DYRK1A and LZTS2

Number of citations of the paper that reports this interaction (PMID 23602568)
8

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer, affinity chromatography technology)

		DYRK1A	LZTS2
Gene Name		dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	leucine zipper, putative tumor suppressor 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex	Cytoplasm Centrosome Microtubule Midbody
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Positive Regulation Of Protein Deacetylation	Cytokinesis Kidney Development Mitotic Nuclear Division Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Microtubule Severing Nuclear Export Spindle Midzone Assembly Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus
Pathways		G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		26 interactors: AMPH APP CCNL2 CLASRP CREB1 FOXO1 GLI1 HIST1H2BB HIST1H3A HIST1H4A LATS2 LIN52 LZTS2 PHYHIP PRD RB1 RBL1 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	172 interactors: ABT1 AEN ANKRD11 ANKRD36BP1 AP1M1 ARHGAP32 ARMC7 ARNT2 ATPAF2 BAHD1 BEX2 BMS1P5 BYSL C14orf105 C19orf66 C1orf109 C20orf195 C6orf165 C8orf33 CARD9 CBX8 CCDC85B CCNC CCNG1 CCNK CDC23 CDK18 CDKL3 CEP57L1 CHCHD3 CLIP4 CNNM3 COPB1 CWF19L2 DCUN1D1 DGCR6 DGCR6L DYRK1A DYRK1B DYRK2 EHHADH EIF3D EIF4E2 FAM103A1 FAM107A FAM124B FAM161A FAM74A4 FANCL FBF1 FEM1C FGF12 FKBP6 FRG1 FRMD6 GCC1 GEM GFI1B GMCL1P1 GNL3L GPATCH2L GRB2 HLA-DPB1 HM13 HOMER2 HSPD1 IQCE KAT5 KAZN KIAA1683 KIF9 KIFC3 KPNA2 LASP1 LCK LIN37 LMO1 LMO2 MAB21L3 MAGEB4 MEMO1 MORF4L1 MORF4L2 MORN3 MOS MTA1 NCBP2 NCK2 NDE1 NEBL NEK6 NINL NIP7 OTUB2 PAK7 PITX1 PKP4 PLEKHN1 POLDIP3 POLR1C PPP1R18 PQBP1 PRKAB2 PSMA1 QARS RAC1 RAD51D RBFOX1 RBM15 RBM41 RBPMS RCOR3 RHNO1 RHOXF2 RIN1 RNF32 RNF41 RTP5 RUNX1T1 SCNM1 SH2D4A SH3RF2 SLC15A3 SLC25A6 SLU7 SMIM3 SNHG11 SNW1 SNX31 SPATA2 SPATA24 SPATC1L SPG7 SRSF2 STAC SUPV3L1 SUV39H1 TBC1D7 TCEA2 TCHP TEAD4 THAP10 THAP7 TNIP3 TRAF2 TRIM29 TRIM42 TSNAX TTC23 TXNL4A USF2 USP2 UTP14C WDYHV1 WT1-AS YTHDC1 ZBTB25 ZBTB38 ZGPAT ZKSCAN3 ZMAT1 ZMAT2 ZMYND19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF446 ZNF490 ZNF512B ZNF572 ZNF581
Entrez ID		1859	84445
HPRD ID		09018	14341
Ensembl ID		ENSG00000157540	ENSG00000107816
Uniprot IDs		F8WAP0 Q13627	Q9BRK4
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE
Enriched GO Terms of Interacting Partners?		Gene Expression Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA 3'-end Processing Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Phosphorylation Cellular Nitrogen Compound Metabolic Process MRNA Processing Negative Regulation Of Gene Expression RNA 3'-end Processing RNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear Export Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation MRNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process RNA Splicing Response To Growth Factor Positive Regulation Of Mitochondrion Organization Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Apoptotic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway	RNA Metabolic Process Gene Expression Transcription, DNA-templated Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Ribonucleoprotein Complex Biogenesis Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Viral Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Positive Regulation Of Cellular Metabolic Process Organelle Organization RNA Processing Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus RNA Splicing MRNA Processing Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter MRNA Splicing, Via Spliceosome MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of T Cell Activation Cellular Process Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild	a549 anticancer chemotherapeutic clones credits effectively exposing gltscr2 lats1 making mdr1 nf1 paclitaxel panel predetermined profiling pten regards screen screened shrna shrnas smad4 st14 suppressors tumorigenesis tumorigenic vhl wt1
Tagcloud (Difference) ?		abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting wild	a549 anticancer chemotherapeutic clones credits effectively exposing gltscr2 lats1 making mdr1 nf1 paclitaxel panel predetermined profiling pten regards screen screened shrna shrnas smad4 st14 suppressors tumorigenic vhl wt1
Tagcloud (Intersection) ?		tumorigenesis