EPHX2 and MVP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EPHX2	MVP
Gene Name		epoxide hydrolase 2, cytoplasmic	major vault protein
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Extracellular Vesicular Exosome	Nucleus Nuclear Pore Cytoplasm Cytoskeleton Membrane Ribonucleoprotein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Epoxide Hydrolase Activity Receptor Binding Toxic Substance Binding Phosphatase Activity 10-hydroxy-9-(phosphonooxy)octadecanoate Phosphatase Activity Lipid Phosphatase Activity Protein Homodimerization Activity	Protein Binding Protein Kinase Binding Protein Phosphatase Binding
	Biological Process	Xenobiotic Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Regulation Of Blood Pressure Response To Toxic Substance Positive Regulation Of Gene Expression Dephosphorylation Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Cholesterol Homeostasis Small Molecule Metabolic Process Positive Regulation Of Vasodilation Stilbene Catabolic Process Phospholipid Dephosphorylation Reactive Oxygen Species Metabolic Process Regulation Of Cholesterol Metabolic Process	Cell Proliferation Protein Transport Negative Regulation Of Signaling Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity Protein Activation Cascade
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Drugs		N-Cyclohexyl-N\'-(4-Iodophenyl)Urea N-Cyclohexyl-N\'-Decylurea N-Cyclohexyl-N\'-(Propyl)Phenyl Urea N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID
Diseases
GWAS		Dental caries ( 23259602)
Protein-Protein Interactions		4 interactors: MVP NIPSNAP3A PEX5 TERF1	57 interactors: ADAMTSL4 AES BANP BZRAP1 C1orf94 CALCOCO2 CAMK2B CCDC36 CKAP4 CYTB DISC1 DLX2 EPHX2 ESR1 FAM154A FAM46C GIT2 GOLGA2 HP KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MKL1 NNT NOTCH2NL OBFC1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SERTAD1 SKIL SLC2A4 TCF4 TFCP2 TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 VAC14 ZBTB32 ZMIZ2
Entrez ID		2053	9961
HPRD ID		00582	05475
Ensembl ID		ENSG00000120915	ENSG00000013364
Uniprot IDs		P34913	B4DP93 Q14764
PDB IDs		1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 4HAI 4J03 4JNC	1Y7X
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Negative Regulation Of Protein Homooligomerization Negative Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Protein Oligomerization Peroxisomal Membrane Transport Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Microtubule Polymerization Protein Import Into Peroxisome Matrix Regulation Of Telomerase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Negative Regulation Of Catalytic Activity Very Long-chain Fatty Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Regulation Of Microtubule Polymerization Regulation Of Protein Autophosphorylation Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Endoplasmic Reticulum Organization Negative Regulation Of Chromosome Segregation Fatty Acid Beta-oxidation Peroxisome Organization Protein Complex Assembly	Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Signaling Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Cytokine RNA Metabolic Process Defense Response Positive Regulation Of Cellular Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Response To Stress Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Immune System Process Nitrogen Compound Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Organic Substance Positive Regulation Of Apoptotic Process Protein Localization To Nucleus Positive Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Regulation Of Intracellular Signal Transduction Cellular Metabolic Process Regulation Of Cell Death Negative Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?		25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp cyp2c8 cyp2c9 cyp2j2 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Difference) ?		25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp cyp2c8 cyp2c9 cyp2j2 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid	afp bleomycin bronchogenic cap chance cisplatin cooperative crs cyclophosphamide doxorubicin eastern ecog efficacious entered est evaluable fluorouracil institution lethal mitomycin modest nscbc october oncology prs regimens shrinkage threatening vinblastine
Tagcloud (Intersection) ?