ACAN and MMP8

Number of citations of the paper that reports this interaction (PMID 8216228)
30

Data Source:
HPRD (in vitro)

		ACAN	MMP8
Gene Name		aggrecan	matrix metallopeptidase 8 (neutrophil collagenase)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Golgi Lumen Extracellular Matrix Lysosomal Lumen	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Carbohydrate Binding Metal Ion Binding	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Zinc Ion Binding
	Biological Process	Skeletal System Development Carbohydrate Metabolic Process Proteolysis Cell Adhesion Pathogenesis Keratan Sulfate Biosynthetic Process Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Endodermal Cell Differentiation
Pathways			Collagen degradation Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs			Marimastat 1-Hydroxyamine-2-Isobutylmalonic Acid 2-Thiomethyl-3-Phenylpropanoic Acid 2-(Biphenyl-4-Sulfonyl)-1,2,3,4-Tetrahydro-Isoquinoline-3-Carboxylic Acid 2-Hydroxy-5-[4-(2-Hydroxy-Ethyl)-Piperidin-1-Yl]-5-Phenyl-1h-Pyrimidine-4,6-Dione Glycinamid Batimastat N-{2-[(4\'-CYANO-1,1\'-BIPHENYL-4-YL)OXY]ETHYL}-N\'-HYDROXY-N-METHYLUREA (5S)-5-(2-amino-2-oxoethyl)-4-oxo-N-[(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl)methyl]-3,4,5,6,7,8-hexahydro[1]benzothieno[2,3-d]pyrimidine-2-carboxamide (1S)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID (1R)-1-{[(4\'-METHOXY-1,1\'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID 3-FORMYL-2-HYDROXY-5-METHYL-HEXANOIC ACID HYDROXYAMIDE BUT-3-ENYL-[5-(4-CHLORO-PHENYL)-3,6-DIHYDRO-[1,3,4]THIADIAZIN-2-YLIDENE]-AMINE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID 3-AMINO-AZACYCLOTRIDECAN-2-ONE
Diseases
GWAS		Height ( 21998595 20881960 23563607 18391952)	Prostate cancer ( 23535732)
Protein-Protein Interactions		18 interactors: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 TNFAIP6 TNR VCAN	7 interactors: ACAN BCAN CCL2 TFPI TIMP2 UBC UMOD
Entrez ID		176	4317
HPRD ID		01123	00385
Ensembl ID		ENSG00000157766	ENSG00000118113
Uniprot IDs		E7ENV9 E7EX88	P22894
PDB IDs			1A85 1A86 1BZS 1I73 1I76 1JAN 1JAO 1JAP 1JAQ 1JH1 1JJ9 1KBC 1MMB 1MNC 1ZP5 1ZS0 1ZVX 2OY2 2OY4 3DNG 3DPE 3DPF 3TT4
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Catabolic Process Ovulation Skeletal System Development Multicellular Organismal Development Endodermal Cell Differentiation Endoderm Formation Developmental Process Single Organism Reproductive Process Reproductive Process Anatomical Structure Development Ovulation From Ovarian Follicle Endoderm Development System Development Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Positive Regulation Of Protein Oligomerization Protein Metabolic Process Organ Development Formation Of Primary Germ Layer Regulation Of Protein Oligomerization Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Cardiovascular System Development Response To Stress Gastrulation Reproductive Structure Development Reproductive System Development Trabecula Morphogenesis Female Pregnancy Gonad Development Development Of Primary Sexual Characteristics Reproduction Negative Regulation Of Axon Extension Involved In Regeneration Anatomical Structure Formation Involved In Morphogenesis Glycosaminoglycan Catabolic Process Cellular Response To Amino Acid Stimulus Response To Stimulus Glial Cell Migration Ossification	Extracellular Matrix Disassembly Pathogenesis Neutrophil Migration Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Response To Vitamin B3 Helper T Cell Extravasation Negative Regulation Of Natural Killer Cell Chemotaxis Cellular Response To High Density Lipoprotein Particle Stimulus Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Metanephric Thick Ascending Limb Development Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Negative Regulation Of Lymphocyte Chemotaxis Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway Response To Cytokine Response To High Density Lipoprotein Particle Negative Regulation Of Catalytic Activity Glycosaminoglycan Metabolic Process Metanephric Ascending Thin Limb Development Negative Regulation Of Lymphocyte Migration Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Viral Life Cycle Regulation Of Cellular Protein Metabolic Process Response To Transforming Growth Factor Beta Response To Fibroblast Growth Factor Blood Coagulation, Extrinsic Pathway Positive Regulation Of Phosphorylation Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Extravasation Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Mitotic Cell Cycle Leukocyte Migration MAPK Cascade Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Central Nervous System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Macrophage Chemotaxis Astrocyte Cell Migration Negative Regulation Of Leukocyte Chemotaxis Positive Regulation Of Apoptotic Cell Clearance
Tagcloud ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Difference) ?		acoustic bioreactor biot bm butanol chitosan chondrocyte col1a1 col2a1 connected cs csb impacted kpa mathematical mhz paralleled polycarbonate polyurethane porosities propagation scaffold scaffolds seeded served simplified sox supplied us	appreciated broader cascades classically cleavages cleaving conclusive curated dimension elastase inactivating operational perplexing pervasively polymorphonuclear posttranslational protease proteases proteome reachability representation scattered serpina1 spans subnetworks systematically unraveling viewed web
Tagcloud (Intersection) ?