DCP1B and EXOSC6

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
HPRD (two hybrid)

		DCP1B	EXOSC6
Gene Name		decapping mRNA 1B	exosome component 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Exosome (RNase Complex) Nucleolus Cytosol
	Molecular Function	RNA 7-methylguanosine Cap Binding MRNA Binding Protein Binding Hydrolase Activity Enzyme Regulator Activity	Exoribonuclease Activity Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Gene Expression Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Catalytic Activity	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Processing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Isotype Switching
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Regulation of mRNA stability by proteins that bind AU-rich elements KSRP destabilizes mRNA mRNA decay by 3' to 5' exoribonuclease ATF4 activates genes Tristetraprolin (TTP) destabilizes mRNA PERK regulates gene expression Unfolded Protein Response (UPR) Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Obesity-related traits ( 23251661) Response to gemcitabine in pancreatic cancer ( 22142827)
Protein-Protein Interactions		8 interactors: DCP2 EDC3 EXOSC6 LSM8 SMAD4 UPF2 XRN1 ZFP36	35 interactors: C1QBP CHPF DCP1B DIS3 DNAJC30 EIF3I ESRRA EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC7 EXOSC8 EXOSC9 GSE1 LSM1 LSM7 LSM8 MAN2C1 MIF4GD MOCS3 MPP6 MRPL4 MRPS18B NDUFA13 NUDT21 PSMB1 RAB3GAP2 SKIV2L2 SRSF3 TUFM UPF2 XRN1 ZFP36
Entrez ID		196513	118460
HPRD ID		13124	12107
Ensembl ID		ENSG00000151065	ENSG00000223496
Uniprot IDs		Q8IZD4	Q5RKV6
PDB IDs			2NN6
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nephrogenic Mesenchyme Morphogenesis RRNA Metabolic Process Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Cellular Metabolic Process Endocardial Cell Differentiation Nuclear MRNA Surveillance Formation Of Anatomical Boundary Negative Regulation Of Translation Involved In Gene Silencing By MiRNA DNA Deamination Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis RNA Surveillance Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation RRNA Catabolic Process Brainstem Development SMAD Protein Complex Assembly RNA Destabilization Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Regulation Of Hair Follicle Development Nucleic Acid Phosphodiester Bond Hydrolysis	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process RNA Catabolic Process RRNA Metabolic Process Aromatic Compound Catabolic Process Ribosome Biogenesis RRNA Processing Ribonucleoprotein Complex Biogenesis Gene Expression Cellular Macromolecule Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic NcRNA Metabolic Process Nuclear MRNA Surveillance RNA Metabolic Process RNA Surveillance RRNA Catabolic Process Maturation Of 5.8S RRNA RNA Phosphodiester Bond Hydrolysis Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Catabolic Process Nucleobase-containing Compound Metabolic Process Histone MRNA Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Processing Cellular Metabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process CUT Catabolic Process Histone MRNA Metabolic Process MRNA Processing RNA Splicing Metabolic Process RNA 3'-end Processing RNA Splicing, Via Transesterification Reactions RNA Localization DNA Deamination Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Intracellular MRNA Localization Mitochondrial Translational Elongation MRNA 3'-end Processing Mitochondrion Organization Mitochondrial Translation MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Tagcloud ?		atxn2 bid ccnf cdkn1a cntn4 dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 tprkb translocate upregulations wdfy1
Tagcloud (Difference) ?		atxn2 bid ccnf cdkn1a cntn4 dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 tprkb translocate upregulations wdfy1
Tagcloud (Intersection) ?