DCP1B and ZFP36

Number of citations: 45 (PubMedID 21964062)
Data Source: BioGRID (two hybrid, proximity labelling technology)

		DCP1B	ZFP36
Name		decapping mRNA 1B	ZFP36 ring finger protein
Structure		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane	Exosome (RNase Complex) P-body Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule CCR4-NOT Complex Ribonucleoprotein Complex
	Molecular Function	MRNA Binding Protein Binding Enzyme Activator Activity Hydrolase Activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] Hydrolase Activity	DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding Heat Shock Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein-containing Complex Binding Metal Ion Binding RNA Polymerase Binding 14-3-3 Protein Binding Protein-RNA Sequence-specific Adaptor Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Deadenylation-independent Decapping Of Nuclear-transcribed MRNA	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Response To Wounding Regulation Of Keratinocyte Proliferation Regulatory NcRNA-mediated Gene Silencing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription MiRNA-mediated Gene Silencing By Inhibition Of Translation P38MAPK Cascade Response To Starvation Regulation Of MRNA Stability Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Fat Cell Differentiation Regulation Of Keratinocyte Differentiation Negative Regulation Of Erythrocyte Differentiation MRNA Transport Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Glucocorticoid Stimulus Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Keratinocyte Apoptotic Process Negative Regulation Of Polynucleotide Adenylyltransferase Activity Positive Regulation Of Intracellular MRNA Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Positive Regulation Of MiRNA-mediated Gene Silencing
Pathways		mRNA decay by 5' to 3' exoribonuclease	Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885 ) Grapefruit juice consumption ( 31046077 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Response to gemcitabine in pancreatic cancer ( 22142827 ) Survival in pancreatic cancer ( 28470677 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: MX1
Interacting Genes		10 interacting genes: DCP2 EXOSC6 GSK3B LSM8 MIR15B NSMAF SMAD4 UPF2 XRN1 ZFP36	28 interacting genes: APP ATG16L1 CCDC85B CDK6 CXCL8 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 FHL3 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 PRMT2 RUNX1T1 SFN TNF UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		196513	7538
HPRD ID		13124	01835
Ensembl ID		ENSG00000151065	ENSG00000128016
Uniprot IDs		B4DVJ6 Q8IZD4	P26651
PDB IDs		Not available	4J8S
GO Terms Enriched among Interactors		Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Catabolic Process 5'-3' RNA Exonuclease Activity RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Macromolecule Catabolic Process Negative Regulation Of Glycogen Biosynthetic Process Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Nuclear MRNA Surveillance P-body Nucleic Acid Metabolic Process Histone MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Catabolic Process Exosome (RNase Complex) Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase RNA Binding Telomerase RNA Binding Cardiac Muscle Hypertrophy Histone MRNA Metabolic Process Muscle Hypertrophy Regulation Of Glycogen Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Translation Nuclear RNA Surveillance Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Telomere Maintenance Regulation Of Glycogen Metabolic Process RNA Surveillance Catabolic Process Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Microtubule Anchoring At Centrosome Regulation Of Metabolic Process Negative Regulation Of Cellular Component Organization Negative Regulation Of Cardiac Myofibril Assembly	Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear MRNA Surveillance Nuclear-transcribed MRNA Catabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding MRNA Catabolic Process Response To Cytokine RRNA Catabolic Process Response To Peptide Nucleus Response To External Biotic Stimulus Positive Regulation Of Leukocyte Migration Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Protein Kinase C Inhibitor Activity Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Gene Expression RNA Catabolic Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of Cell Differentiation Positive Regulation Of Immune System Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Immune System Process Negative Regulation Of DNA-templated Transcription Cytoplasm Nuclear RNA Surveillance Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Regulation Of Leukocyte Migration Positive Regulation Of Biosynthetic Process Cytosol Regulation Of Viral Life Cycle RNA Surveillance Phosphoserine Residue Binding Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Protein Sequestering Activity Regulation Of Translation