ECHS1 and CYP2E1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ECHS1	CYP2E1
Gene Name		enoyl CoA hydratase, short chain, 1, mitochondrial	cytochrome P450, family 2, subfamily E, polypeptide 1
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Enoyl-CoA Hydratase Activity Protein Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding
	Biological Process	Fatty Acid Beta-oxidation Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Response To Ethanol Heterocycle Metabolic Process Oxidation-reduction Process
Pathways		Fatty acid, triacylglycerol, and ketone body metabolism Beta oxidation of octanoyl-CoA to hexanoyl-CoA Metabolism of lipids and lipoproteins Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Mitochondrial Fatty Acid Beta-Oxidation Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA mitochondrial fatty acid beta-oxidation of saturated fatty acids Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		8 interactors: CAPN1 CBWD2 CLDN12 CYP2E1 GRB2 PPM1B SERPINA1 UBA1	15 interactors: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1
Entrez ID		1892	1571
HPRD ID		03799	11813
Ensembl ID		ENSG00000127884	ENSG00000130649
Uniprot IDs		P30084	P05181
PDB IDs		2HW5	3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?		Receptor Metabolic Process Response To Methanol	Response To Misfolded Protein Reverse Cholesterol Transport Regulation Of Hormone Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Catabolic Process Organic Acid Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Cellular Organofluorine Metabolic Process L-alanine Catabolic Process, By Transamination Negative Regulation Of Formation Of Translation Preinitiation Complex Nitrate Catabolic Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Nitric Oxide Catabolic Process Regulation Of Neuronal Signal Transduction Sterol Transport Cholesterol Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Fatty Acid Oxidation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Lipid Oxidation Positive Regulation Of Proteasomal Protein Catabolic Process Creatine Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Positive Regulation Of Neurofibrillary Tangle Assembly Glycine Biosynthetic Process, By Transamination Of Glyoxylate Positive Regulation Of Reactive Oxygen Species Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Steroid Metabolic Process Cellular Response To Unfolded Protein Glyoxylate Catabolic Process Nitrate Metabolic Process Glial Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Stimulus L-alanine Metabolic Process L-alanine Catabolic Process Central Nervous System Myelin Maintenance Single-organism Behavior Response To Organic Substance Regulation Of Tau-protein Kinase Activity Response To Unfolded Protein Cellular Amino Acid Biosynthetic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling	afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified
Tagcloud (Difference) ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa sorbs1 ufa underling unraveling	afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified
Tagcloud (Intersection) ?