APLNR and NDRG4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		APLNR	NDRG4
Name		apelin receptor	NDRG family member 4
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Cell Projection Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Apelin Receptor Activity Mechanoreceptor Activity	Molecular_function Protein Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping G Protein-coupled Receptor Internalization Atrioventricular Valve Development Endocardial Cushion Formation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of G Protein-coupled Receptor Internalization	Heart Looping Signal Transduction Visual Learning Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cell Differentiation Embryonic Heart Tube Development Vesicle Docking Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Cell Proliferation Cell Migration Involved In Heart Development Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Endocytic Recycling
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	None
GWAS		No GWAS studies recorded	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Electrocardiographic traits ( 20062063 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 ) QT interval ( 19305408 19305409 22726844 ) Schizophrenia ( 29483656 )
Novel Interactors		None recorded	5 novel interactors: ADCY9 ALDH6A1 CMTM3 DHX38 NOL3
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	37 interacting genes: AGTRAP APLNR ARFIP2 ARL6IP1 ATP5PF BCL2L13 CACFD1 CDR1 CIDEB CMTM5 COQ3 CPLX2 DERL3 DGAT2L6 ERGIC3 LEUTX LIME1 LRRC59 MAL2 MTIF3 PLP2 PRAF2 RABAC1 REEP6 RTN3 SCAMP1 SDR16C5 SFT2D2 SGK1 SIN3A SMPD2 SYNGR1 SYNGR3 SYP THAP4 TMEM208 YIF1A
Entrez ID		187	65009
HPRD ID		02503	14817
Ensembl ID		ENSG00000134817	ENSG00000103034
Uniprot IDs		B2RDH3 B3KQN4 P35414	A0A0S2Z5L7 A0A0S2Z5R7 B7Z9X4 Q9ULP0
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM 7SUS 7W0L 7W0M 7W0N 7W0O 7W0P 8XQE 8XQF 8XQI 8XQJ 8XZF 8XZG 8XZH 8XZI 8XZJ 8Z74 8Z7J	Not available
GO Terms Enriched among Interactors		Prostaglandin H2 Endoperoxidase Reductase Activity L-glucuronate Reductase Activity Glyceraldehyde Oxidoreductase Activity Fructose Biosynthetic Process Glycerol Dehydrogenase (NADP+) Activity Chaperone-mediated Autophagy Translocation Complex Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Apelin Receptor Signaling Pathway Apelin Receptor Binding Peptidyl-histidine Methylation Protein-L-histidine N-tele-methyltransferase Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Synaptic Vesicle Vesicle-mediated Transport Endoplasmic Reticulum Tubular Network Formation Cytoplasmic Vesicle Endoplasmic Reticulum Tubular Network Membrane Organization Synaptic Vesicle Membrane Regulation Of Synaptic Vesicle Priming Protein Binding Regulation Of Short-term Neuronal Synaptic Plasticity Endoplasmic Reticulum Organization Synaptic Vesicle Membrane Organization Endoplasmic Reticulum Membrane Organization