DNASE2 and XRN1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		DNASE2	XRN1
Description		deoxyribonuclease 2, lysosomal	5'-3' exoribonuclease 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Extracellular Exosome	P-body Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body
	Molecular Function	DNA Binding Nuclease Activity Endonuclease Activity DNA Endonuclease Activity Deoxyribonuclease II Activity Protein Binding Hydrolase Activity	G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity G-quadruplex DNA Binding Telomerase RNA Binding
	Biological Process	DNA Metabolic Process DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Enucleate Erythrocyte Differentiation Regulation Of Immune Response	Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide Cellular Response To Puromycin
Pathways		Lysosome Vesicle Biogenesis	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Immature fraction of reticulocytes ( 27863252) Mean corpuscular volume ( 29403010) Red cell distribution width ( 28957414)	Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)
Interacting Genes		1 interacting genes: XRN1	67 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MIR34C MIR429 MIR7-1 MTCH2 MTREX NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF10 RNF187 SDHB SKIC2 SLC61A1 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36
Entrez ID		1777	54464
HPRD ID		00531	10470
Ensembl ID		ENSG00000105612	ENSG00000114127
Uniprot IDs		O00115	Q8IZH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Puromycin Cellular Response To Cycloheximide DNA-methyltransferase Activity Germ Cell Nucleus DNA (cytosine-5-)-methyltransferase Activity Regulation Of Phenotypic Switching Cellular Response To Bisphenol A Response To Cycloheximide 5'-3' RNA Exonuclease Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A G-quadruplex RNA Binding G-quadruplex DNA Binding 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Female Germ Cell Nucleus Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Histone MRNA Catabolic Process RRNA Catabolic Process Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Apoptotic Process Negative Regulation Of Smooth Muscle Cell Differentiation Cellular Response To Oxygen-containing Compound Telomerase RNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Histone MRNA Metabolic Process Replication Fork LncRNA Binding Methyl-CpG Binding Pericentric Heterochromatin Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Epigenetic Programming Of Gene Expression Regulation Of Smooth Muscle Cell Apoptotic Process DNA Methylation-dependent Constitutive Heterochromatin Formation Negative Regulation Of Gene Expression Nuclear RNA Surveillance Negative Regulation Of Telomere Maintenance RNA Surveillance Response To Testosterone Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Telomere Maintenance Via Telomerase Regulation Of Smooth Muscle Cell Differentiation Exonuclease Activity RNA Metabolic Process Negative Regulation Of Muscle Cell Apoptotic Process Heterochromatin	Nucleobase-containing Compound Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process Exosome (RNase Complex) Catabolic Process Nuclear Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nuclear RNA Surveillance RNA Surveillance ATP Biosynthetic Process RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoside Triphosphate Biosynthetic Process ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Proton Motive Force-driven ATP Synthesis MRNA 3'-UTR Binding Purine Ribonucleotide Biosynthetic Process RNA Binding Positive Regulation Of RNA Splicing Generation Of Precursor Metabolites And Energy Ribose Phosphate Biosynthetic Process Supraspliceosomal Complex SnRNA Metabolic Process Purine Nucleotide Biosynthetic Process MRNA Binding Exon-exon Junction Complex Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Proton Motive Force-driven Mitochondrial ATP Synthesis Energy Derivation By Oxidation Of Organic Compounds RNA Processing Purine Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process MRNA Transport SnRNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of MRNA Processing RRNA Processing Ribose Phosphate Metabolic Process
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