ECHS1 and LRRK1

Number of citations: 77 (PubMedID 29513927)
Data Source: BioGRID (pull down)

		ECHS1	LRRK1
Name		enoyl-CoA hydratase, short chain 1	leucine rich repeat kinase 1
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane
	Molecular Function	Catalytic Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Lyase Activity Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity 3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Identical Protein Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process	Positive Regulation Of Signal Transduction Intracellular Signal Transduction Osteoclast Development Bone Resorption Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways		Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA Mitochondrial short-chain enoyl-CoA hydratase deficiency 1	None
Drugs		Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)cinnamoyl-CoA Omega-3-carboxylic acids	None
GWAS		Lifespan ( 25918517 ) Nonunion in individuals with fractures ( 30680360 ) Serum metabolite levels ( 33031748 )	Central corneal thickness ( 28171582 29760442 31798171 32528159 ) Corneal structure ( 23291589 ) Height ( 28552196 ) Systemic lupus erythematosus ( 33272962 )
Novel Interactors		None recorded	2 novel interactors: SELENOS TM2D3
Interacting Genes		16 interacting genes: CAPN1 CDC42 CLDN12 CYP2E1 ERCC6 FXR1 FXR2 GRB2 KAT2A LRRK1 LRRK2 PPM1B SERPINA1 SIRT3 UBA1 ZNG1B	53 interacting genes: ABL1 BAG1 BAG2 BAG3 BAG5 BLOC1S5 C11orf52 CBLB CCL21 CD2BP2 CDC42EP3 CDK1 CDK5RAP2 CHGB CIMIP4 CKAP2 CLVS1 CPLX3 CWC15 ECHS1 EGFR ENKUR EPHA8 FAM184A FBXL14 FGFR2 FLT4 FOXP1 GAK GNAZ GPBP1L1 ITCH KIF20A MATK MTG1 NEK1 NUDT16L1 ODF2 PAK6 PDCD4 PLK1 POLR2M RAB29 RET SCEL SH2D2A SNX21 SNX9 STUB1 TCF25 TEC TIRAP VGLL4
Entrez ID		1892	79705
HPRD ID		03799	14319
Ensembl ID		ENSG00000127884	ENSG00000154237
Uniprot IDs		P30084	Q38SD2
PDB IDs		2HW5	8E04 8E05 8E06 8FAC
GO Terms Enriched among Interactors		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intracellular Distribution Of Mitochondria Positive Regulation Of Long-term Neuronal Synaptic Plasticity Postsynapse Cytoplasmic Ribonucleoprotein Granule Mitochondrion Distribution Positive Regulation Of Canonical Wnt Signaling Pathway Translation Regulator Activity Neuron Projection Regulation Of Reactive Oxygen Species Metabolic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity GTP Binding Positive Regulation Of Wnt Signaling Pathway Identical Protein Binding Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Benzene Metabolic Process Regulation Of Defense Response Regulation Of Synaptic Plasticity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Modulation Of Chemical Synaptic Transmission Peptide Glutaryltransferase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Mitochondrion Localization Regulation Of Cell Communication Small GTPase-mediated Signal Transduction Regulation Of Intracellular Signal Transduction GBD Domain Binding Storage Vacuole Regulation Of Signaling Regulation Of Defense Response To Virus JNK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Histone H3K9 Acetyltransferase Activity Grb2-EGFR Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuronal Synaptic Plasticity	Protein Tyrosine Kinase Activity Protein Kinase Activity Kinase Activity Adenyl-nucleotide Exchange Factor Activity Regulation Of Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Post-translational Protein Modification Negative Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process Regulation Of Protein Ubiquitination Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Catabolic Process Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Nucleotide Binding Protein-folding Chaperone Binding Positive Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Golgi Organization Regulation Of Programmed Cell Death Positive Regulation Of Protein-containing Complex Assembly Regulation Of Protein Metabolic Process Regulation Of Protein-containing Complex Assembly T Cell Anergy Mitotic Cytokinesis Regulation Of Heart Growth Transferase Activity ATP Binding T Cell Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of JNK Cascade Protein Phosphorylation Positive Regulation Of T Cell Anergy T Cell Tolerance Induction Protein Folding Chaperone Complex Positive Regulation Of Protein Polymerization Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Phosphorylation Cytoskeleton-dependent Cytokinesis Chaperone-mediated Autophagy Regulation Of Organ Growth Regulation Of Signal Transduction Regulation Of T Cell Anergy