APLNR and MARK4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		APLNR	MARK4
Description		apelin receptor	microtubule affinity regulating kinase 4
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Cell Projection Neuron Projection
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Apelin Receptor Activity Mechanoreceptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Cytoskeletal Anchor Activity Kinase Activity Transferase Activity Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping G Protein-coupled Receptor Internalization Atrioventricular Valve Development Endocardial Cushion Formation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of G Protein-coupled Receptor Internalization	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Nervous System Development Cell Projection Organization Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Positive Regulation Of Cell Cycle Regulation Of Centrosome Cycle Microtubule Polymerization Cell Division Cilium Disassembly Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Centrosome
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Anchoring of the basal body to the plasma membrane
Drugs			Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Basophil count ( 32888494) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil count ( 32888494 27863252) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Granulocyte count ( 27863252) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) LDL cholesterol levels ( 32203549) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Triglyceride levels ( 32203549) White blood cell count ( 27863252 32888494)
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	32 interacting genes: AKT1 APLNR CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MED20 MTUS2 NEDD4 NLRP3 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ
Entrez ID		187	57787
HPRD ID		02503	09402
Ensembl ID		ENSG00000134817	ENSG00000007047
Uniprot IDs		B2RDH3 B3KQN4 P35414	Q96L34
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM 7SUS 7W0L 7W0M 7W0N 7W0O 7W0P 8XQE 8XQF 8XQI 8XQJ 8XZF 8XZG 8XZH 8XZI 8XZJ 8Z74 8Z7J	5ES1 8XFL
Enriched GO Terms of Interacting Partners?		Prostaglandin H2 Endoperoxidase Reductase Activity L-glucuronate Reductase Activity Glyceraldehyde Oxidoreductase Activity Fructose Biosynthetic Process Glycerol Dehydrogenase (NADP+) Activity Chaperone-mediated Autophagy Translocation Complex Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Apelin Receptor Signaling Pathway Apelin Receptor Binding Peptidyl-histidine Methylation Protein-L-histidine N-tele-methyltransferase Activity	Microtubule Cytoskeleton Protein Domain Specific Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Phosphoserine Residue Binding Microtubule Regulation Of Cellular Component Organization Cytosol Cytoskeleton Structural Molecule Activity Regulation Of Transport Golgi Localization Organelle Organization Cytoplasm Regulation Of Cellular Localization Tubulin Binding Regulation Of Cell Communication Regulation Of Signaling Cilium Intracellular Protein Localization GTP-dependent Protein Binding Cytoskeleton Organization Extracellular Exosome Regulation Of Neuron Projection Development Positive Regulation Of Transport Regulation Of Synapse Organization Negative Regulation Of Cell Projection Organization Positive Regulation Of Vesicle Transport Along Microtubule Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Supramolecular Fiber Organization Regulation Of Signal Transduction Regulation Of Protein Localization Regulation Of TORC1 Signaling Neuron Projection Main Axon Nuclear Receptor-mediated Corticosteroid Signaling Pathway Structural Constituent Of Cytoskeleton Protein Targeting PAR Polarity Complex Enzyme Binding Regulation Of Cell Growth Microtubule-based Process Establishment Of Golgi Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Microtubule Binding Regulation Of Cell Development Regulation Of Organelle Transport Along Microtubule Transmembrane Transporter Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Nervous System Development
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