APLNR and GJB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APLNR	GJB2
Description		apelin receptor	gap junction protein beta 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Signaling Receptor Activity Apelin Receptor Activity Mechanoreceptor Activity	Gap Junction Channel Activity Calcium Ion Binding Protein Binding Identical Protein Binding Metal Ion Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process	Angiogenesis Blood Vessel Development Vasculogenesis Vasculature Development Heart Looping G Protein-coupled Receptor Internalization Atrioventricular Valve Development Endocardial Cushion Formation Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gastrulation Heart Development Adult Heart Development Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Vascular Associated Smooth Muscle Cell Differentiation Aorta Development Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of Angiogenesis Regulation Of Body Fluid Levels Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Apelin Receptor Signaling Pathway Ventricular Septum Morphogenesis Venous Blood Vessel Development Coronary Vasculature Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Gap Junction Assembly Positive Regulation Of G Protein-coupled Receptor Internalization	Cell Communication Cell-cell Signaling Sensory Perception Of Sound Cell Communication By Electrical Coupling Gap Junction Assembly Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly Transport of connexons to the plasma membrane
Drugs
Diseases			Deafness, autosomal recessive Keratitis-ichthyosis-deafness syndrome Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis Deafness, autosomal dominant Palmoplantar keratoderma with deafness
GWAS			Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		8 interacting genes: AKR1B1 APLN GJB2 LAMP2 MARK4 MTCH1 NDRG4 SETD3	44 interacting genes: AMIGO1 APLNR AQP6 ARL13B CAV1 CD14 CNST CREB3 EBP ERGIC3 FAM209A FFAR2 GJA5 GJA8 GJB1 GJB6 GPR152 GPR42 HSD17B13 KCNK5 KLRC1 LHFPL5 LMNA LRRC4C MFSD6 MS4A6E PEX12 PLEKHB2 SAR1A SHISAL1 SLC10A6 SLC18A1 SLC30A2 SSMEM1 TBXA2R TEX29 TIMMDC1 TLCD4 TM2D2 TMEM106A TMEM237 TMEM31 TMX2 TRHR
Entrez ID		187	2706
HPRD ID		02503	00413
Ensembl ID		ENSG00000134817	ENSG00000165474
Uniprot IDs		B2RDH3 B3KQN4 P35414	H9U1J4 P29033
PDB IDs		2LOT 2LOU 2LOV 2LOW 5VBL 6KNM 7SUS 7W0L 7W0M 7W0N 7W0O 7W0P 8XQE 8XQF 8XQI 8XQJ 8XZF 8XZG 8XZH 8XZI 8XZJ 8Z74 8Z7J	2ZW3 3IZ1 3IZ2 5ER7 5ERA 5KJ3 5KJG 6UVR 6UVS 6UVT 7QEO 7QEQ 7QER 7QES 7QET 7QEU 7QEV 7QEW 7QEY 8Q9Z 8QA0 8QA1 8QA2 8QA3
Enriched GO Terms of Interacting Partners?		Prostaglandin H2 Endoperoxidase Reductase Activity L-glucuronate Reductase Activity Glyceraldehyde Oxidoreductase Activity Fructose Biosynthetic Process Glycerol Dehydrogenase (NADP+) Activity Chaperone-mediated Autophagy Translocation Complex Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Smooth Muscle Cell Proliferation Apelin Receptor Signaling Pathway Apelin Receptor Binding Peptidyl-histidine Methylation Protein-L-histidine N-tele-methyltransferase Activity	Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Gap Junction Assembly Protein Binding Plasma Membrane Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Vasoconstriction Connexin Binding Atrioventricular Valve Development Gap Junction-mediated Intercellular Transport Regulation Of Gap Junction Assembly Intercellular Transport G Protein-coupled Receptor Activity Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Muscle System Process Transmembrane Transport Regulation Of Vasoconstriction
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