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AGT and REN
Number of citations of the paper that reports this interaction (PubMedID
12045255
)
40
Data Source:
BioGRID
(enzymatic study, x-ray crystallography, enzymatic study)
AGT
REN
Description
angiotensinogen
renin
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Plasma Membrane
Membrane
Apical Part Of Cell
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Hormone Activity
Protein Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Sodium Channel Regulator Activity
Type 1 Angiotensin Receptor Binding
Type 2 Angiotensin Receptor Binding
Receptor Ligand Activity
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Signaling Receptor Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Peptidase Activity
Hydrolase Activity
Biological Process
Regulation Of Cell Growth
Positive Regulation Of Cytokine Production
Kidney Development
Blood Vessel Remodeling
Regulation Of Blood Volume By Renin-angiotensin
Renin-angiotensin Regulation Of Aldosterone Production
Regulation Of Renal Output By Angiotensin
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Renal System Process
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Regulation Of Blood Pressure
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Response To Muscle Activity Involved In Regulation Of Muscle Adaptation
Regulation Of Vasoconstriction
Positive Regulation Of Superoxide Anion Generation
Low-density Lipoprotein Particle Remodeling
Regulation Of Renal Sodium Excretion
Nitric Oxide-cGMP-mediated Signaling
Angiotensin-activated Signaling Pathway
Regulation Of Cell Population Proliferation
Vasoconstriction
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Inflammatory Response
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Renal Sodium Ion Absorption
Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Positive Regulation Of Cholesterol Metabolic Process
Blood Vessel Diameter Maintenance
Positive Regulation Of Angiotensin-activated Signaling Pathway
Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Extracellular Matrix Assembly
Negative Regulation Of Sodium Ion Transmembrane Transport
Positive Regulation Of Membrane Hyperpolarization
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Gap Junction Assembly
Regulation Of Cardiac Conduction
Response To Angiotensin
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Kidney Development
Mesonephros Development
Angiotensin Maturation
Regulation Of Blood Volume By Renin-angiotensin
Renin-angiotensin Regulation Of Aldosterone Production
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Proteolysis
Regulation Of Blood Pressure
Male Gonad Development
Response To Xenobiotic Stimulus
Hormone-mediated Signaling Pathway
Gene Expression
Response To Lipopolysaccharide
Response To Immobilization Stress
Angiotensin-activated Signaling Pathway
Drinking Behavior
Regulation Of MAPK Cascade
Cell Maturation
Amyloid-beta Metabolic Process
Response To CAMP
Response To CGMP
Cellular Response To Xenobiotic Stimulus
Juxtaglomerular Apparatus Development
Pathways
PPARA activates gene expression
Metabolism of Angiotensinogen to Angiotensins
Metabolism of Angiotensinogen to Angiotensins
Peptide ligand-binding receptors
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
Metabolism of Angiotensinogen to Angiotensins
Drugs
Zinc
Copper
Sparsentan
Zinc acetate
Remikiren
Minoxidil
Lisinopril
N,N-dimethylformamide
Isoamyl alcohol
3-Phenyl-1,2-Propandiol
2-Methyl-3-(2-Aminothiazolo)Propanal
Enalkiren
2-Cyclopropylmethylenepropanal
1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine
N-Methyl-N-(Methylbenzyl)Formamide
1-Hydroxy-2-Amino-3-Cyclohexylpropane
SPP1148
N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE
6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE
N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE
(2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE
6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE
5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
6-ethyl-5-[(2S)-1-(3-methoxypropyl)-2-phenyl-1,2,3,4-tetrahydroquinolin-7-yl]pyrimidine-2,4-diamine
Aliskiren
Diseases
Renal tubular dysgenesis
Uromodulin-associated kidney diseases, including: Medullary cystic kidney disease 2; Familial juvenile hyperuremic nephropathy; Glomerulocystic kidney disease
Renal tubular dysgenesis
GWAS
Blood protein levels (
30072576
)
Coronary artery disease (
33020668
29212778
)
Diastolic blood pressure (
27618452
28739976
27841878
)
Diastolic blood pressure (cigarette smoking interaction) (
29455858
)
Diastolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Mean arterial pressure (
27618448
)
Medication use (agents acting on the renin-angiotensin system) (
31015401
)
Pancreatic ductal adenocarcinoma (
30541042
