ACAN and TNFAIP6

Number of citations of the paper that reports this interaction (PMID 9654129)
10

Data Source:
HPRD (in vitro)

		ACAN	TNFAIP6
Gene Name		aggrecan	tumor necrosis factor, alpha-induced protein 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Metal Ion Binding	Hyaluronic Acid Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Proteolysis Cell Adhesion Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Inflammatory Response Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Migration Ovulation
Pathways
Drugs
Diseases
GWAS		Height ( 21998595 20881960 23563607 18391952)	Lung cancer ( 23143601)
Protein-Protein Interactions		18 interactors: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR VCAN	3 interactors: ACAN THBS1 UBC
Entrez ID		176	7130
HPRD ID		01123	02680
Ensembl ID		ENSG00000157766	ENSG00000123610
Uniprot IDs		E7ENV9 E7EX88	P98066
PDB IDs			1O7B 1O7C 2PF5 2WNO
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Ovulation Skeletal System Development Multicellular Organismal Development Endodermal Cell Differentiation Endoderm Formation Developmental Process Single Organism Reproductive Process Reproductive Process Anatomical Structure Development Ovulation From Ovarian Follicle Endoderm Development System Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Protein Oligomerization Protein Metabolic Process Organ Development Formation Of Primary Germ Layer Regulation Of Protein Oligomerization Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cardiovascular System Development Response To Stress Gastrulation Reproductive Structure Development Reproductive System Development Trabecula Morphogenesis Female Pregnancy Gonad Development Development Of Primary Sexual Characteristics Reproduction Negative Regulation Of Axon Extension Involved In Regeneration Anatomical Structure Formation Involved In Morphogenesis Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Response To Stimulus Glial Cell Migration Ossification	Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Carbohydrate Metabolic Process Activation Of MAPK Activity Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Regulation Of Cellular Response To Growth Factor Stimulus Cartilage Development Pathogenesis Negative Regulation Of Cytokine Production Positive Regulation Of MAP Kinase Activity Connective Tissue Development Engulfment Of Apoptotic Cell Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Activation Of Protein Kinase Activity Skeletal System Morphogenesis Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Response To Hypoxia Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Antigen Processing And Presentation Regulation Of CGMP-mediated Signaling Positive Regulation Of Cytokine Production Extracellular Matrix Organization Extracellular Structure Organization Glycoprotein Biosynthetic Process Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Plasminogen Activation Positive Regulation Of Transforming Growth Factor Beta1 Production Glycoprotein Metabolic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Negative Regulation Of Fibrinolysis Positive Regulation Of Kinase Activity Positive Regulation Of Fibroblast Migration Positive Regulation Of Endothelial Cell Apoptotic Process Protein O-linked Fucosylation Keratan Sulfate Catabolic Process Viral Protein Processing Positive Regulation Of Macrophage Activation Regulation Of Cytokine Production Cellular Response To Nitric Oxide Chronic Inflammatory Response Phagocytosis, Engulfment Regulation Of Fibrinolysis Skeletal System Development Positive Regulation Of Transferase Activity
Tagcloud ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	antiapoptosis aspp2 bax card caspases caspy clearly inducible kinetic lr mc mcl messenger microcystin necrosis ppm1d proapoptosis pycard pyd siva superfamily taip2 tnfsf10 tp53inp1 traf2bp transforming utilized zebrafish
Tagcloud (Difference) ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	antiapoptosis aspp2 bax card caspases caspy clearly inducible kinetic lr mc mcl messenger microcystin necrosis ppm1d proapoptosis pycard pyd siva superfamily taip2 tnfsf10 tp53inp1 traf2bp transforming utilized zebrafish
Tagcloud (Intersection) ?