ACAN and IDH2

Data Source: HiPPIP (Novel)

		ACAN	IDH2
Name		aggrecan	isocitrate dehydrogenase (NADP(+)) 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP+ Metabolic Process NADP+ Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle
Drugs		Ilomastat	Isocitric Acid Enasidenib
Diseases		Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis Spondyloepiphyseal dysplasia, Kimberley type	None
GWAS		Age-related hearing impairment ( 27764096 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body size at age 10 ( 32376654 ) Dupuytren's disease ( 28886342 ) Height ( 20881960 31562340 28552196 33713608 18391952 28270201 25429064 25282103 25133637 23563607 21998595 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Infant length ( 25281659 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )	Cerebrospinal fluid clusterin levels ( 26545630 ) Gout ( 33832965 ) Pulse pressure ( 27841878 30578418 ) Urate levels ( 31578528 )
Interacting Genes		18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR	5 interacting genes: CDK1 FBXO7 PLK1 PYGL SLC2A4
Entrez ID		176	3418
HPRD ID		01123	00973
Ensembl ID		ENSG00000157766	ENSG00000182054
Uniprot IDs		A0A5K1VW97 P16112	B4DSZ6 P48735
PDB IDs		4MD4 7RDV	4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6UJ7 6UJ8 6UJ9 6VFZ
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Peptidase Activity Hydrolase Activity Extracellular Region Extracellular Space Serine-type Endopeptidase Activity Proteolysis Cellular Response To UV-A Ovulation From Ovarian Follicle Ovulation Cycle Process Response To UV-A Ovulation Protein Metabolic Process Fibronectin Binding Zinc Ion Binding Endodermal Cell Differentiation Regulation Of Cell Migration Ovarian Follicle Development Regulation Of Cell Motility Metal Ion Binding Macromolecule Metabolic Process Regulation Of Locomotion Cellular Response To Radiation Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Cellular Response To UV Rhythmic Process Cellular Response To Light Stimulus Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Projection Regeneration Regulation Of Axon Regeneration Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Neuron Projection Regeneration Extracellular Matrix Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Trans-Golgi Network Transport Vesicle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Cycle Phase Transition Chromosome Condensation Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Negative Regulation Of Apoptotic Process Cellular Response To Chemical Stress Spindle Microtubule Nuclear Membrane Organization Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Mitotic DNA Integrity Checkpoint Signaling Striated Muscle Cell Development Centrosome Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Programmed Cell Death G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Golgi Lumen Mitotic DNA-templated DNA Replication Muscle Cell Development