ARL13B and VAMP4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARL13B	VAMP4
Description		ARF like GTPase 13B	vesicle associated membrane protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Microtubule Cytoskeleton Membrane Motile Cilium Ciliary Basal Body Cell Projection Intercellular Bridge Ciliary Membrane Non-motile Cilium	Golgi Membrane Lysosome Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Transport Vesicle Endocytic Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane SNARE Complex Trans-Golgi Network Membrane Phagocytic Vesicle Bounding Membrane Of Organelle Presynaptic Endosome Membrane Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding	Protein Binding
	Biological Process	Heart Looping Smoothened Signaling Pathway Determination Of Left/right Symmetry Dorsal/ventral Pattern Formation Neural Tube Patterning Interneuron Migration From The Subpallium To The Cortex Formation Of Radial Glial Scaffolds Cilium Assembly Left/right Axis Specification Receptor Localization To Non-motile Cilium Non-motile Cilium Assembly	Synaptic Vesicle To Endosome Fusion Vesicle-mediated Transport Endocytic Recycling SNARE Complex Assembly Regulation Of Golgi To Plasma Membrane Protein Transport Golgi To Plasma Membrane Protein Transport Cellular Response To Type II Interferon Golgi Ribbon Formation Vesicle-mediated Transport To The Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Regulation Of Synaptic Vesicle Endocytosis
Pathways		ARL13B-mediated ciliary trafficking of INPP5E RHOQ GTPase cycle RHOJ GTPase cycle Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases		Joubert syndrome
GWAS			Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 25625606) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		146 interacting genes: ACSF2 AIG1 ALG3 ANKRD46 AOC3 AQP10 ARLN B4GALNT2 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C1GALT1 C2CD2L CCDC167 CCL4 CCL4L2 CD151 CD302 CD53 CDIPT CFHR5 CLDN4 CLDN8 CLEC4G CLEC7A CLN6 CMTM3 CMTM7 COL8A2 CSGALNACT2 CTSA CXCL16 CYB561D2 EBP EMP1 ENTPD3 ERG28 FAXDC2 FDFT1 FKBP8 FUNDC2 FXYD6 GAD2 GIMAP1 GIMAP5 GJB2 GOSR2 GPR37L1 HMOX1 HMOX2 HOMER3 ICMT IGFBP5 INSIG2 ITGAM JAGN1 KCNJ2 KLRG1 LEPROTL1 LHFPL5 LPAR3 MAL2 MALL MMD MOSPD3 MUCL1 MYADML2 NAT8 NINJ2 NKG7 NRM NUCB2 ORMDL1 ORMDL3 PAEP PDZK1IP1 PGAP2 PKNOX1 PLN PLP1 PLP2 PLPP4 PLPPR2 PMP22 PNLIPRP1 PRB1 PTPN9 RTP2 RUSF1 S100A2 SACM1L SEMA4G SLC13A3 SLC2A5 SLC35A1 SLC35B1 SLC38A7 SLC39A2 SMAGP SMCO4 SPN STRIT1 STX1A STX7 STX8 TECR TEX264 TFRC THSD7A THSD7B TM6SF2 TMEM11 TMEM120B TMEM121 TMEM128 TMEM14B TMEM14C TMEM187 TMEM190 TMEM218 TMEM229B TMEM254 TMEM43 TMEM54 TMEM60 TMEM65 TMEM79 TMEM86B TMEM97 TMUB2 TNFRSF10C TNMD TRARG1 TSPO2 UBE2I VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VSTM1 WFDC2 YIPF6 ZDHHC15	50 interacting genes: ANKS6 AP1M1 AQP6 ARL13B BCL2L13 BIK CD79A CFTR CISD2 CPLX4 CSNK2A1 CYB5R3 DNAJC5 EBP ELOVL4 ERGIC3 EVI2B FAM209A FAM210B GPR152 GPX8 HSD17B13 KASH5 LDLRAD1 LEUTX MFF MGST3 MTIF3 PACS1 PSCA PTGES REEP4 RETREG3 SAR1A SCN3B SEC11C SLC10A6 SLC35H1 SSMEM1 STOM STX16 STX1A STX4 STX6 SYT2 TM4SF19 TMEM205 TMEM51 TMX2 TRIM54
Entrez ID		200894	8674
HPRD ID		12334	06070
Ensembl ID		ENSG00000169379	ENSG00000117533
Uniprot IDs		A0A7P0T892 A0A7P0T933 A0A7P0Z473 Q3SXY8	O75379 Q6IAZ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum SNARE Complex Protein Binding SNAP Receptor Activity SNARE Complex Assembly Plasma Membrane Vesicle Fusion Organelle Fusion Organelle Membrane Fusion Establishment Of Protein Localization To Plasma Membrane Endomembrane System Chloride Channel Inhibitor Activity Sterol Biosynthetic Process Bleb Assembly Heme Oxidation Heme Oxygenase (decyclizing) Activity Structural Constituent Of Myelin Sheath Membrane Fusion Specific Granule Membrane Establishment Of Protein Localization To Membrane Vesicle Organization Membrane Organization Myelination Axon Ensheathment Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Heme Metabolic Process SNARE Binding Identical Protein Binding Transport Vesicle Golgi To Plasma Membrane Protein Transport Lipid Metabolic Process Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Porphyrin-containing Compound Metabolic Process Lipid Homeostasis Intracellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Membrane SNARE Binding SNARE Complex Vesicle Docking Endoplasmic Reticulum Membrane Organelle Localization By Membrane Tethering Endoplasmic Reticulum SNAP Receptor Activity Membrane Docking Glutathione Peroxidase Activity Synaptic Vesicle Membrane Protein Binding Steroid Biosynthetic Process Synaptic Vesicle Exocytosis Cholesterol Biosynthetic Process Chloride Channel Inhibitor Activity Unsaturated Fatty Acid Metabolic Process ATP-dependent Protein Binding Mitochondrial Membrane Vesicle Fusion Chromaffin Granule Membrane Sterol Biosynthetic Process Organelle Membrane Fusion Small Molecule Biosynthetic Process Vesicle Organization Mitochondrial Outer Membrane Syntaxin Binding Vesicle-mediated Transport SNARE Complex Assembly Organelle Fusion Intracellular Protein Transport Endomembrane System Membrane Fusion
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