ECHS1 and CLDN12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ECHS1	CLDN12
Description		enoyl-CoA hydratase, short chain 1	claudin 12
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Plasma Membrane Bicellular Tight Junction Membrane Lateral Plasma Membrane Tight Junction Anchoring Junction Cell Periphery
	Molecular Function	Catalytic Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity Enoyl-CoA Hydratase Activity Protein Binding Lyase Activity Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity 3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity	Protein Binding Identical Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Maintenance Of Blood-brain Barrier Tight Junction Assembly
Pathways		Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA Mitochondrial short-chain enoyl-CoA hydratase deficiency 1	Tight junction interactions
Drugs		Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)cinnamoyl-CoA Omega-3-carboxylic acids
Diseases
GWAS		Lifespan ( 25918517) Nonunion in individuals with fractures ( 30680360) Serum metabolite levels ( 33031748)
Interacting Genes		16 interacting genes: CAPN1 CDC42 CLDN12 CYP2E1 ERCC6 FXR1 FXR2 GRB2 KAT2A LRRK1 LRRK2 PPM1B SERPINA1 SIRT3 UBA1 ZNG1B	4 interacting genes: ECHS1 SEC13 STRN4 TRARG1
Entrez ID		1892	9069
HPRD ID		03799	13064
Ensembl ID		ENSG00000127884	ENSG00000157224
Uniprot IDs		P30084	B2R687 P56749
PDB IDs		2HW5
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Intracellular Distribution Of Mitochondria Positive Regulation Of Long-term Neuronal Synaptic Plasticity Postsynapse Cytoplasmic Ribonucleoprotein Granule Mitochondrion Distribution Positive Regulation Of Canonical Wnt Signaling Pathway Translation Regulator Activity Neuron Projection Regulation Of Reactive Oxygen Species Metabolic Process Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity GTP Binding Positive Regulation Of Wnt Signaling Pathway Identical Protein Binding Carbon Tetrachloride Metabolic Process Halogenated Hydrocarbon Metabolic Process 4-nitrophenol Metabolic Process 4-nitrophenol 2-monooxygenase Activity Benzene Metabolic Process Regulation Of Defense Response Regulation Of Synaptic Plasticity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Modulation Of Chemical Synaptic Transmission Peptide Glutaryltransferase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Catalase Activity Positive Regulation Of Superoxide Dismutase Activity Cellular Response To Curcumin Caveola Neck GTP-dependent Protein Kinase Activity Wnt Signalosome Assembly Mitochondrion Localization Regulation Of Cell Communication Small GTPase-mediated Signal Transduction Regulation Of Intracellular Signal Transduction GBD Domain Binding Storage Vacuole Regulation Of Signaling Regulation Of Defense Response To Virus JNK Cascade Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Histone H3K9 Acetyltransferase Activity Grb2-EGFR Complex Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuronal Synaptic Plasticity	3-hydroxypropionyl-CoA Dehydratase Activity Crotonyl-CoA Hydratase Activity Enoyl-CoA Hydratase Activity Delta(3)-delta(2)-enoyl-CoA Isomerase Activity 3-hydroxyacyl-CoA Dehydratase Activity Vesicle Organization Nuclear Pore Outer Ring COPII-coated Vesicle Budding GATOR2 Complex Armadillo Repeat Domain Binding Glucose Import In Response To Insulin Stimulus Vesicle Fusion To Plasma Membrane Branched-chain Amino Acid Catabolic Process COPII-coated Vesicle Cargo Loading COPII Vesicle Coat Regulation Of Modification Of Synaptic Structure FAR/SIN/STRIPAK Complex Regulation Of Modification Of Postsynaptic Structure Endosome To Plasma Membrane Protein Transport D-glucose Import Branched-chain Amino Acid Metabolic Process Intracellular Protein Transport Negative Regulation Of Hippo Signaling Membrane Organization Protein Exit From Endoplasmic Reticulum Vesicle Budding From Membrane Vesicle Cargo Loading Protein Phosphatase 2A Binding D-glucose Transmembrane Transport Hexose Transmembrane Transport
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