HIPK1 and RUNX1

Number of citations of the paper that reports this interaction (PMID 16917507)
29

Data Source:
HPRD (in vivo)

		HIPK1	RUNX1
Gene Name		homeodomain interacting protein kinase 1	runt-related transcription factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body Nuclear Speck	Basement Membrane Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Regulatory Region DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Repressing Transcription Factor Binding
	Biological Process	Eye Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Retina Layer Formation Neuron Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Angiogenesis Embryonic Camera-type Eye Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Definitive Hemopoiesis Lens Induction In Camera-type Eye Iris Morphogenesis Endothelial Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway	Skeletal System Development In Utero Embryonic Development Liver Development Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Central Nervous System Development Regulation Of Signal Transduction Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Hair Follicle Morphogenesis Embryonic Hemopoiesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Response To Pain Peripheral Nervous System Neuron Development Definitive Hemopoiesis Regulation Of Hair Follicle Cell Proliferation Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Progesterone Secretion
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Breast cancer ( 23535729)	Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22542470) Phospholipid levels (plasma) ( 21829377) Preeclampsia ( 23551011)
Protein-Protein Interactions		13 interactors: ATP13A2 DAXX FHL3 GLUL HOXD4 NKX2-5 PARK7 PRPF40A RUNX1 SKIL SNIP1 TP53 UBE2I	46 interactors: AES AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COPRS CTBP2 DNMT1 EFNA2 ELF2 ELF4 EP300 ETS1 FOS FOXP3 HDAC1 HDAC3 HIPK1 HIPK2 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 PAX5 PRMT1 RBM14 SPEN STUB1 SUV39H1 TAZ TLE1 TLE2 UBE2L6 UXT VDR WWTR1 YAP1
Entrez ID		204851	861
HPRD ID		06418	01043
Ensembl ID		ENSG00000163349	ENSG00000159216
Uniprot IDs		B4DZ33 Q86Z02	Q01196
PDB IDs			1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neurotransmitter Uptake Positive Regulation Of Transport Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Toxic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Gene Expression Response To Transforming Growth Factor Beta Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Muscle Cell Apoptotic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Muscle Organ Development Positive Regulation Of Transporter Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Death Cell Proliferation Negative Regulation Of Biosynthetic Process Cell Cycle Response To Antibiotic Negative Regulation Of Cell Differentiation Nitrogen Compound Metabolic Process Organelle Organization Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Atrioventricular Node Cell Fate Commitment Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Developmental Process System Development Regulation Of Cellular Process Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Notch Signaling Pathway Chromatin Organization Cellular Metabolic Process Chromatin Modification Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cell Differentiation Response To Organic Substance
Tagcloud ?		1gamma chromo ddr dead doi flag gammah2a h3k9me3 hct116 hipk2 homeodomain hp1 hp1alpha hp1beta hp1box hp1gamma lys9 onc phosphorylating ptvsv ser139 shadow silenced sublethal tagged trimethylated ultraviolet uncover uv	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated
Tagcloud (Difference) ?		1gamma chromo ddr dead doi flag gammah2a h3k9me3 hct116 hipk2 homeodomain hp1 hp1alpha hp1beta hp1box hp1gamma lys9 onc phosphorylating ptvsv ser139 shadow silenced sublethal tagged trimethylated ultraviolet uncover uv	1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated
Tagcloud (Intersection) ?