E4F1 and HMGA2

Number of citations of the paper that reports this interaction (PMID 14645522)
20

Data Source:
BioGRID (far western blotting)

		E4F1	HMGA2
Gene Name		E4F transcription factor 1	high mobility group AT-hook 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Spindle	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Ligase Activity CAMP Response Element Binding Metal Ion Binding	Regulatory Region DNA Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding AT DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity DNA-dependent Protein Kinase Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Replication Transcription, DNA-templated Mitotic Nuclear Division Cell Proliferation Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Cycle Process Viral Process Protein Ubiquitination Regulation Of Growth Cell Division Mitotic Cell Cycle Arrest	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process, Endonucleolytic Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Mitotic Nuclear Division Mitotic G2 DNA Damage Checkpoint Multicellular Organismal Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Histone H2A-S139 Phosphorylation Senescence-associated Heterochromatin Focus Assembly Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Positive Regulation Of Cell Cycle Arrest Oncogene-induced Cell Senescence Regulation Of Stem Cell Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cellular Response To X-ray Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug
Pathways			DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence
Drugs
Diseases
GWAS			Aortic root size ( 19584346) Birth weight ( 23202124) Brain structure ( 22504417) Head circumference (infant) ( 22504419) Height ( 21998595 20881960 22021425 19343178 23563607 18391950 18391951 18391952 20397748 17767157) Permanent tooth development ( 21931568) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Type 2 diabetes ( 20581827) Type 2 diabetes nephropathy ( 21150874)
Protein-Protein Interactions		14 interactors: ANP32A ATM ATR CDKN2A EHMT2 HMGA2 KRTAP10-4 KRTAP10-7 PRKDC RASSF1 RB1 SMAD9 TP53 UPF2	19 interactors: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP XRCC6
Entrez ID		1877	8091
HPRD ID		04317	02827
Ensembl ID		ENSG00000167967	ENSG00000149948
Uniprot IDs		Q66K89	F5H2A4 P52926
PDB IDs
Enriched GO Terms of Interacting Partners?		Replicative Senescence Cell Cycle Process Cell Aging Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Process Cell Cycle Positive Regulation Of Cell Aging Regulation Of Signal Transduction By P53 Class Mediator Cell Cycle Arrest DNA Damage Checkpoint Response To Gamma Radiation Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Nucleobase-containing Compound Metabolic Process Chromosome Organization Positive Regulation Of Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Peptidyl-serine Phosphorylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Aging Cellular Senescence Cellular Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Response To Ionizing Radiation Intracellular Signal Transduction Chromatin Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Senescence-associated Heterochromatin Focus Assembly Double-strand Break Repair Mitotic Cell Cycle Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Senescence	Negative Regulation Of Cellular Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Viral Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Negative Regulation Of Cell Cycle Transcription, DNA-templated Regulation Of RNA Metabolic Process Cell Cycle Process RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Cell Cycle Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Mitotic Cell Cycle Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Type I Interferon Production Regulation Of Cell Cycle Process Response To Stress
Tagcloud ?		adenoviral arrest autophagy contributing coprecipitation databases derivative directed downregulate downregulation e1a g1 hbv hbx hcc hepatitis hepatocellular hepatocyte hepg2 interference marked multifunctional neutralize oncoprotein possibly public vacuolation vesicles viability	accumulated approaches basic benign demonstrates encoding hook2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work
Tagcloud (Difference) ?		adenoviral arrest autophagy contributing coprecipitation databases derivative directed downregulate downregulation e1a g1 hbv hbx hcc hepatitis hepatocellular hepatocyte hepg2 interference marked multifunctional neutralize oncoprotein possibly public vacuolation vesicles viability	accumulated approaches basic benign demonstrates encoding hook2 initiating leiomyoma leiomyomas limits mesenchymal mobility myometrial opens origin possibilities putative rearrangements side sp stem toward transformation truncated understand uterine work
Tagcloud (Intersection) ?