CALCA and RAMP2

Number of citations of the paper that reports this interaction (PMID 16531504)
6

Data Source:
HPRD (in vitro)

		CALCA	RAMP2
Gene Name		calcitonin-related polypeptide alpha	receptor (G protein-coupled) activity modifying protein 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Cell Surface Receptor Complex
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Protein Complex Binding Identical Protein Binding	Protein Binding Protein Transporter Activity Coreceptor Activity
	Biological Process	Endothelial Cell Proliferation Vasculature Development Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Heart Rate G-protein Coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Inflammatory Response Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Embryo Implantation Aging Feeding Behavior Regulation Of Blood Pressure Response To Heat Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Ossification Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Negative Regulation Of Neurological System Process Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Endothelial Cell Migration Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Blood Pressure Positive Regulation Of Ossification Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Negative Regulation Of Smooth Muscle Contraction Response To Pain Regulation Of Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cytosolic Calcium Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Intracellular Protein Transport G-protein Coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Development Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Amyloids Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors) Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Pramlintide
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BBS1 BBS4 CALCRL ECE1 NRD1 RAMP1 RAMP2	5 interactors: CALCA CALCRL IAPP SLC31A2 VIPR1
Entrez ID		796	10266
HPRD ID		00238	05516
Ensembl ID		ENSG00000110680	ENSG00000131477
Uniprot IDs		P01258 P06881	K7EMD3 O60895
PDB IDs		1LS7 2JXZ	2XVT 3AQE 3AQF
Enriched GO Terms of Interacting Partners?		Receptor Internalization Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Cardiovascular System Development Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Anatomical Structure Formation Involved In Morphogenesis Heart Development Anatomical Structure Morphogenesis Protein Localization To Plasma Membrane Nonmotile Primary Cilium Assembly Regulation Of Blood Pressure Protein Transport Establishment Of Protein Localization CAMP Biosynthetic Process Plasma Membrane Organization Photoreceptor Cell Maintenance CAMP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Protein Localization Blood Circulation Calcium Ion Transport Angiogenesis Cyclic Nucleotide Biosynthetic Process Receptor-mediated Endocytosis Protein Localization To Membrane Retina Homeostasis Blood Vessel Morphogenesis Endomembrane System Organization Cyclic Nucleotide Metabolic Process Positive Regulation Of Cellular Metabolic Process Calcitonin Catabolic Process Substance P Catabolic Process Endothelin Maturation Cellular Response To Sucrose Stimulus Cellular Protein Localization Blood Vessel Development Regulation Of Systemic Arterial Blood Pressure Vasculature Development Vesicle-mediated Transport Anatomical Structure Development Intracellular Transport Neuropeptide Catabolic Process Endocytosis Positive Regulation Of Cilium Assembly Sensory Processing Basement Membrane Assembly Developmental Process	Negative Regulation Of Bone Resorption G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Negative Regulation Of Bone Remodeling Negative Regulation Of Tissue Remodeling Regulation Of Bone Resorption Receptor Internalization Regulation Of Bone Remodeling Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Regulation Of Tissue Remodeling Positive Regulation Of CAMP Metabolic Process Receptor Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Sensory Perception Of Pain Feeding Behavior Regulation Of CAMP Metabolic Process Regulation Of Copper Ion Transmembrane Transport Cellular Response To Sucrose Stimulus Vasodilation Of Artery Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Muscle Contraction Cell-cell Signaling G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Interleukin-1 Alpha Production Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Regulation Of Inflammatory Response Negative Regulation Of Calcium Ion Transport Into Cytosol Receptor-mediated Endocytosis Positive Regulation Of Macrophage Differentiation Copper Ion Transmembrane Transport G-protein Coupled Receptor Internalization Cellular Metal Ion Homeostasis Negative Regulation Of Neurological System Process Monocyte Chemotaxis Negative Regulation Of Smooth Muscle Contraction Cellular Cation Homeostasis Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Cellular Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Response To Sucrose Endothelial Cell Proliferation Metal Ion Homeostasis Cellular Copper Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Muscle Contraction CAMP Biosynthetic Process Copper Ion Homeostasis Cellular Chemical Homeostasis
Tagcloud ?		11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity	abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Difference) ?		11p 11p15 allelic anaplastic constitutional differentiated federation figo gynecology heterozygosity homozygosity hras1 informative ins leukocytes loh losses marks obstetrics ovarian p20 pej6 pem36 phins310 polymorphic pth sense spanning tumorigenicity	abundantly accessory adrenomedullin bioactivities calcitonin ccaat clr evokes exerting glomeruli glut2 illustrating lethality littermates pathophysiological perk ramps reproduce rptecs streptozotocin stz subisoforms takes tubular tubule tubules tun tunicamycin
Tagcloud (Intersection) ?