AGT and ECE1

Number of citations of the paper that reports this interaction (PMID 18039931)
23

Data Source:
BioGRID (enzymatic study)

		AGT	ECE1
Gene Name		angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	endothelin converting enzyme 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Ovarian Follicle Rupture Regulation Of Cell Growth Blood Vessel Development Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Angiotensin Mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Renal Response To Blood Flow Involved In Circulatory Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Regulation Of Blood Vessel Size By Renin-angiotensin Renal System Process Angiotensin-mediated Drinking Behavior Positive Regulation Of Extracellular Matrix Constituent Secretion Cellular Sodium Ion Homeostasis Cell-matrix Adhesion G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Activation Of NF-kappaB-inducing Kinase Activity Nitric Oxide Mediated Signal Transduction Cell-cell Signaling Female Pregnancy Aging Excretion Establishment Of Blood-nerve Barrier Negative Regulation Of Cell Proliferation Response To Cold Response To Salt Stress Positive Regulation Of Activation Of JAK2 Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Negative Regulation Of Endopeptidase Activity Regulation Of Norepinephrine Secretion Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Artery Smooth Muscle Contraction Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Negative Regulation Of Angiogenesis Regulation Of Vasoconstriction Extracellular Matrix Organization Negative Regulation Of Cell Growth Peristalsis Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of Tissue Remodeling Low-density Lipoprotein Particle Remodeling Catenin Import Into Nucleus Regulation Of Renal Sodium Excretion Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Multicellular Organism Growth Regulation Of Cell Proliferation Vasodilation Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Metabolic Process Cellular Protein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasodilation Positive Regulation Of Organ Growth Astrocyte Activation Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of Long-term Neuronal Synaptic Plasticity Smooth Muscle Cell Proliferation Cytokine Secretion Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Smooth Muscle Cell Differentiation Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Regulation Of Calcium Ion Transport Regulation Of Transmission Of Nerve Impulse Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Protein Tyrosine Kinase Activity ERK1 And ERK2 Cascade Uterine Smooth Muscle Contraction Cellular Response To Mechanical Stimulus Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Kinase C Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Peptide hormone metabolism GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Metabolism of Angiotensinogen to Angiotensins G alpha (i) signalling events Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		22 interactors: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB ITSN2 KNG1 MAS1 MEP1A MME PRCP PREP PRG2 REN TP53	8 interactors: AGT CALCA CLK2 EDN1 KNG1 KRTAP10-1 KRTAP10-5 MYOC
Entrez ID		183	1889
HPRD ID		00106	02690
Ensembl ID		ENSG00000135744	ENSG00000117298
Uniprot IDs		B0ZBE2 B2R5S1 P01019	B4DKB2 P42892
PDB IDs		1N9U 1N9V 2JP8 2WXW 2X0B 4AA1 4APH 4FYS	3DWB
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Angiotensin Metabolic Process Regulation Of Systemic Arterial Blood Pressure Angiotensin Maturation Regulation Of Blood Pressure Peptide Hormone Processing Blood Circulation Peptide Metabolic Process Cellular Amide Metabolic Process Regulation Of Hormone Levels Hormone Metabolic Process Protein Processing Regulation Of Blood Volume By Renin-angiotensin Proteolysis Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin-activated Signaling Pathway Regulation Of Protein Metabolic Process Peptide Catabolic Process Regulation Of Renal Sodium Excretion Regulation Of Excretion Renal System Process Angiotensin Catabolic Process In Blood Regulation Of Metabolic Process Multicellular Organismal Protein Catabolic Process Kidney Development Multicellular Organismal Protein Metabolic Process Regulation Of Blood Vessel Size By Renin-angiotensin Renal System Development Regulation Of Vasodilation Urogenital System Development Regulation Of Vasoconstriction Drinking Behavior Brain Renin-angiotensin System Regulation Of Blood Vessel Size Regulation Of Tube Size System Development Positive Regulation Of Renal Sodium Excretion Organ Development Blood Coagulation, Intrinsic Pathway Regulation Of Inflammatory Response Negative Regulation Of Systemic Arterial Blood Pressure Replicative Senescence Regulation Of Signaling Extracellular Negative Regulation Of Signal Transduction Beta-amyloid Metabolic Process Digestion Protein Metabolic Process	Regulation Of Ion Homeostasis Regulation Of Blood Vessel Size Regulation Of Tube Size Positive Regulation Of Renal Sodium Excretion Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Muscle System Process Regulation Of Neurological System Process Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Blood Circulation Artery Smooth Muscle Contraction Cellular Metal Ion Homeostasis Regulation Of Systemic Arterial Blood Pressure Renal System Process Tonic Smooth Muscle Contraction Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Vascular Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Urine Volume Negative Regulation Of Tissue Remodeling Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Neurological System Process Involved In Regulation Of Systemic Arterial Blood Pressure Cellular Homeostasis Muscle Contraction Muscle Hypertrophy Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cell Differentiation Chemical Homeostasis Positive Regulation Of Vasodilation Vasoconstriction Negative Regulation Of Cellular Metabolic Process Cellular Calcium Ion Homeostasis Positive Regulation Of Oxidoreductase Activity Calcium Ion Homeostasis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Secretion Aging Positive Regulation Of Cell Migration Regulation Of Vasodilation Positive Regulation Of Cell Motility
Tagcloud ?		agc alleles amplified autophosphorylation berardinelli changing coding codon exons heterozygous iinsulin inheritance insulin lesion lipodystrophic lipodystrophy mellitus outside pathogenetic polymorphism polymorphisms recessive seip sequenced ser339 silent substitution unlikely val	5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype
Tagcloud (Difference) ?		agc alleles amplified autophosphorylation berardinelli changing coding codon exons heterozygous iinsulin inheritance insulin lesion lipodystrophic lipodystrophy mellitus outside pathogenetic polymorphism polymorphisms recessive seip sequenced ser339 silent substitution unlikely val	5xfad aggravated aggravates astrocytosis cleared confirms converting crossing degrades degrading develops endothelin genetics hallmarks hemi hemizygous homozygous imbalance knock metalloprotease mutual nep neprilysin neuropathological plaque reason reciprocal wildtype
Tagcloud (Intersection) ?