EPHX2

Gene Name		epoxide hydrolase 2, cytoplasmic
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Gene Ontology Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Epoxide Hydrolase Activity Receptor Binding Toxic Substance Binding Phosphatase Activity 10-hydroxy-9-(phosphonooxy)octadecanoate Phosphatase Activity Lipid Phosphatase Activity Protein Homodimerization Activity
	Biological Process	Xenobiotic Metabolic Process Cellular Calcium Ion Homeostasis Inflammatory Response Regulation Of Blood Pressure Response To Toxic Substance Positive Regulation Of Gene Expression Dephosphorylation Drug Metabolic Process Arachidonic Acid Metabolic Process Epoxygenase P450 Pathway Cholesterol Homeostasis Small Molecule Metabolic Process Positive Regulation Of Vasodilation Stilbene Catabolic Process Phospholipid Dephosphorylation Reactive Oxygen Species Metabolic Process Regulation Of Cholesterol Metabolic Process
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Drugs		N-Cyclohexyl-N\'-(4-Iodophenyl)Urea N-Cyclohexyl-N\'-Decylurea N-Cyclohexyl-N\'-(Propyl)Phenyl Urea N-[(CYCLOHEXYLAMINO)CARBONYL]GLYCINE 4-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}BUTANOIC ACID 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID
Diseases
GWAS		Dental caries ( 23259602)
Protein-protein Interactions		4 interactors: MVP NIPSNAP3A PEX5 TERF1
Entrez ID		2053
HPRD ID		00582
Ensembl ID		ENSG00000120915
Uniprot IDs		P34913
PDB IDs		1S8O 1VJ5 1ZD2 1ZD3 1ZD4 1ZD5 3ANS 3ANT 3I1Y 3I28 3KOO 3OTQ 3PDC 4HAI 4J03 4JNC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Negative Regulation Of Protein Homooligomerization Negative Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Protein Oligomerization Peroxisomal Membrane Transport Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Microtubule Polymerization Protein Import Into Peroxisome Matrix Regulation Of Telomerase Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Negative Regulation Of Catalytic Activity Very Long-chain Fatty Acid Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Regulation Of Microtubule Polymerization Regulation Of Protein Autophosphorylation Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Positive Regulation Of Mitotic Nuclear Division Endoplasmic Reticulum Organization Negative Regulation Of Chromosome Segregation Fatty Acid Beta-oxidation Peroxisome Organization Protein Complex Assembly
Tagcloud ?		25369t 287gln 2c 36755a 36785a 404del 55arg 816g aneurysmal asah bonferroni cnd cyp cyp2c8 cyp2c9 cyp2j2 dci dhet dihydroxyeicosatetraenoic eet eets eicosanoid epoxyeicosatrienoic jcbfm journal mrs passed rankin subarachnoid