DCP1B and ZFP36

Number of citations of the paper that reports this interaction (PMID 21964062)
3

Data Source:
BioGRID (two hybrid)

		DCP1B	ZFP36
Gene Name		decapping mRNA 1B	ZFP36 ring finger protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Cytoplasm Cytosol Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule
	Molecular Function	RNA 7-methylguanosine Cap Binding MRNA Binding Protein Binding Hydrolase Activity Enzyme Regulator Activity	DNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding AU-rich Element Binding Enzyme Binding Protein Kinase Binding C-C Chemokine Binding MRNA 3'-UTR AU-rich Region Binding Poly(A) RNA Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Gene Expression Deadenylation-independent Decapping Of Nuclear-transcribed MRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Regulation Of Catalytic Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Gene Expression Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Intracellular Signal Transduction Response To Starvation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay	Regulation of mRNA stability by proteins that bind AU-rich elements Tristetraprolin (TTP) destabilizes mRNA
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Obesity-related traits ( 23251661) Response to gemcitabine in pancreatic cancer ( 22142827)
Protein-Protein Interactions		8 interactors: DCP2 EDC3 EXOSC6 LSM8 SMAD4 UPF2 XRN1 ZFP36	22 interactors: APP CCDC85B CDK6 DCP1B DHX36 DNAJB1 EDC3 EXOSC6 EXOSC8 HMGB1 HOXC9 MAPK1 MAPKAPK2 NCL NUP214 SFN UPF2 XRN1 YWHAB YWHAG YWHAH ZDHHC17
Entrez ID		196513	7538
HPRD ID		13124	01835
Ensembl ID		ENSG00000151065	ENSG00000128016
Uniprot IDs		Q8IZD4	M0QY76 P26651
PDB IDs			4J8S
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Histone MRNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Catabolic Process Nitrogen Compound Metabolic Process Histone MRNA Metabolic Process Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nephrogenic Mesenchyme Morphogenesis RRNA Metabolic Process Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Cellular Metabolic Process Endocardial Cell Differentiation Nuclear MRNA Surveillance Formation Of Anatomical Boundary Negative Regulation Of Translation Involved In Gene Silencing By MiRNA DNA Deamination Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis RNA Surveillance Endothelial Cell Activation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Valve Formation Sebaceous Gland Development 3'-UTR-mediated MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Somite Rostral/caudal Axis Specification Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation RRNA Catabolic Process Brainstem Development SMAD Protein Complex Assembly RNA Destabilization Regulation Of SMAD Protein Import Into Nucleus Atrioventricular Canal Development Regulation Of Hair Follicle Development Nucleic Acid Phosphodiester Bond Hydrolysis	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway MRNA Catabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway RNA Catabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Aromatic Compound Catabolic Process Gene Expression Positive Regulation Of Mitochondrion Organization MRNA Metabolic Process RNA Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Cellular Response To Heat Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Catabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process System Development Apoptotic Process Cellular Nitrogen Compound Metabolic Process Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Cell Death Death Cellular Metabolic Process Cellular Response To Heat Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Intracellular Transport Regulation Of Protein Kinase Activity Developmental Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Innate Immune Response Anatomical Structure Development Positive Regulation Of Signal Transduction Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Catabolic Process Regulation Of Organelle Organization Regulation Of Catalytic Activity Response To Heat Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death
Tagcloud ?		atxn2 bid ccnf cdkn1a cntn4 dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 tprkb translocate upregulations wdfy1	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3
Tagcloud (Difference) ?		atxn2 bid ccnf cdkn1a cntn4 dysregulations granule granules haploinsufficiency hnrnpa1 hnrnpa2b1 immunoblots inca1 mapt noteworthy nucleator plin4 pnpla2 prioritized smn tardbp tbc1d24 tia tia1 tial1 tprkb translocate upregulations wdfy1	annotation bub california cruz databases david deterioration downloaded exploring geo gse27567 h17 hub inheritance mendelian networks omim omnibus ranked santa topological visualization xpc xrcc4 xrcc5 ybx1 yy1 zfhx3 zmat3
Tagcloud (Intersection) ?