ACAN and TNFAIP6

Number of citations: 0 (PubMedID 9654129)
Data Source: HPRD (in vitro)

		ACAN	TNFAIP6
Name		aggrecan	TNF alpha induced protein 6
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net	Extracellular Region Extracellular Space Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Fibronectin Binding Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Hydrolase Activity Metal Ion Binding Carboxylesterase Activity
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development	Ovarian Cumulus Expansion Inflammatory Response Cell Adhesion Signal Transduction Cell-cell Signaling Hyaluronan Metabolic Process Positive Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Inflammatory Response Negative Regulation Of Neutrophil Chemotaxis Positive Regulation Of Receptor Clustering Fibronectin Fibril Organization
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	Neutrophil degranulation
Drugs		Ilomastat	Donepezil Acetylsalicylic acid Hyaluronic acid
Diseases		Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis Spondyloepiphyseal dysplasia, Kimberley type	None
GWAS		Age-related hearing impairment ( 27764096 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body size at age 10 ( 32376654 ) Dupuytren's disease ( 28886342 ) Height ( 20881960 31562340 28552196 33713608 18391952 28270201 25429064 25282103 25133637 23563607 21998595 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Infant length ( 25281659 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )	Blood protein levels ( 30072576 ) Lung cancer ( 23143601 )
Novel Interactors		5 novel interactors: BLM IDH2 MAN2A2 SLCO3A1 STARD5	None recorded
Interacting Genes		18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR	3 interacting genes: ACAN THBS1 UBC
Entrez ID		176	7130
HPRD ID		01123	02680
Ensembl ID		ENSG00000157766	ENSG00000123610
Uniprot IDs		A0A5K1VW97 P16112	P98066
PDB IDs		4MD4 7RDV	1O7B 1O7C 2N40 2PF5 2WNO
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Peptidase Activity Hydrolase Activity Extracellular Region Extracellular Space Serine-type Endopeptidase Activity Proteolysis Cellular Response To UV-A Ovulation From Ovarian Follicle Ovulation Cycle Process Response To UV-A Ovulation Protein Metabolic Process Fibronectin Binding Zinc Ion Binding Endodermal Cell Differentiation Regulation Of Cell Migration Ovarian Follicle Development Regulation Of Cell Motility Metal Ion Binding Macromolecule Metabolic Process Regulation Of Locomotion Cellular Response To Radiation Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Cellular Response To UV Rhythmic Process Cellular Response To Light Stimulus Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Projection Regeneration Regulation Of Axon Regeneration Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Neuron Projection Regeneration Extracellular Matrix Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Perineuronal Net Extracellular Space Extracellular Matrix Structural Constituent Negative Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Negative Regulation Of Nitric Oxide Mediated Signal Transduction Nitric Oxide-cGMP-mediated Signaling Chronic Inflammatory Response Negative Regulation Of Antigen Processing And Presentation Negative Regulation Of Fatty Acid Transport Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Collagen V Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Transforming Growth Factor Beta1 Production Blood Coagulation, Fibrin Clot Formation Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Regulation Of CGMP-mediated Signaling Regulation Of Long-chain Fatty Acid Import Into Cell Fibrinogen Binding Fibrinogen Complex Proteoglycan Binding Engulfment Of Apoptotic Cell Negative Regulation Of CGMP-mediated Signaling Regulation Of Nitric Oxide Mediated Signal Transduction Hyaluronic Acid Binding Regulation Of Antigen Processing And Presentation Low-density Lipoprotein Particle Binding Fibroblast Growth Factor Binding Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Fibrinolysis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Binding Protein Activation Cascade Behavioral Response To Pain Negative Regulation Of Focal Adhesion Assembly Response To Magnesium Ion Positive Regulation Of Endothelial Cell Apoptotic Process Platelet Alpha Granule Laminin Binding Negative Regulation Of Sprouting Angiogenesis Nitric Oxide Mediated Signal Transduction Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Interleukin-12 Production Positive Regulation Of Fibroblast Migration Regulation Of Plasminogen Activation