IDH2 and SLC2A4

Number of citations of the paper that reports this interaction (PMID 16396496)
24

Data Source:
HPRD (in vivo)

		IDH2	SLC2A4
Gene Name		isocitrate dehydrogenase 2 (NADP+), mitochondrial	solute carrier family 2 (facilitated glucose transporter), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Extracellular Vesicular Exosome	Multivesicular Body Cytosol Plasma Membrane Integral Component Of Plasma Membrane Coated Pit External Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Clathrin-coated Vesicle Trans-Golgi Network Transport Vesicle T-tubule Insulin-responsive Compartment Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity NAD Binding	Glucose Transmembrane Transporter Activity Protein Binding D-glucose Transmembrane Transporter Activity
	Biological Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process	Carbohydrate Metabolic Process Hexose Transport Pathogenesis Amylopectin Biosynthetic Process Glucose Transport Cellular Response To Insulin Stimulus Glucose Homeostasis Small Molecule Metabolic Process Response To Ethanol Glucose Import Brown Fat Cell Differentiation Transmembrane Transport Membrane Organization Cellular Response To Hypoxia Cellular Response To Osmotic Stress
Pathways		Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Citric acid cycle (TCA cycle)	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds Translocation of GLUT4 to the plasma membrane SLC-mediated transmembrane transport Hexose transport Myoclonic epilepsy of Lafora Transcriptional regulation of white adipocyte differentiation Facilitative Na+-independent glucose transporters Glycogen storage diseases Glucose transport Metabolism of carbohydrates
Drugs
Diseases
GWAS			Birth weight ( 23202124) Metabolite levels ( 22286219)
Protein-Protein Interactions		2 interactors: PYGL SLC2A4	38 interactors: ACOX1 ACTN1 ACTN4 AKT2 ARF3 ARFIP1 BSG C1QTNF5 CCDC116 CFL1 CTSD DAXX DLD EHD2 ESYT2 FAR1 FKBP10 GAPDH HADH HK2 HSP90AA1 IDH2 KLHL41 LNPEP MAP1S MVP P3H1 P3H4 PDIA6 PRKAR1A PSMD7 RAB7A SERPINH1 SRFBP1 STRN3 UBA52 UBE2I UBE2N
Entrez ID		3418	6517
HPRD ID		00973	00688
Ensembl ID		ENSG00000182054	ENSG00000181856
Uniprot IDs		B4DFL2 B4DSZ6 P48735	P14672 Q05BQ3
PDB IDs		4JA8
Enriched GO Terms of Interacting Partners?		Glucose Homeostasis Pathogenesis Amylopectin Biosynthetic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Glucose Import Chemical Homeostasis Glycogen Catabolic Process Polysaccharide Catabolic Process Carbohydrate Metabolic Process Hexose Transmembrane Transport Cellular Response To Osmotic Stress Cellular Carbohydrate Catabolic Process Necroptotic Process Homeostatic Process Brown Fat Cell Differentiation Programmed Necrotic Cell Death Necrotic Cell Death Carbohydrate Transmembrane Transport Glycogen Metabolic Process Glucose Transport Hexose Transport Polysaccharide Metabolic Process Response To Osmotic Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Small Molecule Metabolic Process Carbohydrate Transport Fat Cell Differentiation Energy Reserve Metabolic Process Response To Ethanol Glucose Metabolic Process Carbohydrate Catabolic Process Ribose Phosphate Biosynthetic Process Hexose Metabolic Process Cellular Response To Insulin Stimulus Cellular Carbohydrate Metabolic Process Monosaccharide Metabolic Process Response To Insulin Response To Hypoxia Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Ribose Phosphate Metabolic Process Cellular Response To Peptide	Generation Of Precursor Metabolites And Energy Catabolic Process Protein Localization To Tight Junction Protein Transport Establishment Of Protein Localization Protein Localization Small Molecule Metabolic Process Organelle Organization Positive Regulation Of Transferase Activity Monocarboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Antigen Processing And Presentation Of Peptide Antigen Protein Targeting Blood Coagulation Hemostasis Pyruvate Metabolic Process Intracellular Protein Transport Oxidation-reduction Process Response To Stress Protein Localization To Cell Junction Glucose Metabolic Process Antigen Processing And Presentation Regulation Of Cellular Protein Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Establishment Of Localization In Cell Protein Polyubiquitination Response To Stimulus Cellular Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Cytoskeleton Organization Protein Localization To Membrane Platelet Degranulation Immune System Process Vesicle-mediated Transport Protein Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Extracellular Matrix Organization Extracellular Structure Organization Collagen Metabolic Process Membrane Organization Actin Cytoskeleton Organization Positive Regulation Of Ligase Activity Intracellular Receptor Signaling Pathway Transport Wound Healing Multicellular Organismal Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Protein Ubiquitination
Tagcloud ?		abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Difference) ?		abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating incurable optimize overview profoundly renders sf3b1 sibling spite stratify tet2 transplant video wider	atp1a2 atp1b2 beef corpus cows diestrus follicle glandular gonadotropin lcl lf luteum manipulated nelore ovulation p4 periovulatory pof preovulatory proestrus receptivity slaughtered slc5a1 washings
Tagcloud (Intersection) ?