CALCA and BBS1

Number of citations of the paper that reports this interaction (PubMedID 18000879)
0

Data Source:
BioGRID (two hybrid)

		CALCA	BBS1
Description		calcitonin related polypeptide alpha	Bardet-Biedl syndrome 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle	Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Cilium Axoneme Membrane Motile Cilium Centriolar Satellite BBSome Cell Projection Ciliary Membrane
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding Protein-containing Complex Binding Receptor Ligand Activity	Signaling Receptor Binding Patched Binding Smoothened Binding Protein Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Response To Yeast Endothelial Cell Proliferation Vasculature Development Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Embryo Implantation Regulation Of Blood Pressure Negative Regulation Of Calcium Ion Transport Into Cytosol Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Vasodilation Endothelial Cell Migration Innate Immune Response Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Contraction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Tumor Necrosis Factor Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway	Microtubule Cytoskeleton Organization Neuron Migration Retina Homeostasis Lipid Metabolic Process Visual Perception Sensory Perception Of Smell Intracellular Protein Localization Photoreceptor Cell Morphogenesis Fertilization Protein Transport Dendrite Development Ventricular System Development Striatum Development Hippocampus Development Cerebral Cortex Development Cell Projection Organization Adult Behavior Response To Endoplasmic Reticulum Stress Olfactory Behavior Hormone Metabolic Process Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Retina Development In Camera-type Eye Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Neural Precursor Cell Proliferation Protein Localization To Cilium Non-motile Cilium Assembly
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors	BBSome-mediated cargo-targeting to cilium
Drugs		Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)	Bipolar disorder ( 21926972) Height ( 28552196)
Interacting Genes		8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2	13 interacting genes: BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 PARK7 PAX2 TSPAN7
Entrez ID		796	582
HPRD ID		00238	01950
Ensembl ID		ENSG00000110680	ENSG00000174483
Uniprot IDs		P01258 P06881	Q8NFJ9
PDB IDs		2JXZ 6E3Y 7KNU 7TYH 7TYO 9AUC	6XT9
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Amylin Receptor Signaling Pathway BBSome Receptor Internalization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Striatum Development Regulation Of Cilium Beat Frequency Retina Homeostasis Brain Morphogenesis Ventricular System Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Face Development Regulation Of Blood Pressure Receptor-mediated Endocytosis Protein Localization To Plasma Membrane Establishment Of Protein Localization Regulation Of Cilium Movement Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Photoreceptor Cell Maintenance Calcium Ion Transport Dendrite Development Heart Development Non-motile Cilium Assembly Regulation Of Microtubule-based Movement G Protein-coupled Receptor Signaling Pathway Ciliary Membrane Protein Localization To Membrane Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Coreceptor Activity Protein Localization To Cilium Endothelin Maturation Calcitonin Catabolic Process Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Binding Hippocampus Development Intracellular Protein Localization Sensory Perception Of Smell Cerebral Cortex Development Metalloendopeptidase Activity Endocytosis	Regulation Of Mitochondrial Membrane Potential Chemical Homeostasis Homeostatic Process Cellular Homeostasis Regulation Of Programmed Cell Death Regulation Of Aerobic Respiration Cytoplasm Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Regulation Of Cellular Respiration Cytosol Epithelial Cell Proliferation Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Mitochondrion Organization Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Autophagy Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Protein Metabolic Process Intracellular Chemical Homeostasis Regulation Of Calcium Ion Transport Into Cytosol Blood Vessel Remodeling Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process Axon Nucleus Localization Nuclear Migration Centriolar Satellite Microtubule Organizing Center Negative Regulation Of Reactive Oxygen Species Metabolic Process Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Proline Dipeptidase Activity Eye Pigmentation Glyoxal Catabolic Process L-dopa Decarboxylase Activator Activity Guanine Deglycation Protein Deglycase Activity Glyoxalase (glycolic Acid-forming) Activity Glycolate Biosynthetic Process Guanine Deglycation, Methylglyoxal Removal Guanine Deglycation, Glyoxal Removal Detoxification Of Mercury Ion Negative Regulation Of Death-inducing Signaling Complex Assembly Cellular Response To Glyoxal Glyoxal Metabolic Process Positive Regulation Of L-dopa Biosynthetic Process Tyrosine 3-monooxygenase Activator Activity
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