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Systolic blood pressure (
27841878
27618452
30578418
)
Systolic blood pressure (cigarette smoking interaction) (
29455858
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Blood protein levels in cardiovascular risk (
28369058
)
Response to cognitive-behavioural therapy in anxiety disorder (
31123309
)
Interacting Genes
24 interacting genes:
ACE2
AGTR1
AGTR2
ATP6AP2
CMA1
CTSG
DNPEP
ECE1
ENPEP
EWSR1
GRB2
GSDMB
HSP90AA1
ITSN2
KNG1
LNPEP
MAS1
MEP1A
MME
PRCP
PREP
PRG2
REN
TP53
9 interacting genes:
AGT
ATP6AP2
CCDC24
CTSB
KCTD15
M6PR
PCSK1
PCSK5
RENBP
Entrez ID
183
5972
HPRD ID
00106
01564
Ensembl ID
ENSG00000135744
ENSG00000143839
Uniprot IDs
A0A7P0T8D1
B0ZBE2
B2R5S1
P01019
P00797
PDB IDs
1N9U
1N9V
2JP8
2WXW
2X0B
3CK0
3WOO
3WOR
4AA1
4APH
4FYS
5E2Q
5M3X
5M3Y
5XJM
6I3F
6I3I
6JOD
6OS0
7C6A
1BBS
1BIL
1BIM
1HRN
1RNE
2BKS
2BKT
2FS4
2G1N
2G1O
2G1R
2G1S
2G1Y
2G20
2G21
2G22
2G24
2G26
2G27
2I4Q
2IKO
2IKU
2IL2
2REN
2V0Z
2V10
2V11
2V12
2V13
2V16
2X0B
3D91
3G6Z
3G70
3G72
3GW5
3K1W
3KM4
3O9L
3OAD
3OAG
3OOT
3OQF
3OQK
3OWN
3Q3T
3Q4B
3Q5H
3SFC
3VCM
3VSW
3VSX
3VUC
3VYD
3VYE
3VYF
4AMT
4GJ5
4GJ6
4GJ7
4GJ8
4GJ9
4GJA
4GJB
4GJC
4GJD
4PYV
4Q1N
4RYC
4RYG
4RZ1
4S1G
4XX3
4XX4
5KOQ
5KOS
5KOT
5SXN
5SY2
5SY3
5SZ9
5T4S
5TMG
5TMK
5V8V
5VPM
5VRP
6I3F
7XGK
7XGO
7XGP
Enriched GO Terms of Interacting Partners
?
Angiotensin Maturation
Peptide Hormone Processing
Signaling Receptor Ligand Precursor Processing
Protein Processing
Hormone Metabolic Process
Protein Maturation
Peptidase Activity
Regulation Of Blood Pressure
Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal
Regulation Of Hormone Levels
Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin
Regulation Of Biological Quality
Regulation Of Systemic Arterial Blood Pressure
Peptide Metabolic Process
Metallopeptidase Activity
Proteolysis
Blood Vessel Diameter Maintenance
Regulation Of Tube Size
Peptide Catabolic Process
Angiotensin Type II Receptor Activity
Angiotensin-activated Signaling Pathway
Neuropeptide Catabolic Process
Hydrolase Activity
Metallocarboxypeptidase Activity
Vascular Process In Circulatory System
Plasma Membrane
Endopeptidase Activity
Circulatory System Process
Extracellular Exosome
Regulation Of Multicellular Organismal Process
Regulation Of Reactive Oxygen Species Metabolic Process
Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure
Oligopeptidase Activity
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Systemic Arterial Blood Pressure
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Renin-angiotensin Regulation Of Aldosterone Production
Substance P Catabolic Process
Protein Metabolic Process
Peptide Binding
Aminopeptidase Activity
System Process
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Regulation Of Blood Circulation
Regulation Of Blood Volume By Renin-angiotensin
Negative Regulation Of Blood Pressure
Bradykinin Catabolic Process
Extracellular Region
Vasodilation
Positive Regulation Of Cardiac Muscle Contraction
Peptide Hormone Processing
Signaling Receptor Ligand Precursor Processing
Hormone Metabolic Process
Regulation Of Hormone Levels
Endopeptidase Activity
Peptide Biosynthetic Process
Protein Processing
Proteolysis
Plasma Lipoprotein Particle Remodeling
Protein-containing Complex Remodeling
Peptide Metabolic Process
Protein Maturation
N-acylglucosamine 2-epimerase Activity
Eye Pigmentation
Regulation Of Biological Quality
Positive Regulation Of Membrane Hyperpolarization
G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger
Type 2 Angiotensin Receptor Binding
N-acetylmannosamine Metabolic Process
Central Nervous System Maturation
Transport Vesicle
Positive Regulation Of Angiotensin-activated Signaling Pathway
Renin-angiotensin Regulation Of Aldosterone Production
Response To Muscle Activity Involved In Regulation Of Muscle Adaptation
Regulation Of Renal Output By Angiotensin
Peptidase Activity
Rostrocaudal Neural Tube Patterning
Lysosome
Protein Secretion
Establishment Of Protein Localization To Extracellular Region
Protein Localization To Extracellular Region
Serine-type Peptidase Activity
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Peptidase Inhibitor Complex
Viral Life Cycle
Renin Secretion Into Blood Stream
Regulation Of Membrane Hyperpolarization
Type 1 Angiotensin Receptor Binding
Regulation Of Angiotensin-activated Signaling Pathway
Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin
Endolysosome Lumen
Secretion Of Lysosomal Enzymes
Cytokine Precursor Processing
Serine-type Endopeptidase Activity
Cell-cell Signaling
Regulation Of Blood Volume By Renin-angiotensin
Positive Regulation Of Gap Junction Assembly
Anterior/posterior Pattern Specification
N-acetylneuraminate Catabolic Process
Positive Regulation Of Transforming Growth Factor Beta1 Production
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