ACAN and SLCO3A1

Data Source: HiPPIP (Novel)

		ACAN	SLCO3A1
Name		aggrecan	solute carrier organic anion transporter family member 3A1
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Synapse Perineuronal Net	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Carbohydrate Binding Metal Ion Binding	Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity
	Biological Process	Skeletal System Development Proteolysis Cell Adhesion Central Nervous System Development	Monoatomic Ion Transport Prostaglandin Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Sodium-independent Organic Anion Transport Positive Regulation Of MAPK Cascade Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Keratan sulfate biosynthesis Keratan sulfate degradation ECM proteoglycans Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	None
Drugs		Ilomastat	None
Diseases		Familial osteochondritis dissecans; Osteochondritis dissecans, short stature, and early-onset osteoarthritis Spondyloepiphyseal dysplasia, Kimberley type	None
GWAS		Age-related hearing impairment ( 27764096 ) Appendicular lean mass ( 33097823 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body size at age 10 ( 32376654 ) Dupuytren's disease ( 28886342 ) Height ( 20881960 31562340 28552196 33713608 18391952 28270201 25429064 25282103 25133637 23563607 21998595 ) Hip circumference adjusted for BMI ( 34021172 25673412 ) Infant length ( 25281659 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 )	Acute lymphoblastic leukemia (childhood) ( 22076464 ) Adult body size ( 32376654 ) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341 ) Diastolic blood pressure ( 30224653 ) DNA methylation (variation) ( 23725790 ) Estimated glomerular filtration rate reduction (30%) ( 30955190 ) Gastroesophageal reflux disease ( 27485664 ) Inattentive symptoms ( 18821565 ) Neuritic plaque ( 25188341 ) Obesity-related traits ( 23251661 ) Orofacial cleft x maternal periconceptional alcohol use interaction (1df) ( 33937227 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Primary sclerosing cholangitis ( 27992413 ) Refractive error ( 32231278 ) Response to iloperidone treatment (QT prolongation) ( 18521091 ) Smoking initiation ( 24665060 )
Novel Interactors		5 novel interactors: BLM IDH2 MAN2A2 SLCO3A1 STARD5	1 novel interactors: ACAN
Interacting Genes		18 interacting genes: ADAMTS1 ADAMTS4 ADAMTS5 CTSB FBLN1 FBLN2 HAPLN1 LUM MMP1 MMP14 MMP19 MMP2 MMP20 MMP3 MMP8 PTPRF TNFAIP6 TNR	7 interacting genes: AQP6 ARLN GOLM1 NHERF1 NHERF2 NHERF4 TRARG1
Entrez ID		176	28232
HPRD ID		01123	07502
Ensembl ID		ENSG00000157766	ENSG00000176463
Uniprot IDs		A0A5K1VW97 P16112	Q9UIG8
PDB IDs		4MD4 7RDV	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Metalloendopeptidase Activity Collagen Catabolic Process Metallopeptidase Activity Collagen Metabolic Process Endopeptidase Activity Peptidase Activity Hydrolase Activity Extracellular Region Extracellular Space Serine-type Endopeptidase Activity Proteolysis Cellular Response To UV-A Ovulation From Ovarian Follicle Ovulation Cycle Process Response To UV-A Ovulation Protein Metabolic Process Fibronectin Binding Zinc Ion Binding Endodermal Cell Differentiation Regulation Of Cell Migration Ovarian Follicle Development Regulation Of Cell Motility Metal Ion Binding Macromolecule Metabolic Process Regulation Of Locomotion Cellular Response To Radiation Perineuronal Net Extracellular Matrix Structural Constituent Conferring Compression Resistance Cellular Response To UV Rhythmic Process Cellular Response To Light Stimulus Hyaluronic Acid Binding Extracellular Matrix Structural Constituent Catabolic Process Anatomical Structure Formation Involved In Morphogenesis Neuron Projection Regeneration Regulation Of Axon Regeneration Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Adhesion Regulation Of Neuron Projection Regeneration Extracellular Matrix Binding Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion	Type 3 Metabotropic Glutamate Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Protein Localization To Plasma Membrane Protein Localization To Cell Periphery Protein Localization To Membrane Water Transport Localization Within Membrane Fluid Transport Endomembrane System Phosphatase Binding Nitrate Transmembrane Transporter Activity Renal Phosphate Ion Absorption Guanylate Cyclase Inhibitor Activity Apical Plasma Membrane Signaling Receptor Binding Apical Part Of Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Beta-catenin Binding Renal System Process Carbon Dioxide Transmembrane Transporter Activity Cytoplasmic Vesicle Membrane Carbon Dioxide Transmembrane Transport Cellular Localization Molecular Adaptor Activity Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding Negative Regulation Of CGMP-mediated Signaling Glucose Import In Response To Insulin Stimulus Monoatomic Anion Channel Activity Renal Water Transport Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Ammonium Channel Activity Intracellular Phosphate Ion Homeostasis Extracellular Matrix Structural Constituent Conferring Compression Resistance Perineuronal Net Ammonium Transmembrane Transport Water Channel Activity