E4F1 and HMGA2

Number of citations: 55 (PubMedID 14645522)
Data Source: BioGRID (far western blotting)

		E4F1	HMGA2
Name		E4F transcription factor 1	high mobility group AT-hook 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Nuclear Body	Nuclear Chromosome Chromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity CAMP Response Element Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding Nucleic Acid Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Cycle Process Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Cell Division Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of DNA-templated Transcription Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Virus Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Cell Proliferation In Forebrain Pituitary Gland Development Negative Regulation Of Wnt Signaling Pathway Chromosome Condensation Adrenal Gland Development Heterochromatin Formation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Multicellular Organism Growth Intracellular Signal Transduction Endodermal Cell Differentiation Chondrocyte Proliferation Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Host-mediated Suppression Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Mesodermal Cell Differentiation Astrocyte Differentiation Negative Regulation Of Astrocyte Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Regulation Of Growth Hormone Secretion Lung Epithelium Development Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Adipose Tissue Development Fat Pad Development Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Stem Cell Proliferation Regulation Of Peptide Hormone Secretion Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Cellular Senescence Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		None	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
GWAS		Appendicular lean mass ( 33097823 )	Adverse response to drug ( 30420678 ) Aortic root size ( 19584346 ) Appendicular lean mass ( 33097823 ) Axial length ( 24144296 ) Birth length ( 25281659 ) Birth weight ( 31043758 27680694 23202124 ) Body size at age 10 ( 32376654 ) Brain structure ( 22504417 ) Childhood body mass index ( 33045005 ) Chin dimples ( 27182965 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Cortical surface area (global PC1) ( 32198502 ) Cortical volume ( 32963231 ) Fasting insulin ( 34059833 ) Haemorrhoidal disease ( 33888516 ) Head circumference (infant) ( 22504419 ) Heart rate response to exercise ( 29769521 ) Heel bone mineral density ( 30598549 ) Height ( 25282103 18391952 28552196 20881960 18391951 18391950 25429064 19343178 21998595 20397748 23563607 22021425 31562340 17767157 ) Hip circumference ( 25673412 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Hip index ( 34021172 ) Infant length ( 25281659 ) Late-onset Alzheimer's disease ( 27770636 ) Medication use (drugs used in diabetes) ( 31015401 ) Neutrophil count ( 32888494 ) Offspring birth weight ( 31043758 ) Permanent tooth development ( 21931568 ) Plateletcrit ( 32888494 ) Polycystic ovary syndrome ( 22885925 ) Primary tooth development (number of teeth) ( 20195514 23704328 ) Primary tooth development (time to first tooth eruption) ( 23704328 20195514 ) Pulse pressure ( 27841878 ) Systolic blood pressure ( 27841878 31928498 ) Triglyceride levels ( 32203549 ) Type 2 diabetes ( 32499647 28869590 20581827 30297969 30054458 29358691 26961502 25102180 24509480 22885922 ) Type 2 diabetes nephropathy ( 21150874 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 25673412 ) Youthful appearance (self-reported) ( 32339537 )
Interacting Genes		16 interacting genes: ANP32A ATM ATR CDKN2A EHMT2 HMGA2 KRTAP10-4 KRTAP10-7 PARP1 PRKDC RASSF1 RB1 SMAD9 SMARCA4 TP53 UPF2	21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 KAT2B MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53
Entrez ID		1877	8091
HPRD ID		04317	02827
Ensembl ID		ENSG00000167967	ENSG00000149948
Uniprot IDs		H3BSL4 H3BUJ7 Q66K89	F5H2A4 F5H6H0 P52926 Q1M183
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Chromosome Organization Replicative Senescence Histone H2AXS139 Kinase Activity Response To Gamma Radiation Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Chromosome Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA Repair Regulation Of Chromosome Organization Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle P53 Binding Intracellular Signal Transduction Protein Localization To Organelle Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Ras Protein Signal Transduction Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Double-strand Break Repair Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Disordered Domain Specific Binding Telomere Maintenance	Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoplasm Negative Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Chromatin Organization Nucleus Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Chromatin Binding Positive Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Chromatin Remodeling Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Positive Regulation Of Transcription By RNA Polymerase II Response To Peptide Hormone DNA-binding Transcription Factor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Process DNA Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Response To Stress Regulation Of Cell Cycle RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Oxidative Stress