E4F1 and KRTAP10-4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		E4F1	KRTAP10-4
Description		E4F transcription factor 1	keratin associated protein 10-4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Nuclear Body	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Transferase Activity CAMP Response Element Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Transcription By RNA Polymerase II Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Cycle Process Protein Ubiquitination Positive Regulation Of Transcription By RNA Polymerase II Cell Division Regulation Of Cell Cycle
Pathways			Keratinization
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Leukocyte telomere length ( 32109421)
Interacting Genes		16 interacting genes: ANP32A ATM ATR CDKN2A EHMT2 HMGA2 KRTAP10-4 KRTAP10-7 PARP1 PRKDC RASSF1 RB1 SMAD9 SMARCA4 TP53 UPF2	11 interacting genes: CATSPER1 E4F1 HOXA1 IGSF8 JOSD1 OTX1 RSPO2 WT1 ZNF32 ZNF625 ZSCAN26
Entrez ID		1877	386672
HPRD ID		04317	11190
Ensembl ID		ENSG00000167967	ENSG00000215454
Uniprot IDs		H3BSL4 H3BUJ7 Q66K89	P60372
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromosome Organization Replicative Senescence Histone H2AXS139 Kinase Activity Response To Gamma Radiation Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Regulation Of Double-strand Break Repair Regulation Of Cell Cycle Process Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Protein Localization To Chromosome Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of DNA Repair Regulation Of Chromosome Organization Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Regulation Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphate Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Cellular Senescence Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle P53 Binding Intracellular Signal Transduction Protein Localization To Organelle Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Ras Protein Signal Transduction Negative Regulation Of Mitotic Cell Cycle Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Double-strand Break Repair Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Protein Localization To Site Of Double-strand Break DNA Damage Checkpoint Signaling Disordered Domain Specific Binding Telomere Maintenance	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Tube Morphogenesis Semicircular Canal Formation Sequence-specific Double-stranded DNA Binding Abducens Nerve Formation Optokinetic Behavior Diencephalon Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Regulation Of Animal Organ Morphogenesis Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Odontogenesis Of Dentin-containing Tooth Lung Growth Regulation Of RNA Metabolic Process Metencephalon Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Trachea Cartilage Morphogenesis Embryonic Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Branching Morphogenesis Of An Epithelial Tube Double-stranded Methylated DNA Binding S-shaped Body Morphogenesis Zinc Ion Binding Embryonic Neurocranium Morphogenesis Anterior/posterior Pattern Specification Diaphragm Development Regulation Of Female Gonad Development Morphogenesis Of A Branching Structure Positive Regulation Of Male Gonad Development Morphogenesis Of A Branching Epithelium Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Membrane Biogenesis CatSper Complex Outer Ear Morphogenesis
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