ARL13B and SACM1L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARL13B	SACM1L
Description		ARF like GTPase 13B	SAC1 like phosphatidylinositide phosphatase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Motile Cilium Ciliary Basal Body Cell Projection Intercellular Bridge Ciliary Membrane Non-motile Cilium	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity
	Biological Process	Heart Looping Smoothened Signaling Pathway Determination Of Left/right Symmetry Dorsal/ventral Pattern Formation Neural Tube Patterning Interneuron Migration From The Subpallium To The Cortex Formation Of Radial Glial Scaffolds Cilium Assembly Left/right Axis Specification Receptor Localization To Non-motile Cilium Non-motile Cilium Assembly	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Dephosphorylation Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Vesicle-mediated Transport In Synapse
Pathways		ARL13B-mediated ciliary trafficking of INPP5E RHOQ GTPase cycle RHOJ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Synthesis of PIPs at the ER membrane Synthesis of PIPs at the Golgi membrane
Drugs
Diseases		Joubert syndrome
GWAS			Acne (severe) ( 24927181) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Macular telangiectasia type 2 ( 33654266) Response to anti-depressant treatment in major depressive disorder ( 22041458) Serum metabolite levels ( 33031748) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		146 interacting genes: ACSF2 AIG1 ALG3 ANKRD46 AOC3 AQP10 ARLN B4GALNT2 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C1GALT1 C2CD2L CCDC167 CCL4 CCL4L2 CD151 CD302 CD53 CDIPT CFHR5 CLDN4 CLDN8 CLEC4G CLEC7A CLN6 CMTM3 CMTM7 COL8A2 CSGALNACT2 CTSA CXCL16 CYB561D2 EBP EMP1 ENTPD3 ERG28 FAXDC2 FDFT1 FKBP8 FUNDC2 FXYD6 GAD2 GIMAP1 GIMAP5 GJB2 GOSR2 GPR37L1 HMOX1 HMOX2 HOMER3 ICMT IGFBP5 INSIG2 ITGAM JAGN1 KCNJ2 KLRG1 LEPROTL1 LHFPL5 LPAR3 MAL2 MALL MMD MOSPD3 MUCL1 MYADML2 NAT8 NINJ2 NKG7 NRM NUCB2 ORMDL1 ORMDL3 PAEP PDZK1IP1 PGAP2 PKNOX1 PLN PLP1 PLP2 PLPP4 PLPPR2 PMP22 PNLIPRP1 PRB1 PTPN9 RTP2 RUSF1 S100A2 SACM1L SEMA4G SLC13A3 SLC2A5 SLC35A1 SLC35B1 SLC38A7 SLC39A2 SMAGP SMCO4 SPN STRIT1 STX1A STX7 STX8 TECR TEX264 TFRC THSD7A THSD7B TM6SF2 TMEM11 TMEM120B TMEM121 TMEM128 TMEM14B TMEM14C TMEM187 TMEM190 TMEM218 TMEM229B TMEM254 TMEM43 TMEM54 TMEM60 TMEM65 TMEM79 TMEM86B TMEM97 TMUB2 TNFRSF10C TNMD TRARG1 TSPO2 UBE2I VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VSTM1 WFDC2 YIPF6 ZDHHC15	36 interacting genes: ACKR2 AQP6 ARL13B CD79A COPA COPB2 COPG1 CREB3 CREB3L1 DHRS7 EBP FAM209A FFAR2 FMO3 GPR151 GPR152 HSD17B13 JAGN1 LMNA MFF MTERF2 ODF4 PRKCA RNF19B RTN3 SCN3B SLC10A1 SLC10A6 SLC35A5 SLC35H1 SLC71A2 SLC7A1 TMEM167B TMX2 VEZT ZFYVE27
Entrez ID		200894	22908
HPRD ID		12334	07587
Ensembl ID		ENSG00000169379	ENSG00000211456
Uniprot IDs		A0A7P0T892 A0A7P0T933 A0A7P0Z473 Q3SXY8	A0A5F9ZHN7 A0A9L9PXJ6 B4DVV3 E9PGZ4 Q9NTJ5
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding SNAP Receptor Activity SNARE Complex Assembly Plasma Membrane Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Establishment Of Protein Localization To Plasma Membrane Endomembrane System Chloride Channel Inhibitor Activity Sterol Biosynthetic Process Bleb Assembly Heme Oxidation Heme Oxygenase (decyclizing) Activity Structural Constituent Of Myelin Sheath Membrane Fusion Specific Granule Membrane Establishment Of Protein Localization To Membrane Vesicle Organization Membrane Organization Myelination Axon Ensheathment Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Heme Metabolic Process SNARE Binding Identical Protein Binding Transport Vesicle Golgi To Plasma Membrane Protein Transport Lipid Metabolic Process Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Porphyrin-containing Compound Metabolic Process Lipid Homeostasis Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Membrane Endoplasmic Reticulum Membrane COPI Vesicle Coat COPI-coated Vesicle Membrane Endoplasmic Reticulum Membrane Coat Intra-Golgi Vesicle-mediated Transport Bile Acid:sodium Symporter Activity Endoplasmic Reticulum Tubular Network Formation Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Endoplasmic Reticulum Organization Golgi Membrane Structural Molecule Activity Sodium Ion Transport Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
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