5XNV 5XTZ 5Y0C 5Y0D 5Y20 5Y2F 5Z23 5Z30 6AXJ 6AZE 6BHD 6BHE 6BHG 6BHH 6BHI 6D07 6D08 6E83 6E86 6F6D 6HKT 6HTS 6IEU 6IIS 6IIT 6IPU 6IQ4 6JOU 6JR0 6JR1 6JXD 6K1I 6K1J 6K1K 6KE9 6KVD 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6LS6 6LSD 6M3V 6M44 6M4D 6M4G 6M4H 6MIL 6MIM 6MIN 6MIO 6MIQ 6PA1 6PAG 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T90 6T93 6UPK 6UPL 6USJ 6V2H 6V2K 6V3N 6V41 6V92 6VIL 6WAV 6WW4 6YIF 6YIH 6YOV 7BWD 7C0M 7CCQ 7CCR 7CFP 7CFQ 7COW 7D1Z 7DBP 7E8D 7EBK 7K5X 7K5Y 7K60 7K61 7K63 7KLR 7LBK 7LBO 7LBP 7LBQ 7LYA 7LYB 7LYC 7MJU 7NL0 7SCY 7SCZ 7TD5 7U0G 7U0I 7U0J 7V6Q 7V90 7V96 7V9C 7V9J 7V9K 7V9S 7VA4 7VZ4 7W9V 7X57 7X58 7XD1 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y5U 7Y5V 7Y5W 7Y60 7Y61 7Y7I 7Y8R 7YOZ 7YQK 7ZI4 8DK5 8DS8 8EVG 8EVH 8EVI 8EVJ 8GE0 8GRM 8GUI 8GUJ 8GUK 8H0V 8H0W 8H1T 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HLY 8HMX 8I60 8IEG 8IEJ 8IHL 8IIY 8IIZ 8IJ0 8IQF 8IQG 8J6S 8J6T 8JBX 8JCC 8JCD 8JHF 8JHG 8JL9 8JLA 8JND 8JNE 8JNF 8KCY 8KD1 8KE0 8OFF 8OO7 8OOA 8OOP 8OOS 8OSJ 8OSK 8OSL 8OTS 8OTT 8OX0 8OX1 8Q36 8Q3E 8Q3M 8Q3X 8QKT 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8SPS 8SPU 8SWI 8SYP 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8VMI 8VML 8VNV 8W9D 8W9E 8W9F 8WG5 8X15 8X19 8X1C 8XBT 8XBU 8XBW 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YJF 8YJM 8YNY 8YTI 8YV8 9FGQ 9FH9 9J8M 9J8N 9J8O	1OSH 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4OIV 4QE8 4WVD 5IAW 5ICK 5Q0I 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q17 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5WZX 5Y1J 5Y44 5Y49 5YXB 5YXD 5YXJ 5YXL 5Z12 6A5W 6A5X 6A5Y 6A5Z 6A60 6HL0 6HL1 6ITM 7D42 7TRB 7VUE 8HBM 8HD3
Enriched GO Terms of Interacting Partners?		Chromatin Organization Chromatin Remodeling Nucleoplasm Nucleus Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Heterochromatin Formation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Histone Binding Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Histone Methyltransferase Activity Transferase Activity Protein Modification Process Histone H3 Methyltransferase Activity Zinc Ion Binding Methyltransferase Activity DNA Damage Response Regulation Of DNA Metabolic Process Cellular Response To Stress Methylation Negative Regulation Of Gene Expression Histone Methyltransferase Complex	Nuclear Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Transcription Coactivator Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Rhythmic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Retinoid X Receptor Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nuclear Steroid Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway Developmental Process Myeloid Cell Differentiation Response To Estradiol Regulation Of RNA Metabolic Process Nucleus Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Glucose Metabolic Process Chromatin Organization Transcription Coregulator Activity Nuclear Estrogen Receptor Binding Nucleobase-containing Compound Biosynthetic Process Regulation Of Multicellular Organismal Process Nervous System Development Cell Differentiation Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Hexose Metabolic Process
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