APLNR and AKR1B1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		APLNR	AKR1B1
Description		apelin receptor	aldo-keto reductase family 1 member B
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Space Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Apelin Receptor Activity Mechanoreceptor Activity	Retinal Dehydrogenase (NAD+) Activity Aldose Reductase (NADPH) Activity Protein Binding Electron Transfer Activity Oxidoreductase Activity Prostaglandin H2 Endoperoxidase Reductase Activity Glyceraldehyde Oxidoreductase Activity Allyl-alcohol Dehydrogenase Activity L-glucuronate Reductase Activity Glycerol Dehydrogenase (NADP+) Activity All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping G Protein-coupled Receptor Internalization Atrioventricular Valve Development Endocardial Cushion Formation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of G Protein-coupled Receptor Internalization	Retinoid Metabolic Process Epithelial Cell Maturation Renal Water Homeostasis Carbohydrate Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process C21-steroid Hormone Biosynthetic Process Regulation Of Urine Volume Retinol Metabolic Process Negative Regulation Of Apoptotic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Fructose Biosynthetic Process Cellular Hyperosmotic Salinity Response Metanephric Collecting Duct Development
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Pregnenolone biosynthesis Fructose biosynthesis Galactose catabolism
Drugs			Glutathione NADH Sulindac Inhibitor Idd 384 alpha-D-glucose 6-phosphate Alrestatin Fidarestat (S,R)-fidarestat Zenarestat Tolrestat N-Acetylalanine Sorbinil IDD552 Cacodylic acid Nicotinamide adenine dinucleotide phosphate Citric acid Ranirestat Pimagedine QR-333 Exisulind (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID Lidorestat {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid CP-744809 (R)-minalrestat 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE IDD594 {[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid Zopolrestat Gavorestat
Diseases
GWAS			Blood protein levels ( 30072576) White matter growth ( 29682794)
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	5 interacting genes: APLNR CDC42 EFCAB11 SHBG SMAD1
Entrez ID		187	231
HPRD ID		02503	00071
Ensembl ID		ENSG00000134817	ENSG00000085662
Uniprot IDs		B2RDH3 B3KQN4 P35414	P15121
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM 7SUS 7W0L 7W0M 7W0N 7W0O 7W0P 8XQE 8XQF 8XQI 8XQJ 8XZF 8XZG 8XZH 8XZI 8XZJ 8Z74 8Z7J	1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU 2AGT 2DUX 2DUZ 2DV0 2F2K 2FZ8 2FZ9 2FZB 2FZD 2HV5 2HVN 2HVO 2I16 2I17 2IKG 2IKH 2IKI 2IKJ 2INE 2INZ 2IPW 2IQ0 2IQD 2IS7 2ISF 2J8T 2NVC 2NVD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY 2PEV 2PF8 2PFH 2PZN 2QXW 2R24 3BCJ 3DN5 3G5E 3GHR 3GHS 3GHT 3GHU 3LBO 3LD5 3LEN 3LEP 3LQG 3LQL 3LZ3 3LZ5 3M0I 3M4H 3M64 3MB9 3MC5 3ONB 3ONC 3P2V 3Q65 3Q67 3RX2 3RX3 3RX4 3S3G 3T42 3U2C 3V35 3V36 4GCA 4GQ0 4IGS 4JIR 4LAU 4LAZ 4LB3 4LB4 4LBR 4LBS 4NKC 4PR4 4PRR 4PRT 4PUU 4PUW 4Q7B 4QBX 4QR6 4QX4 4QXI 4RPQ 4XZH 4XZI 4YS1 4YU1 5HA7 5OU0 5OUJ 5OUK 6F7R 6F81 6F82 6F84 6F8O 6SYW 6T27 6T3P 6T5G 6T7Q 6TD8 6TUC 6TUF 6TXP 6XUM 6Y03 6Y1P 8A4N 8AE9 8AQG 8AQP 8AUU 8B34 8B3N 8B3R 8B66 8BJL 8CNF 8CNP 8FH5 8FH6 8FH7 8FH8 8FH9 8OZ2 8P2R
Enriched GO Terms of Interacting Partners?		Prostaglandin H2 Endoperoxidase Reductase Activity L-glucuronate Reductase Activity Glyceraldehyde Oxidoreductase Activity Fructose Biosynthetic Process Glycerol Dehydrogenase (NADP+) Activity Chaperone-mediated Autophagy Translocation Complex Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Apelin Receptor Signaling Pathway Apelin Receptor Binding Peptidyl-histidine Methylation Protein-L-histidine N-tele-methyltransferase Activity	Cardiac Conduction System Development Negative Regulation Of CAMP-mediated Signaling Mechanoreceptor Activity Apelin Receptor Activity Apelin Receptor Signaling Pathway Cardiac Muscle Tissue Development GBD Domain Binding Storage Vacuole Modulation Of Process Of Another Organism Host-mediated Perturbation Of Symbiont Process Homomeric SMAD Protein Complex Positive Regulation Of G Protein-coupled Receptor Internalization Striated Muscle Tissue Development Endothelin Receptor Signaling Pathway Involved In Heart Process Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Positive Regulation Of Endocytosis Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Venous Blood Vessel Development Apolipoprotein A-I Receptor Binding Muscle Tissue Development Neuropilin Signaling Pathway Anti-Mullerian Hormone Receptor Signaling Pathway Androgen Binding Positive Regulation Of Epithelial Cell Proliferation Atrioventricular Valve Development Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Tube Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Acetylcholine Receptor Inhibitor Activity SMAD Protein Complex Vascular Associated Smooth Muscle Cell Differentiation Regulation Of Gap Junction Assembly Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Epithelium Development Neuron Fate Determination Establishment Of Golgi Localization Golgi Transport Complex Heteromeric SMAD Protein Complex Primary MiRNA Binding DEAD/H-box RNA Helicase Binding Endocardial Cushion Formation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Adult Heart Development
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