AGT and AGTR1

Number of citations of the paper that reports this interaction (PubMedID 15930094)
0

Data Source:
HPRD (in vivo)

		AGT	AGTR1
Description		angiotensinogen	angiotensin II receptor type 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Blood Microparticle	Plasma Membrane Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Sodium Channel Regulator Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding Receptor Ligand Activity	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Renal System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Vasoconstriction Positive Regulation Of Superoxide Anion Generation Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Vasoconstriction Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Inflammatory Response Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Renal Sodium Ion Absorption Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Extracellular Matrix Assembly Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Membrane Hyperpolarization Positive Regulation Of MiRNA Transcription Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Response To Angiotensin Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Vasoconstriction Calcium-mediated Signaling Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Symbiont Entry Into Host Cell Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Zinc Copper Sparsentan Zinc acetate	Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Angiotensin II Candesartan
Diseases		Renal tubular dysgenesis	Renal tubular dysgenesis
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 33020668 29212778) Diastolic blood pressure ( 27618452 28739976 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pancreatic ductal adenocarcinoma ( 30541042) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		24 interacting genes: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB HSP90AA1 ITSN2 KNG1 LNPEP MAS1 MEP1A MME PRCP PREP PRG2 REN TP53	77 interacting genes: ABI3 ACE2 ADD3 AGT AGTRAP AP2M1 ARFGAP1 ARHGDIG ARRB1 ARRB2 ATP13A1 ATP1B1 BAALC BASP1 BDKRB2 BNIP3 BRD8 CBR1 CCDC25 CD37 CERS6 CUEDC2 DBNDD2 DNAJC14 DNAJC8 EGFR FAM13B FBXW11 FNBP1 GHITM GNA12 GOT1 GPAA1 GPRASP1 GRK2 GRK3 GRK5 HDGFL2 HHATL HRAS JAK1 JAK2 JKAMP KIAA0930 LCNL1 LLGL1 LZTS1 NACAD NDRG2 NOS3 NPTN NUP88 OAZ1 PCMT1 PDE6H PLCG1 PLCH2 PNMA1 PPP1R3F PSMD10 PTGFR RAB5A RAF1 RBSN RTN3 SAE1 SCG5 SELENOF SERINC3 SLC16A1 SPG21 THOP1 TMEM161A TMEM80 UBR4 UGT8 YWHAQ
Entrez ID		183	185
HPRD ID		00106	00107
Ensembl ID		ENSG00000135744	ENSG00000144891
Uniprot IDs		A0A7P0T8D1 B0ZBE2 B2R5S1 P01019	A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5
PDB IDs		1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS 5E2Q 5M3X 5M3Y 5XJM 6I3F 6I3I 6JOD 6OS0 7C6A	4YAY 4ZUD 6DO1 6OS0 6OS1 6OS2
Enriched GO Terms of Interacting Partners?		Angiotensin Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Protein Maturation Peptidase Activity Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Biological Quality Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Metallopeptidase Activity Proteolysis Blood Vessel Diameter Maintenance Regulation Of Tube Size Peptide Catabolic Process Angiotensin Type II Receptor Activity Angiotensin-activated Signaling Pathway Neuropeptide Catabolic Process Hydrolase Activity Metallocarboxypeptidase Activity Vascular Process In Circulatory System Plasma Membrane Endopeptidase Activity Circulatory System Process Extracellular Exosome Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Oligopeptidase Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Substance P Catabolic Process Protein Metabolic Process Peptide Binding Aminopeptidase Activity System Process Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Circulation Regulation Of Blood Volume By Renin-angiotensin Negative Regulation Of Blood Pressure Bradykinin Catabolic Process Extracellular Region Vasodilation Positive Regulation Of Cardiac Muscle Contraction	Negative Adaptation Of Signaling Pathway Desensitization Of G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor Internalization Type 1 Angiotensin Receptor Binding G Protein-coupled Receptor Binding G Protein-coupled Receptor Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Receptor-mediated Endocytosis Regulation Of Cell Communication Regulation Of Signaling Angiotensin Receptor Binding Endocytic Vesicle Membrane Membrane Type II Interferon-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Biological Quality Regulation Of Muscle System Process Regulation Of Protein Modification Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Circulation Postsynaptic Density Negative Regulation Of Signal Transduction Establishment Of Protein Localization Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Endocytosis Regulation Of MAPK Cascade Regulation Of Vasoconstriction Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Receptor Internalization Regulation Of The Force Of Heart Contraction By Chemical Signal Positive Regulation Of Gap Junction Assembly Interferon-mediated Signaling Pathway Plasma Membrane Clathrin-coated Pit Protein Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Phosphorylation Cytoplasm ERBB Signaling Pathway Import Into Cell Negative Regulation Of Apoptotic Process Tachykinin Receptor Signaling Pathway
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