CALCA and BBS4

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		CALCA	BBS4
Gene Name		calcitonin-related polypeptide alpha	Bardet-Biedl syndrome 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton	Pericentriolar Material Centrosome Centriole Cytosol Cilium Nonmotile Primary Cilium Motile Cilium Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Protein Complex Binding Identical Protein Binding	RNA Polymerase II Repressing Transcription Factor Binding Microtubule Motor Activity Protein Binding Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Endothelial Cell Proliferation Vasculature Development Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Rate G-protein Coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Embryo Implantation Aging Feeding Behavior Regulation Of Blood Pressure Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Ossification Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Negative Regulation Of Neurological System Process Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Negative Regulation Of Smooth Muscle Contraction Response To Pain Regulation Of Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cytosolic Calcium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neural Tube Closure Retina Homeostasis Heart Looping Negative Regulation Of Systemic Arterial Blood Pressure Organelle Organization Spermatid Development Visual Perception Sensory Perception Of Smell Metabolic Process Negative Regulation Of Gene Expression Protein Transport Dendrite Development Regulation Of Lipid Metabolic Process Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Regulation Of Cytokinesis Protein Localization To Organelle Microtubule Anchoring At Centrosome Nonmotile Primary Cilium Assembly Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Cilium Assembly Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Intracellular Transport Brain Morphogenesis Sensory Processing Centrosome Organization Maintenance Of Protein Location In Nucleus Cilium Morphogenesis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Protein Localization To Centrosome
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Amyloids Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors) Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BBS1 BBS4 CALCRL ECE1 NRD1 RAMP1 RAMP2	14 interactors: ACTB BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 MYOG PAX2 PCM1
Entrez ID		796	585
HPRD ID		00238	08982
Ensembl ID		ENSG00000110680	ENSG00000140463
Uniprot IDs		P01258 P06881	Q96RK4
PDB IDs		1LS7 2JXZ
Enriched GO Terms of Interacting Partners?		Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Cardiovascular System Development Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Development Anatomical Structure Morphogenesis Protein Localization To Plasma Membrane Nonmotile Primary Cilium Assembly Regulation Of Blood Pressure Protein Transport Establishment Of Protein Localization CAMP Biosynthetic Process Plasma Membrane Organization Photoreceptor Cell Maintenance CAMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Protein Localization Blood Circulation Calcium Ion Transport Angiogenesis Cyclic Nucleotide Biosynthetic Process Receptor-mediated Endocytosis Protein Localization To Membrane Retina Homeostasis Blood Vessel Morphogenesis Endomembrane System Organization Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Calcitonin Catabolic Process Substance P Catabolic Process Endothelin Maturation Cellular Response To Sucrose Stimulus Cellular Protein Localization Blood Vessel Development Regulation Of Systemic Arterial Blood Pressure Vasculature Development Vesicle-mediated Transport Anatomical Structure Development Intracellular Transport Neuropeptide Catabolic Process Endocytosis Positive Regulation Of Cilium Assembly Sensory Processing Basement Membrane Assembly Developmental Process	Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Response To Organic Substance Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Cell Fate Commitment Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Positive Regulation Of Muscle Atrophy Golgi To Plasma Membrane CFTR Protein Transport Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Negative Regulation Of Cell Differentiation Stem Cell Differentiation Regulation Of Heart Rate Vesicle-mediated Transport Organelle Organization Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Cellular Metabolic Process Cellular Protein Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Organelle Localization Cellular Response To Tumor Necrosis Factor Amino-acid Betaine Catabolic Process Regulation Of Homocysteine Metabolic Process Negative Regulation Of Cytolysis Kidney Rudiment Formation Positive Regulation Of Cellular Metabolic Process G2/M Transition Of Mitotic Cell Cycle Paramesonephric Duct Development Vestibulocochlear Nerve Formation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Regulation Of Kidney Size Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process
Tagcloud ?		11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity	129p3 6byj acat1 adip5 adipose adpgk crabp1 csk cyp19a1 depot depots dpp8 fatness gonadal hexa il18 intercross linkage lipc lod lsm16 man2c1 mpi1 neil1 qtl retroperitoneal rs30280752 summed thsd4
Tagcloud (Difference) ?		11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity	129p3 6byj acat1 adip5 adipose adpgk crabp1 csk cyp19a1 depot depots dpp8 fatness gonadal hexa il18 intercross linkage lipc lod lsm16 man2c1 mpi1 neil1 qtl retroperitoneal rs30280752 summed thsd4
Tagcloud (Intersection) ?