APLNR and APLN

Number of citations of the paper that reports this interaction (PubMedID 12603839)
0

Data Source:
HPRD (in vivo)

		APLNR	APLN
Description		apelin receptor	apelin
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Apelin Receptor Activity Mechanoreceptor Activity	Signaling Receptor Binding Hormone Activity Apelin Receptor Binding Identical Protein Binding
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping G Protein-coupled Receptor Internalization Atrioventricular Valve Development Endocardial Cushion Formation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of G Protein-coupled Receptor Internalization	Angiogenesis Regulation Of The Force Of Heart Contraction G Protein-coupled Receptor Internalization Negative Regulation Of Systemic Arterial Blood Pressure Immune Response Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Lactation Feeding Behavior Positive Regulation Of Cell Population Proliferation Positive Regulation Of Heart Rate Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Positive Regulation Of Heat Generation Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Drinking Behavior Negative Regulation Of Blood Pressure Positive Regulation Of Heart Contraction Negative Regulation Of Vasoconstriction Regulation Of Body Fluid Levels Positive Regulation Of Corticotropin Secretion Positive Regulation Of Corticotropin-releasing Hormone Secretion Apelin Receptor Signaling Pathway Coronary Vasculature Development Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Endothelial Cell Proliferation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	8 interacting genes: APLNR GET3 MDFI PLSCR4 PSMA3 RBPMS TRIM55 TRIM63
Entrez ID		187	8862
HPRD ID		02503	02246
Ensembl ID		ENSG00000134817	ENSG00000171388
Uniprot IDs		B2RDH3 B3KQN4 P35414	Q9ULZ1
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM 7SUS 7W0L 7W0M 7W0N 7W0O 7W0P 8XQE 8XQF 8XQI 8XQJ 8XZF 8XZG 8XZH 8XZI 8XZJ 8Z74 8Z7J	8XQE 8XQF 8XZG 8XZH 8XZJ
Enriched GO Terms of Interacting Partners?		Prostaglandin H2 Endoperoxidase Reductase Activity L-glucuronate Reductase Activity Glyceraldehyde Oxidoreductase Activity Fructose Biosynthetic Process Glycerol Dehydrogenase (NADP+) Activity Chaperone-mediated Autophagy Translocation Complex Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Apelin Receptor Signaling Pathway Apelin Receptor Binding Peptidyl-histidine Methylation Protein-L-histidine N-tele-methyltransferase Activity	Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Muscle Hypertrophy Mechanoreceptor Activity Apelin Receptor Activity Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Apelin Receptor Signaling Pathway Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation Of G Protein-coupled Receptor Internalization GET Complex Calcium Activated Phosphatidylserine Scrambling MRNA CDS Binding Calcium Activated Phosphatidylcholine Scrambling Calcium Activated Phospholipid Scrambling Venous Blood Vessel Development Skeletal Muscle Atrophy
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