DCP1B and NSMAF

Number of citations: 110 (PubMedID 26133670)
Data Source: BioGRID (two hybrid, pull down)

		DCP1B	NSMAF
Name		decapping mRNA 1B	neutral sphingomyelinase activation associated factor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane	Cytoplasm Cytosol Membrane
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Ceramide Metabolic Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Amide Metabolic Process Positive Regulation Of Lipid Metabolic Process Regulation Of Membrane Lipid Metabolic Process
Pathways		mRNA decay by 5' to 3' exoribonuclease	TNFR1-mediated ceramide production
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Grapefruit juice consumption ( 31046077 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Response to gemcitabine in pancreatic cancer ( 22142827 ) Survival in pancreatic cancer ( 28470677 )	Basophil count ( 32888494 ) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269 ) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483 )
Interacting Genes		10 interacting genes: DCP2 EXOSC6 GSK3B LSM8 MIR15B NSMAF SMAD4 UPF2 XRN1 ZFP36	6 interacting genes: ACTB CD40 DCP1A DCP1B RACK1 TNFRSF1A
Entrez ID		196513	8439
HPRD ID		13124	09117
Ensembl ID		ENSG00000151065	ENSG00000035681
Uniprot IDs		B4DVJ6 Q8IZD4	Q92636
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Catabolic Process 5'-3' RNA Exonuclease Activity RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Negative Regulation Of Glycogen Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Nuclear MRNA Surveillance P-body Nucleic Acid Metabolic Process Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Catabolic Process Exosome (RNase Complex) Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase RNA Binding Telomerase RNA Binding Cardiac Muscle Hypertrophy Histone MRNA Metabolic Process Muscle Hypertrophy Regulation Of Glycogen Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Translation Nuclear RNA Surveillance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Telomere Maintenance Regulation Of Glycogen Metabolic Process RNA Surveillance Catabolic Process Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Microtubule Anchoring At Centrosome Regulation Of Metabolic Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Cardiac Myofibril Assembly	Enzyme Activator Activity Deadenylation-independent Decapping Of Nuclear-transcribed MRNA 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA MRNA Methylguanosine-cap Decapping RNA Decapping Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Kinesin Binding Positive Regulation Of DNA Recombination Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Cellular Response To Mechanical Stimulus Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Protein Localization To Plasma Membrane Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Development Positive Regulation Of Developmental Process Regulation Of Gene Expression Regulation Of Norepinephrine Uptake Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process IRE1-RACK1-PP2A Complex Negative Regulation Of Translational Frameshifting P-body Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Regulation Of DNA Recombination Regulation Of Macromolecule Metabolic Process Transporter Regulator Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Response To Cobalamin Regulation Of Protein Localization To Cell Periphery Regulation Of Transepithelial Transport Cellular Response To Erythropoietin Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Regulation Of Protein Localization To Membrane Protein Localization To Adherens Junction Regulation Of Metabolic Process Dense Body Regulation Of Protein Kinase C Signaling Response To Erythropoietin Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Translational Elongation