CALCA and RAMP2

Number of citations of the paper that reports this interaction (PubMedID 16531504)
0

Data Source:
HPRD (in vitro)

		CALCA	RAMP2
Description		calcitonin related polypeptide alpha	receptor activity modifying protein 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Axon Neuronal Cell Body Hippocampal Mossy Fiber To CA3 Synapse Neuronal Dense Core Vesicle	Cytoplasm Lysosome Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Receptor Complex Adrenomedullin Receptor Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding Protein-containing Complex Binding Receptor Ligand Activity	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Adrenomedullin Binding
	Biological Process	Response To Yeast Endothelial Cell Proliferation Vasculature Development Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure G Protein-coupled Receptor Internalization Monocyte Chemotaxis Protein Phosphorylation Leukocyte Cell-cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Embryo Implantation Regulation Of Blood Pressure Negative Regulation Of Calcium Ion Transport Into Cytosol Antibacterial Humoral Response Antifungal Humoral Response Receptor Internalization Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-8 Production Vasodilation Endothelial Cell Migration Innate Immune Response Positive Regulation Of Macrophage Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Blood Pressure Negative Regulation Of Bone Resorption Negative Regulation Of DNA-templated Transcription Negative Regulation Of Smooth Muscle Contraction Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Regulation Of Cytosolic Calcium Ion Concentration Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Tumor Necrosis Factor Calcitonin Family Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway	Angiogenesis Vasculogenesis Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor 2 Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors	G alpha (s) signalling events Calcitonin-like ligand receptors High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab	Pramlintide
Diseases
GWAS		Diverticular disease ( 30177863) Hip circumference adjusted for BMI ( 34021172) Vitamin D levels ( 25208829)	A body shape index ( 34021172) Pulse pressure ( 30224653) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2	7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1
Entrez ID		796	10266
HPRD ID		00238	05516
Ensembl ID		ENSG00000110680	ENSG00000131477
Uniprot IDs		P01258 P06881	O60895
PDB IDs		2JXZ 6E3Y 7KNU 7TYH 7TYO 9AUC	2XVT 3AQE 3AQF 4RWF 6UUN 6V2E 7TYH 7TYX 7TYY
Enriched GO Terms of Interacting Partners?		Calcitonin Family Receptor Signaling Pathway Adrenomedullin Binding CGRP Receptor Complex Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Amylin Receptor Signaling Pathway BBSome Receptor Internalization Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Striatum Development Regulation Of Cilium Beat Frequency Retina Homeostasis Brain Morphogenesis Ventricular System Development Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Face Development Regulation Of Blood Pressure Receptor-mediated Endocytosis Protein Localization To Plasma Membrane Establishment Of Protein Localization Regulation Of Cilium Movement Protein Localization To Cell Periphery Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Photoreceptor Cell Maintenance Calcium Ion Transport Dendrite Development Heart Development Non-motile Cilium Assembly Regulation Of Microtubule-based Movement G Protein-coupled Receptor Signaling Pathway Ciliary Membrane Protein Localization To Membrane Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Coreceptor Activity Protein Localization To Cilium Endothelin Maturation Calcitonin Catabolic Process Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Binding Hippocampus Development Intracellular Protein Localization Sensory Perception Of Smell Cerebral Cortex Development Metalloendopeptidase Activity Endocytosis	Calcitonin Family Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Amylin Receptor 1 Signaling Pathway Amylin Receptor 2 Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway Amylin Receptor Signaling Pathway Negative Regulation Of Bone Resorption Negative Regulation Of Bone Remodeling Negative Regulation Of Osteoclast Differentiation Regulation Of Bone Resorption Response To Nerve Growth Factor G Protein-coupled Receptor Signaling Pathway Regulation Of Bone Remodeling Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Nerve Growth Factor Stimulus Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Myeloid Leukocyte Differentiation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Metal Ion Transport Receptor Internalization Regulation Of Osteoclast Differentiation Regulation Of Copper Ion Transmembrane Transport Positive Regulation Of Hippocampal Neuron Apoptotic Process Cellular Response To Sucrose Stimulus Regulation Of Tissue Remodeling Regulation Of Monoatomic Ion Transport Calcitonin Receptor Binding Cellular Response To Tumor Necrosis Factor Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Adrenomedullin Binding CGRP Receptor Complex Calcitonin Receptor Activity Hormone Activity Negative Regulation Of Hemopoiesis Positive Regulation Of Apoptotic Process Regulation Of Myeloid Leukocyte Differentiation Receptor Ligand Activity Response To Tumor Necrosis Factor Positive Regulation Of Programmed Cell Death Amylin Receptor 3 Signaling Pathway Siderophore Transport Vasoactive Intestinal Polypeptide Receptor Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Activity Adrenomedullin Receptor Complex Adrenomedullin Receptor Activity
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