IDH2

Description		isocitrate dehydrogenase (NADP(+)) 2
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Metal Ion Binding NAD Binding
	Biological Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP+ Metabolic Process NADP+ Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion
Pathways		Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle) Mitochondrial protein degradation Maturation of TCA enzymes and regulation of TCA cycle
Drugs		Isocitric Acid Enasidenib
Diseases
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Gout ( 33832965) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)
Novel Interacting Genes		3 novel interacting genes: ACAN FURIN GPX1
Interacting Genes		5 interacting genes: CDK1 FBXO7 PLK1 PYGL SLC2A4
Entrez ID		3418
HPRD ID		00973
Ensembl ID		ENSG00000182054
Uniprot IDs		B4DSZ6 P48735
PDB IDs		4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI 6UJ7 6UJ8 6UJ9 6VFZ
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Membrane Disassembly Membrane Disassembly Nuclear Membrane Disassembly Trans-Golgi Network Transport Vesicle Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Protein Localization To Site Of Double-strand Break Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Cycle Phase Transition Chromosome Condensation Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle G2/M Phase Transition Pronuclear Fusion Negative Regulation Of Apoptotic Process Cellular Response To Chemical Stress Spindle Microtubule Nuclear Membrane Organization Negative Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Mitotic DNA Integrity Checkpoint Signaling Striated Muscle Cell Development Centrosome Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Programmed Cell Death G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Amylopectin Biosynthetic Process D-glucose Uniporter Activity Regulation Of Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Regulation Of Protein Catabolic Process Regulation Of Proteolysis Macromolecule Metabolic Process Golgi Lumen Mitotic DNA-templated DNA Replication Muscle Cell Development
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