E4F1 and RASSF1

Number of citations of the paper that reports this interaction (PubMedID 14729613)
0

Data Source:
BioGRID (genetic interference, pull down)
HPRD (in vivo, two hybrid, in vitro)

		E4F1	RASSF1
Description		E4F transcription factor 1	Ras association domain family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Nuclear Body	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Microtubule Cytoskeleton
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity CAMP Response Element Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Cycle Process Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Cell Division Regulation Of Cell Cycle	DNA Damage Response Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Protein Ubiquitination Protein Stabilization Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition
Pathways
Drugs
Diseases			Nasopharyngeal cancer Non-small cell lung cancer Bladder cancer
GWAS		Appendicular lean mass ( 33097823)	Basophil percentage of white cells ( 32888494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) High light scatter reticulocyte count ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 28991256 30285260) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		16 interacting genes: ANP32A ATM ATR CDKN2A EHMT2 HMGA2 KRTAP10-4 KRTAP10-7 PARP1 PRKDC RASSF1 RB1 SMAD9 SMARCA4 TP53 UPF2	68 interacting genes: AKT1 ARAF ATM ATP2B4 ATR ATRX AURKA AURKB BRAF C7orf25 C8orf33 CCND2 CCNE1 CDC20 CDK4 CDK6 CDKN2A CDKN2B CLNK CNKSR1 DAXX DDB1 E4F1 EPHA2 ERBB2 EXOSC8 FGFR4 FZR1 GLIS2 GRM1 HRAS IGFBP5 KAT2A KCNE3 KDELR2 KDM1A LATS2 MAP1B MAP1S MAP2K3 MAP2K6 MAPK8 MDM2 MET MOAP1 MST1 MYC NF2 NUDT10 PRKDC RAF1 RASSF5 RELA RHOA RHOU SMARCA4 STK11 STK4 SUV39H1 SUV39H2 TEAD2 TERT TNFRSF10A TNFRSF1A TSC1 TUBB TUBG1 XPA
Entrez ID		1877	11186
HPRD ID		04317	05470
Ensembl ID		ENSG00000167967	ENSG00000068028
Uniprot IDs		H3BSL4 H3BUJ7 Q66K89	Q9NS23
PDB IDs			2KZU
Enriched GO Terms of Interacting Partners?		Chromosome Organization Replicative Senescence Histone H2AXS139 Kinase Activity Response To Gamma Radiation Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Chromosome Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA Repair Regulation Of Chromosome Organization Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle P53 Binding Intracellular Signal Transduction Protein Localization To Organelle Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Ras Protein Signal Transduction Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Double-strand Break Repair Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Disordered Domain Specific Binding Telomere Maintenance	Regulation Of Cell Cycle Intracellular Signal Transduction Protein Kinase Activity Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Cycle Phase Transition Protein Serine Kinase Activity Response To UV Regulation Of Signal Transduction By P53 Class Mediator Signal Transduction Regulation Of Mitotic Cell Cycle Response To Radiation Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Programmed Cell Death Cellular Response To UV Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Component Organization Regulation Of Apoptotic Process Programmed Cell Death Nucleotide Binding Cell Death Cellular Response To Light Stimulus Regulation Of Protein Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Response To Light Stimulus Apoptotic Process Apoptotic Signaling Pathway Cell Cycle Phase Transition Cellular Response To Stress Positive Regulation Of Cellular Component Organization Regulation Of Catalytic Activity ATP Binding Negative Regulation Of Signal Transduction Transferase Activity Regulation Of Protein Phosphorylation Mitotic Cell Cycle Phase Transition
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