ARL13B and KCNJ2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARL13B	KCNJ2
Description		ARF like GTPase 13B	potassium inwardly rectifying channel subfamily J member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Motile Cilium Ciliary Basal Body Cell Projection Intercellular Bridge Ciliary Membrane Non-motile Cilium	Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc Membrane T-tubule Dendrite Monoatomic Ion Channel Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Inward Rectifier Potassium Channel Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Heart Looping Smoothened Signaling Pathway Determination Of Left/right Symmetry Dorsal/ventral Pattern Formation Neural Tube Patterning Interneuron Migration From The Subpallium To The Cortex Formation Of Radial Glial Scaffolds Cilium Assembly Left/right Axis Specification Receptor Localization To Non-motile Cilium Non-motile Cilium Assembly	Monoatomic Ion Transport Potassium Ion Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Intracellular Potassium Ion Homeostasis Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		ARL13B-mediated ciliary trafficking of INPP5E RHOQ GTPase cycle RHOJ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Sensory perception of sour taste Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ranolazine Miconazole Carvedilol Dronedarone
Diseases		Joubert syndrome	Short QT syndrome Andersen-Tawil syndrome (ATS) Atrial fibrillation Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS			Adolescent idiopathic scoliosis (severe) ( 24023777) Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Chin dimples ( 27182965) Dentures ( 31235808) Depressive episodes in bipolar disorder ( 26297903) Early cardiac repolarization ( 22342860) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Formal thought disorder in schizophrenia ( 22648509) HDL cholesterol levels ( 32109663 32203549) Hip circumference adjusted for BMI ( 25673412) Liver enzyme levels (alanine transaminase) ( 33972514) Lung function (forced vital capacity) ( 24929828) Macular thickness ( 30535121) Metabolite levels ( 23823483) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 20195514 23704328) Primary tooth development (time to first tooth eruption) ( 20195514 23704328) Prudent dietary pattern ( 28644415) Pulmonary function (smoking interaction) ( 23284291) QT interval ( 19305409 29874175 30679814 24952745) Refractive error ( 23396134) Renal overload gout ( 32238385) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Thyrotoxic periodic paralysis ( 33105104) TPE interval (response to exercise) ( 32386560) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549)
Interacting Genes		146 interacting genes: ACSF2 AIG1 ALG3 ANKRD46 AOC3 AQP10 ARLN B4GALNT2 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C1GALT1 C2CD2L CCDC167 CCL4 CCL4L2 CD151 CD302 CD53 CDIPT CFHR5 CLDN4 CLDN8 CLEC4G CLEC7A CLN6 CMTM3 CMTM7 COL8A2 CSGALNACT2 CTSA CXCL16 CYB561D2 EBP EMP1 ENTPD3 ERG28 FAXDC2 FDFT1 FKBP8 FUNDC2 FXYD6 GAD2 GIMAP1 GIMAP5 GJB2 GOSR2 GPR37L1 HMOX1 HMOX2 HOMER3 ICMT IGFBP5 INSIG2 ITGAM JAGN1 KCNJ2 KLRG1 LEPROTL1 LHFPL5 LPAR3 MAL2 MALL MMD MOSPD3 MUCL1 MYADML2 NAT8 NINJ2 NKG7 NRM NUCB2 ORMDL1 ORMDL3 PAEP PDZK1IP1 PGAP2 PKNOX1 PLN PLP1 PLP2 PLPP4 PLPPR2 PMP22 PNLIPRP1 PRB1 PTPN9 RTP2 RUSF1 S100A2 SACM1L SEMA4G SLC13A3 SLC2A5 SLC35A1 SLC35B1 SLC38A7 SLC39A2 SMAGP SMCO4 SPN STRIT1 STX1A STX7 STX8 TECR TEX264 TFRC THSD7A THSD7B TM6SF2 TMEM11 TMEM120B TMEM121 TMEM128 TMEM14B TMEM14C TMEM187 TMEM190 TMEM218 TMEM229B TMEM254 TMEM43 TMEM54 TMEM60 TMEM65 TMEM79 TMEM86B TMEM97 TMUB2 TNFRSF10C TNMD TRARG1 TSPO2 UBE2I VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VSTM1 WFDC2 YIPF6 ZDHHC15	20 interacting genes: AKAP5 ARL13B CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 KCNJ11 KCNJ15 KCNJ16 KCNJ18 KCNJ4 KCNJ8 PATJ SDC3 SDCBP SEC22A TRAK2
Entrez ID		200894	3759
HPRD ID		12334	02815
Ensembl ID		ENSG00000169379	ENSG00000123700
Uniprot IDs		A0A7P0T892 A0A7P0T933 A0A7P0Z473 Q3SXY8	P63252
PDB IDs			6SPZ 7ZDZ 8QQL
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding SNAP Receptor Activity SNARE Complex Assembly Plasma Membrane Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Establishment Of Protein Localization To Plasma Membrane Endomembrane System Chloride Channel Inhibitor Activity Sterol Biosynthetic Process Bleb Assembly Heme Oxidation Heme Oxygenase (decyclizing) Activity Structural Constituent Of Myelin Sheath Membrane Fusion Specific Granule Membrane Establishment Of Protein Localization To Membrane Vesicle Organization Membrane Organization Myelination Axon Ensheathment Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Heme Metabolic Process SNARE Binding Identical Protein Binding Transport Vesicle Golgi To Plasma Membrane Protein Transport Lipid Metabolic Process Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Porphyrin-containing Compound Metabolic Process Lipid Homeostasis Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Inward Rectifier Potassium Channel Activity Regulation Of Monoatomic Ion Transport Potassium Ion Import Across Plasma Membrane Regulation Of Monoatomic Ion Transmembrane Transport Plasma Membrane Inorganic Cation Import Across Plasma Membrane Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Monoatomic Ion Channel Complex Import Across Plasma Membrane Potassium Ion Transmembrane Transport Establishment Or Maintenance Of Cell Polarity Voltage-gated Potassium Channel Complex Potassium Ion Transport Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Kinase Binding GMP Kinase Activity GDP Metabolic Process Metal Ion Transport Receptor Localization To Synapse Basolateral Plasma Membrane Protein Localization To Synapse Protein Localization To Membrane Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Monoatomic Cation Transport Localization Within Membrane Trans-synaptic Signaling Neuromuscular Junction Adherens Junction Synaptic Signaling GMP Metabolic Process Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transport Postsynaptic Density Membrane Formation Of Radial Glial Scaffolds Inward Rectifying Potassium Channel Response To Resveratrol Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Cellular Localization Regulation Of Metal Ion Transport Cell-cell Signaling Response To Stilbenoid
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