PSMA6 and PSMC6

Number of citations of the paper that reports this interaction (PubMedID 28292943)
74

Data Source:
BioGRID (pull down, biochemical)

		PSMA6	PSMC6
Description		proteasome 20S subunit alpha 6	proteasome 26S subunit, ATPase 6
Image
GO Annotations	Cellular Component	Proteasome Complex P-body Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Proteasome Core Complex Ribosome Cilium Nuclear Matrix Proteasome Core Complex, Alpha-subunit Complex Myofibril Sarcomere Extracellular Exosome	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Regulatory Particle, Base Subcomplex Membrane Inclusion Body Proteasome Accessory Complex Cytosolic Proteasome Complex Extracellular Exosome
	Molecular Function	RNA Binding Endopeptidase Activity Protein Binding Purine Ribonucleoside Triphosphate Binding NF-kappaB Binding	Nucleotide Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein-macromolecule Adaptor Activity Proteasome-activating Activity Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Inflammatory Response Proteolysis Involved In Protein Catabolic Process	ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling SARS-CoV-1 targets host intracellular signalling and regulatory pathways KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs		(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Creatine kinase levels ( 29403010) Psoriasis ( 20953189 25903422)	Prostate cancer ( 23535732)
Interacting Genes		34 interacting genes: ALKBH4 BRCA1 BRME1 C19orf47 CADM1 CEBPA ECT2 ERH HSPB1 KRTAP4-2 LIG4 LIMD2 NEDD8 PAXIP1 PLK1 POLR2L PSMA2 PSMA3 PSMA4 PSMA7 PSMC6 RNF170 RTP5 SIRPA SMCO3 TEPSIN TRIM39 TSPYL1 UBC UBD USP4 ZBTB44 ZKSCAN4 ZNF596	19 interacting genes: BYSL C1orf216 CCDC146 CCDC85B CCT2 CDC37 CDC42 CEBPA CRK CRKL CYB5R2 GTF2A1 PAAF1 PSMA6 PSMD9 SDCBP SEC14L5 SMARCE1 UBE2I
Entrez ID		5687	5706
HPRD ID		04171	04086
Ensembl ID		ENSG00000100902	ENSG00000100519
Uniprot IDs		A0A140VK44 P60900	A0A087X2I1 P62333
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSG 6MSH 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN	5GJQ 5GJR 5L4G 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHJ 5VHM 5VHN 5VHO 5VHP 5VHQ 5VHR 5VHS 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex, Alpha-subunit Complex Proteasome Complex Proteasome Core Complex Modification-dependent Protein Catabolic Process Nucleus Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Nucleoplasm Mitotic G2 DNA Damage Checkpoint Signaling Proteolysis Regulation Of Cell Cycle G2/M Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Mitotic G2/M Transition Checkpoint Cellular Response To Stress Response To Ionizing Radiation Protein Ubiquitination Macromolecule Catabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Protein Modification By Small Protein Conjugation Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Initiation Cellular Response To Lithium Ion Regulation Of Canonical NF-kappaB Signal Transduction Protein Tag Activity Proteasomal Protein Catabolic Process Transcription By RNA Polymerase I Midbody Response To Lithium Ion Regulation Of DNA-templated Transcription Initiation Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteolysis Double-strand Break Repair DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Recombination Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Response To Tumor Necrosis Factor Response To Stress Regulation Of Cell Cycle Phase Transition Identical Protein Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Negative Regulation Of Protein Kinase C Signaling Establishment Of Integrated Proviral Latency	Helper T Cell Diapedesis Cerebellar Neuron Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Diapedesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Endothelin Receptor Signaling Pathway Regulation Of Cell Growth Positive Regulation Of Receptor Clustering Reelin-mediated Signaling Pathway Postsynaptic Specialization Assembly Establishment Of Cell Polarity Regulation Of Receptor Clustering Positive Regulation Of Rac Protein Signal Transduction Kinase Binding Mononuclear Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Locomotion Regulation Of Growth Positive Regulation Of Cell Motility Positive Regulation Of Cell-substrate Adhesion Nuclear Matrix Postsynaptic Specialization Organization Cellular Component Assembly Regulation Of Rac Protein Signal Transduction Positive Regulation Of Cell Growth Establishment Or Maintenance Of Cell Polarity T Cell Migration Macrophage Differentiation Positive Regulation Of Intracellular Signal Transduction Protein-containing Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Phosphotyrosine Residue Binding Dendrite Development Positive Regulation Of Protein Localization Central Nervous System Neuron Development Purine Ribonucleoside Triphosphate Binding Interleukin-5 Receptor Complex SUMO Conjugating Enzyme Activity Regulation Of Cell Adhesion Mediated By Integrin Regulation Of T Cell Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Adhesion Positive Regulation Of Cell Communication Leukocyte Migration Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Signaling GBD Domain Binding
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