EPHX2 and PEX5

Number of citations of the paper that reports this interaction (PMID 20178365)
7

Data Source:
BioGRID (unspecified method)

		EPHX2	PEX5
Gene Name		epoxide hydrolase 2, cytoplasmic	peroxisomal biogenesis factor 5
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Extracellular Vesicular Exosome	Intracellular Cytoplasm Peroxisome Peroxisomal Membrane Peroxisomal Matrix Golgi Apparatus Cytosol Membrane Protein Complex
	Molecular Function	Magnesium Ion Binding Epoxide Hydrolase Activity Receptor Binding Toxic Substance Binding Phosphatase Activity 10-hydroxy-9-(phosphonooxy)octadecanoate Phosphatase Activity Lipid Phosphatase Activity Protein Homodimerization Activity	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Protein C-terminus Binding Enzyme Binding Small GTPase Binding Protein N-terminus Binding
	Biological Process	Xenobiotic Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Regulation Of Blood Pressure Response To Toxic Substance Positive Regulation Of Gene Expression Dephosphorylation Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Cholesterol Homeostasis Small Molecule Metabolic Process Positive Regulation Of Vasodilation Stilbene Catabolic Process Phospholipid Dephosphorylation Reactive Oxygen Species Metabolic Process Regulation Of Cholesterol Metabolic Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Matrix, Translocation Protein Import Into Peroxisome Membrane Protein Tetramerization Negative Regulation Of Protein Homotetramerization
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Drugs		N-Cyclohexyl-N\'-(4-Iodophenyl)Urea N-Cyclohexyl-N\'-Decylurea N-Cyclohexyl-N\'-(Propyl)Phenyl Urea N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID
Diseases
GWAS		Dental caries ( 23259602)	IgG glycosylation ( 23382691)
Protein-Protein Interactions		4 interactors: MVP NIPSNAP3A PEX5 TERF1	68 interactors: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECH1 ECI2 EP400NL EPHX2 FIS1 GDPD5 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PECR PEX10 PEX12 PEX13 PEX14 PEX7 PIPOX POT1 PRDX5 PRR13 RPL14 S100A6 SCARB1 SCP2 SIRT3 SLC27A2 SNUPN SSTR5 TINF2 TM6SF1 TOMM7 USP9X ZNF772
Entrez ID		2053	5830
HPRD ID		00582	02684
Ensembl ID		ENSG00000120915	ENSG00000139197
Uniprot IDs		P34913	B4DR50 B4E0T2 P50542
PDB IDs		1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 4HAI 4J03 4JNC	1FCH 2C0L 2C0M 2J9Q 2W84 3R9A
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Negative Regulation Of Protein Homooligomerization Negative Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Protein Oligomerization Peroxisomal Membrane Transport Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Microtubule Polymerization Protein Import Into Peroxisome Matrix Regulation Of Telomerase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Negative Regulation Of Catalytic Activity Very Long-chain Fatty Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Regulation Of Microtubule Polymerization Regulation Of Protein Autophosphorylation Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Endoplasmic Reticulum Organization Negative Regulation Of Chromosome Segregation Fatty Acid Beta-oxidation Peroxisome Organization Protein Complex Assembly	Carboxylic Acid Catabolic Process Monocarboxylic Acid Metabolic Process Fatty Acid Metabolic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Small Molecule Metabolic Process Fatty Acid Oxidation Catabolic Process Lipid Oxidation Fatty Acid Catabolic Process Lipid Metabolic Process Cellular Lipid Metabolic Process Lipid Modification Cellular Lipid Catabolic Process Lipid Catabolic Process Peroxisome Organization Oxidation-reduction Process Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Protein Import Into Peroxisome Matrix Cellular Metabolic Process Acyl-CoA Metabolic Process Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Bile Acid Biosynthetic Process Intracellular Protein Transmembrane Transport Cofactor Metabolic Process Protein Transmembrane Transport Lipid Biosynthetic Process Bile Acid Metabolic Process Fatty Acid Alpha-oxidation Sulfur Compound Metabolic Process Glyoxylate Metabolic Process Protein Import Protein Localization To Organelle Establishment Of Protein Localization To Organelle Steroid Biosynthetic Process Protein Targeting Telomere Assembly Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Steroid Metabolic Process Cellular Amino Acid Catabolic Process Long-chain Fatty Acid Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization Cellular Process Dicarboxylic Acid Catabolic Process Coenzyme A Catabolic Process
Tagcloud ?		25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp cyp2c8 cyp2c9 cyp2j2 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid	behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled
Tagcloud (Difference) ?		25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp cyp2c8 cyp2c9 cyp2j2 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid	behave behaves cargo cooperatively couple cytosol deubiquitination differently disuse energetics folded identically import importers importomer lumen organelles peroxisomal peroxisome peroxisomes pexophagy shuttle stochastic traffic translationally translocated translocation ubiquitin uncoupled
Tagcloud (Intersection) ?