HIPK1 and ATP13A2

Number of citations of the paper that reports this interaction (PMID 22645275)
9

Data Source:
BioGRID (two hybrid)

		HIPK1	ATP13A2
Gene Name		homeodomain interacting protein kinase 1	ATPase type 13A2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm PML Body Nuclear Speck	Lysosome Lysosomal Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Binding ATP Binding ATPase Activity Metal Ion Binding
	Biological Process	Eye Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Retina Layer Formation Neuron Differentiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Angiogenesis Embryonic Camera-type Eye Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Definitive Hemopoiesis Lens Induction In Camera-type Eye Iris Morphogenesis Endothelial Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway	Cation Transport Metabolic Process Cellular Response To Manganese Ion
Pathways		Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Breast cancer ( 23535729)	Height ( 20189936)
Protein-Protein Interactions		13 interactors: ATP13A2 DAXX FHL3 GLUL HOXD4 NKX2-5 PARK7 PRPF40A RUNX1 SKIL SNIP1 TP53 UBE2I	36 interactors: ACKR3 ATP5G2 CCKBR CMTM6 COL1A1 CXCR4 CYGB DCAF7 EMC7 F2R FAM111B FAM192A FAM8A1 FKBP8 FUNDC2 GPR21 HIPK1 ICAM2 LMAN2 LRP6 MEX3B MYCBP2 NPY1R NRXN1 OCA2 OSTC PCDHB10 PCMTD2 PDIA6 SEC61B SPCS2 TSPAN14 UBE2J2 VAMP2 WDR5B WDR83OS
Entrez ID		204851	23400
HPRD ID		06418	13677
Ensembl ID		ENSG00000163349	ENSG00000159363
Uniprot IDs		B4DZ33 Q86Z02	Q9NQ11
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Neurotransmitter Uptake Positive Regulation Of Transport Regulation Of Signaling Regulation Of Transcription, DNA-templated Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Toxic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Gene Expression Response To Transforming Growth Factor Beta Positive Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Muscle Cell Apoptotic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Muscle Organ Development Positive Regulation Of Transporter Activity Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Neuron Death Cell Proliferation Negative Regulation Of Biosynthetic Process Cell Cycle Response To Antibiotic Negative Regulation Of Cell Differentiation Nitrogen Compound Metabolic Process Organelle Organization Positive Regulation Of L-dopa Decarboxylase Activity Positive Regulation Of L-dopa Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Atrioventricular Node Cell Fate Commitment Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway	Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Protein Localization To Membrane Embryonic Retina Morphogenesis In Camera-type Eye Establishment Of Protein Localization To Membrane Regulation Of Signaling Establishment Of Protein Localization Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Membrane Organization Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cardiovascular System Development Synaptic Transmission Motor Neuron Axon Guidance Cell-cell Signaling Locomotion Positive Regulation Of Signal Transduction Chemotaxis Face Morphogenesis Embryonic Camera-type Eye Morphogenesis ER-associated Ubiquitin-dependent Protein Catabolic Process Head Morphogenesis Positive Regulation Of Wnt Signaling Pathway Involved In Dorsal/ventral Axis Specification Canonical Wnt Signaling Pathway Involved In Cardiac Neural Crest Cell Differentiation Involved In Heart Development Negative Regulation Of Planar Cell Polarity Pathway Involved In Neural Tube Closure Negative Regulation Of Planar Cell Polarity Pathway Involved In Outflow Tract Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Pericardium Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Right Atrium Morphogenesis Negative Regulation Of Renin Secretion Into Blood Stream Negative Regulation Of Planar Cell Polarity Pathway Involved In Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Planar Cell Polarity Pathway Involved In Ventricular Septum Morphogenesis Cellular Response To Fluoride Protein Complex Assembly Involved In Synapse Maturation Gamma-aminobutyric Acid Receptor Clustering Tyrosine Transport Synapse Organization Protein Localization To Nucleus Embryonic Eye Morphogenesis Cellular Protein Localization Regulation Of Protein Secretion Cellular Metal Ion Homeostasis Response To External Stimulus Cellular Homeostasis Cerebellum Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Face Development Regulation Of Signal Transduction Cellular Protein Metabolic Process Regulation Of Insulin Secretion
Tagcloud ?		1gamma chromo ddr dead doi flag gammah2a h3k9me3 hct116 hipk2 homeodomain hp1 hp1alpha hp1beta hp1box hp1gamma lys9 onc phosphorylating ptvsv ser139 shadow silenced sublethal tagged trimethylated ultraviolet uncover uv	ataxin atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Difference) ?		1gamma chromo ddr dead doi flag gammah2a h3k9me3 hct116 hipk2 homeodomain hp1 hp1alpha hp1beta hp1box hp1gamma lys9 onc phosphorylating ptvsv ser139 shadow silenced sublethal tagged trimethylated ultraviolet uncover uv	ataxin atxn3 b12 cag cgg chediak coexist cytopathies fmr1 fragile gaucher gba glucocerebrosidase hereditary higashi idiopathic joseph kufor levodopa lyst machado park2 parkin parkinsonism pn polg1 premutation rakeb tremor
Tagcloud (Intersection) ?